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Volumn 112, Issue 25, 2005, Pages 3855-3867

Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: A meta-analysis of the randomized trials

Author keywords

Heparin; Meta analysis; Myocardial infarction; Thrombolysis

Indexed keywords

ACETYLSALICYLIC ACID; ANISTREPLASE; DALTEPARIN; ENOXAPARIN; FIBRINOLYTIC AGENT; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; REVIPARIN; STREPTOKINASE; TENECTEPLASE; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

EID: 33644877317     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.573550     Document Type: Article
Times cited : (116)

References (70)
  • 1
    • 0027125530 scopus 로고
    • The pathogenesis of coronary artery disease and the acute coronary syndromes (1)
    • Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med. 1992;326:242-250.
    • (1992) N Engl J Med , vol.326 , pp. 242-250
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3    Chesebro, J.H.4
  • 2
    • 0026541706 scopus 로고
    • The pathogenesis of coronary artery disease and the acute coronary syndromes (2)
    • Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med. 1992;326:310-318.
    • (1992) N Engl J Med , vol.326 , pp. 310-318
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3    Chesebro, J.H.4
  • 3
    • 0034600424 scopus 로고    scopus 로고
    • Unfractionated heparin and low-molecular-weight heparin in unstable angina without ST elevation: A meta-analysis
    • Eikelboom JW, Anand S, Malmberg K, Weitz J, Ginsberg J, Yusuf S. Unfractionated heparin and low-molecular-weight heparin in unstable angina without ST elevation: a meta-analysis. Lancet. 2000;355:1936-1942.
    • (2000) Lancet , vol.355 , pp. 1936-1942
    • Eikelboom, J.W.1    Anand, S.2    Malmberg, K.3    Weitz, J.4    Ginsberg, J.5    Yusuf, S.6
  • 4
    • 0036788546 scopus 로고    scopus 로고
    • ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: Summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina)
    • Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, Hochman JS, Jones RH, Kereiakes D, Kupersmith J, Levin TN, Pepine CJ, Schaeffer JW, Smith EE III, Steward DE, Theroux P. ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina). Circulation. 2002;106:1893-1900.
    • (2002) Circulation , vol.106 , pp. 1893-1900
    • Braunwald, E.1    Antman, E.M.2    Beasley, J.W.3    Califf, R.M.4    Cheitlin, M.D.5    Hochman, J.S.6    Jones, R.H.7    Kereiakes, D.8    Kupersmith, J.9    Levin, T.N.10    Pepine, C.J.11    Schaeffer, J.W.12    Smith III, E.E.13    Steward, D.E.14    Theroux, P.15
  • 6
    • 3843091541 scopus 로고    scopus 로고
    • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: Executive summary: A report of the ACC/AHA Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines on the Management of Patients with Acute Myocardial Infarction)
    • Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, Hochman JS, Krumholz HM, Kushner FG, Lamas GA, Mullany CJ, Ornato JP, Pearle DL, Sloan MA, Smith SC Jr. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: executive summary: a report of the ACC/AHA Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines on the Management of Patients With Acute Myocardial Infarction). Circulation. 2004;110:588-636.
    • (2004) Circulation , vol.110 , pp. 588-636
    • Antman, E.M.1    Anbe, D.T.2    Armstrong, P.W.3    Bates, E.R.4    Green, L.A.5    Hand, M.6    Hochman, J.S.7    Krumholz, H.M.8    Kushner, F.G.9    Lamas, G.A.10    Mullany, C.J.11    Ornato, J.P.12    Pearle, D.L.13    Sloan, M.A.14    Smith Jr., S.C.15
  • 8
    • 0029916513 scopus 로고    scopus 로고
    • Overview of randomized trials of intravenous heparin in patients with acute myocardial infraction treated with thrombolytic therapy
    • Mahaffey KW, Granger CB, Collins R, O'Connor CM, Ohman M, Bleich SD, Col JJ, Califf RM. Overview of randomized trials of intravenous heparin in patients with acute myocardial infraction treated with thrombolytic therapy. Am J Cardiol. 1996;77:551-556.
    • (1996) Am J Cardiol , vol.77 , pp. 551-556
    • Mahaffey, K.W.1    Granger, C.B.2    Collins, R.3    O'Connor, C.M.4    Ohman, M.5    Bleich, S.D.6    Col, J.J.7    Califf, R.M.8
  • 9
    • 0030893793 scopus 로고    scopus 로고
    • Aspirin, heparin, and fibrinolytic therapy in suspected acute myocardial infarction
    • Collins R, Peto R, Baigent C, Sleight P. Aspirin, heparin, and fibrinolytic therapy in suspected acute myocardial infarction. N Engl J Med. 1997;336:847-860.
    • (1997) N Engl J Med , vol.336 , pp. 847-860
    • Collins, R.1    Peto, R.2    Baigent, C.3    Sleight, P.4
  • 10
    • 0036710892 scopus 로고    scopus 로고
    • The role of low-molecular-weight heparin in cardiovascular diseases
    • Mukherjee D, Topol EJ. The role of low-molecular-weight heparin in cardiovascular diseases. Prog Cardiovasc Dis. 2002;45:139-156.
    • (2002) Prog Cardiovasc Dis , vol.45 , pp. 139-156
    • Mukherjee, D.1    Topol, E.J.2
  • 11
    • 12544249141 scopus 로고    scopus 로고
    • Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation
    • Yusuf S, Mehta SR, Xie C, Ahmed RJ, Xavier D, Pais P, Zhu J, Liu L, for the CREATE Trial Group Investigators. Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation. JAMA. 2005;293:427-435.
    • (2005) JAMA , vol.293 , pp. 427-435
    • Yusuf, S.1    Mehta, S.R.2    Xie, C.3    Ahmed, R.J.4    Xavier, D.5    Pais, P.6    Zhu, J.7    Liu, L.8
  • 12
    • 0344837325 scopus 로고    scopus 로고
    • Meta-analysis of randomized trials comparing enoxaparin versus unfractionated heparin as adjunctive therapy to fibrinolysis in ST-elevation acute myocardial infarction
    • Theroux P, Welsh RC. Meta-analysis of randomized trials comparing enoxaparin versus unfractionated heparin as adjunctive therapy to fibrinolysis in ST-elevation acute myocardial infarction. Am J Cardiol. 2003;91:860-864.
    • (2003) Am J Cardiol , vol.91 , pp. 860-864
    • Theroux, P.1    Welsh, R.C.2
  • 13
    • 0037438875 scopus 로고    scopus 로고
    • Use of low-molecular-weight heparins in the management of acute coronary artery syndromes and percutaneous coronary intervention
    • Wong GC, Giugliano RP, Antman EM. Use of low-molecular-weight heparins in the management of acute coronary artery syndromes and percutaneous coronary intervention. JAMA. 2003;289:331-342.
    • (2003) JAMA , vol.289 , pp. 331-342
    • Wong, G.C.1    Giugliano, R.P.2    Antman, E.M.3
  • 14
    • 85047692188 scopus 로고
    • Empirical evidence of bias: Dimensions of methodological quality with estimates of treatment effects in controlled trials
    • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality with estimates of treatment effects in controlled trials. JAMA. 1995;273:408-412.
    • (1995) JAMA , vol.273 , pp. 408-412
    • Schulz, K.F.1    Chalmers, I.2    Hayes, R.J.3    Altman, D.G.4
  • 15
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of diseases
    • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of diseases. J Natl Cancer Inst. 1959;22:719-748.
    • (1959) J Natl Cancer Inst , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 16
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Scheider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Scheider, M.3    Minder, C.4
  • 18
    • 0025335032 scopus 로고
    • GISSI-2: A factorial randomized trial of alteplase versus streptokinase and heparin versus no heparin among 12490 patients with acute myocardial infarction
    • Gruppo Italiano Per Lo Studio Della Sopravvivenz Nell'Infarto Miocardico. GISSI-2: a factorial randomized trial of alteplase versus streptokinase and heparin versus no heparin among 12490 patients with acute myocardial infarction. Lancet. 1990;336:65-71.
    • (1990) Lancet , vol.336 , pp. 65-71
  • 19
    • 0025092298 scopus 로고
    • A comparison between heparin and low-dose aspirin as adjunctive therapy with tissue plasminogen activator for acute myocardial infarction
    • Hsia J, Hamilton WP, Kleiman N, Roberts R, Chaitman BR, Ross AM, for the Heparin-Aspirin Reperfusion Trial (HART) Investigators. A comparison between heparin and low-dose aspirin as adjunctive therapy with tissue plasminogen activator for acute myocardial infarction. N Engl J Med. 1990;323:1433-1437.
    • (1990) N Engl J Med , vol.323 , pp. 1433-1437
    • Hsia, J.1    Hamilton, W.P.2    Kleiman, N.3    Roberts, R.4    Chaitman, B.R.5    Ross, A.M.6
  • 20
    • 0026607185 scopus 로고
    • ISIS-3: A randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41299 cases of suspected acute myocardial infarction
    • Third International Study of Infarct Survival Collaborative Group. ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41299 cases of suspected acute myocardial infarction. Lancet. 1992;339:753-770.
    • (1992) Lancet , vol.339 , pp. 753-770
  • 21
    • 0029164835 scopus 로고
    • Thrombolysis with recombinant unglycosylated single-chain urokinase-type plasminogen activator (saruplase) in acute myocardial infarction: Influence of heparin on early patency rate (LIMITS study)
    • Tebbe U, Windeler J, Boesl I, Hoffmann H, Wojcik J, Ashmawy M, Schwarz ER, Von Loewis P, Rosemeyer P, Hopkins G, Barth H. Thrombolysis with recombinant unglycosylated single-chain urokinase-type plasminogen activator (saruplase) in acute myocardial infarction: influence of heparin on early patency rate (LIMITS study). J Am Coll Cardiol. 1995;26:365-373.
    • (1995) J Am Coll Cardiol , vol.26 , pp. 365-373
    • Tebbe, U.1    Windeler, J.2    Boesl, I.3    Hoffmann, H.4    Wojcik, J.5    Ashmawy, M.6    Schwarz, E.R.7    Von Loewis, P.8    Rosemeyer, P.9    Hopkins, G.10    Barth, H.11
  • 22
    • 0029993943 scopus 로고    scopus 로고
    • Reduction of reinfarction and angina with use of low-molecular-weight heparin therapy after streptokinase (and heparin) in acute myocardial infarction
    • Glick A, Kornowski R, Michowich Y, Koifman B, Roth A, Laniado S, Keren G. Reduction of reinfarction and angina with use of low-molecular-weight heparin therapy after streptokinase (and heparin) in acute myocardial infarction. Am J Cardiol. 1996;77:1145-1148.
    • (1996) Am J Cardiol , vol.77 , pp. 1145-1148
    • Glick, A.1    Kornowski, R.2    Michowich, Y.3    Koifman, B.4    Roth, A.5    Laniado, S.6    Keren, G.7
  • 23
    • 0029801296 scopus 로고    scopus 로고
    • A comparison of aspirin and anticoagulation following thrombolysis for myocardial infarction (the AFTER study): A multicentre unblinded randomised clinical trial
    • Julian DG, Chamberlain DA, Pocock SJ. A comparison of aspirin and anticoagulation following thrombolysis for myocardial infarction (the AFTER study): a multicentre unblinded randomised clinical trial. BMJ. 1996;313:1429-1431.
    • (1996) BMJ , vol.313 , pp. 1429-1431
    • Julian, D.G.1    Chamberlain, D.A.2    Pocock, S.J.3
  • 25
    • 0031042683 scopus 로고    scopus 로고
    • Systemic thrombin generation and activity resistant to low molecular weight heparin administered prior to streptokinase in patients with acute myocardial infarction
    • Nilsen DWT, Goransson L, Larsen AI, Hetland O, Kierulf P. Systemic thrombin generation and activity resistant to low molecular weight heparin administered prior to streptokinase in patients with acute myocardial infarction. Thromb Haemost. 1997;77:57-61.
    • (1997) Thromb Haemost , vol.77 , pp. 57-61
    • Nilsen, D.W.T.1    Goransson, L.2    Larsen, A.I.3    Hetland, O.4    Kierulf, P.5
  • 27
    • 17744384489 scopus 로고    scopus 로고
    • The TETAMI trial: The safety and efficacy of subcutaneous enoxaparin versus intravenous unfractionated heparin and of tirofiban versus placebo in the treatment of acute myocardial infarction for patients not thrombolyzed: Methods and design
    • Cohen M, Maritz F, Gensini GF, Danchin N, Timerman A, Huber K, Gurfinkel EP, White H, Fox KAA, Vittori L, Le-Louer V, Bigonzi F. The TETAMI trial: the safety and efficacy of subcutaneous enoxaparin versus intravenous unfractionated heparin and of tirofiban versus placebo in the treatment of acute myocardial infarction for patients not thrombolyzed: methods and design. J Thromb Thrombolysis. 2000;10:241-246.
    • (2000) J Thromb Thrombolysis , vol.10 , pp. 241-246
    • Cohen, M.1    Maritz, F.2    Gensini, G.F.3    Danchin, N.4    Timerman, A.5    Huber, K.6    Gurfinkel, E.P.7    White, H.8    Fox, K.A.A.9    Vittori, L.10    Le-Louer, V.11    Bigonzi, F.12
  • 28
    • 0034469219 scopus 로고    scopus 로고
    • Low molecular weight heparin for treatment of acute myocardial infarction (FAMI): Fragmin (dalteparin sodium) in acute myocardial infarction
    • Kakkar VV, Iyengar SS, De Lorenzo F, Hargreaves JR, Kadziola ZA, for the FAMI Investigator Group. Low molecular weight heparin for treatment of acute myocardial infarction (FAMI): Fragmin (dalteparin sodium) in acute myocardial infarction. Indian Heart J. 2000;52:533-539.
    • (2000) Indian Heart J , vol.52 , pp. 533-539
    • Kakkar, V.V.1    Iyengar, S.S.2    De Lorenzo, F.3    Hargreaves, J.R.4    Kadziola, Z.A.5
  • 29
    • 0036223605 scopus 로고    scopus 로고
    • Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: The ASSENT-3 randomised trial in acute myocardial infarction
    • Visconti LO, for the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT-3) Investigators. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. Ital Heart J Suppl. 2002;3:245-246.
    • (2002) Ital Heart J Suppl , vol.3 , pp. 245-246
    • Visconti, L.O.1
  • 30
    • 0041467732 scopus 로고    scopus 로고
    • ST segment resolution in ASSENT 3: Insights into the role of three different treatment strategies for acute myocardial infarction
    • Armstrong PW, Wagner G, Goodman SG, Van de Werf F, Granger C, Wallentin L, Fu Y. ST segment resolution in ASSENT 3: insights into the role of three different treatment strategies for acute myocardial infarction. Eur Heart J. 2003;24:1515-1522.
    • (2003) Eur Heart J , vol.24 , pp. 1515-1522
    • Armstrong, P.W.1    Wagner, G.2    Goodman, S.G.3    Van De Werf, F.4    Granger, C.5    Wallentin, L.6    Fu, Y.7
  • 31
    • 10744232388 scopus 로고    scopus 로고
    • The safety and efficacy of subcutaneous enoxaparin versus intravenous unfractionated heparin and tirofiban versus placebo in the treatment of acute ST-segment elevation myocardial infarction patients ineligible for reperfusion (TETAMI): A randomized trial
    • Cohen M, Gensini GF, Maritz F, Gurfinkel EP, Huber K, Timerman A, Krzeminska-Pakula M, Danchin N, White HD, Santopinto J, Bigonzi F, Hecquet C, Vittori L, for the TETAMI Investigators. The safety and efficacy of subcutaneous enoxaparin versus intravenous unfractionated heparin and tirofiban versus placebo in the treatment of acute ST-segment elevation myocardial infarction patients ineligible for reperfusion (TETAMI): a randomized trial. J Am Coll Cardiol. 2003;42:1348-1356.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1348-1356
    • Cohen, M.1    Gensini, G.F.2    Maritz, F.3    Gurfinkel, E.P.4    Huber, K.5    Timerman, A.6    Krzeminska-Pakula, M.7    Danchin, N.8    White, H.D.9    Santopinto, J.10    Bigonzi, F.11    Hecquet, C.12    Vittori, L.13
  • 32
    • 3042811613 scopus 로고    scopus 로고
    • Efficacy of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: One-year follow-up results of the Assessment of the Safety of a New Thrombolytic-3 (ASSENT-3) randomized trial in acute myocardial infarction
    • Sinnaeve PR, Alexander JH, Bogaerts K, Belmans A, Wallentin L, Armstrong P, Adgey JA, Tendera M, Diaz R, Soares-Piegas L, Vahanian A, Granger CB, Van De Werf FJ. Efficacy of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: one-year follow-up results of the Assessment of the Safety of a New Thrombolytic-3 (ASSENT-3) randomized trial in acute myocardial infarction. Am Heart J. 2004;147:993-998.
    • (2004) Am Heart J , vol.147 , pp. 993-998
    • Sinnaeve, P.R.1    Alexander, J.H.2    Bogaerts, K.3    Belmans, A.4    Wallentin, L.5    Armstrong, P.6    Adgey, J.A.7    Tendera, M.8    Diaz, R.9    Soares-Piegas, L.10    Vahanian, A.11    Granger, C.B.12    Van De Werf, F.J.13
  • 33
    • 16544387480 scopus 로고    scopus 로고
    • Streptokinase and enoxaparin in the pre-hospital management of the ST-segment elevation acute myocardial infarction
    • Tatu-Chitoiu G, Oprisan M, Cismara O, Marinescu R, Marinescu A. Streptokinase and enoxaparin in the pre-hospital management of the ST-segment elevation acute myocardial infarction. Rom J Intern Med. 2002;40:11-25.
    • (2002) Rom J Intern Med , vol.40 , pp. 11-25
    • Tatu-Chitoiu, G.1    Oprisan, M.2    Cismara, O.3    Marinescu, R.4    Marinescu, A.5
  • 36
    • 0025687989 scopus 로고
    • Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction
    • Bleich SD, Nichols TC, Schumacher RR, Cooke DH, Tate DA, Teichman SL. Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction. Am J Cardiol. 1990;66:1412-1417.
    • (1990) Am J Cardiol , vol.66 , pp. 1412-1417
    • Bleich, S.D.1    Nichols, T.C.2    Schumacher, R.R.3    Cooke, D.H.4    Tate, D.A.5    Teichman, S.L.6
  • 37
    • 0028319315 scopus 로고
    • Influence of heparin on fibrinogen and D-dimer plasma levels in acute myocardial infarction treated with streptokinase
    • Salvioni A, Marenzi GC, Agostoni P, Grazi S, Guazzi MD. Influence of heparin on fibrinogen and D-dimer plasma levels in acute myocardial infarction treated with streptokinase. Eur Heart J. 1994;15:654-659.
    • (1994) Eur Heart J , vol.15 , pp. 654-659
    • Salvioni, A.1    Marenzi, G.C.2    Agostoni, P.3    Grazi, S.4    Guazzi, M.D.5
  • 39
    • 0035115802 scopus 로고    scopus 로고
    • The low-molecular-weight heparin dalteparin as adjuvant therapy in acute myocardial infarction: The ASSENT PLUS study
    • Wallentin L, Dellborg M, Lindahl B, Nilsson T, Pehrsson K, Swahn E. The low-molecular-weight heparin dalteparin as adjuvant therapy in acute myocardial infarction: the ASSENT PLUS study. Clin Cardiol. 2001;24(suppl 3):I12-I14.
    • (2001) Clin Cardiol , vol.24 , Issue.3 SUPPL.
    • Wallentin, L.1    Dellborg, M.2    Lindahl, B.3    Nilsson, T.4    Pehrsson, K.5    Swahn, E.6
  • 40
    • 0036474429 scopus 로고    scopus 로고
    • Influence on coagulation activity by subcutaneous LMW heparin as an adjuvant treatment to fibrinolysis in acute myocardial infarction
    • Frostfeldt G, Gustavsson G, Lindahl B, Nygren A, Siegbahn A, Wallentin L. Influence on coagulation activity by subcutaneous LMW heparin as an adjuvant treatment to fibrinolysis in acute myocardial infarction. Thromb Res. 2002;105:193-199.
    • (2002) Thromb Res , vol.105 , pp. 193-199
    • Frostfeldt, G.1    Gustavsson, G.2    Lindahl, B.3    Nygren, A.4    Siegbahn, A.5    Wallentin, L.6
  • 41
    • 0033920805 scopus 로고    scopus 로고
    • Low-molecular-weight heparins in acute myocardial infarction: Rationale and results of a pilot study
    • Ross AM, Coyne K, Hammond M, Lundergan CF. Low-molecular-weight heparins in acute myocardial infarction: rationale and results of a pilot study. Clin Cardiol. 2000;23:483-485.
    • (2000) Clin Cardiol , vol.23 , pp. 483-485
    • Ross, A.M.1    Coyne, K.2    Hammond, M.3    Lundergan, C.F.4
  • 42
    • 0023195094 scopus 로고
    • Randomized factorial trial of high-dose intravenous streptokinase, of oral aspirin and of intravenous heparin in acute myocardial infarction: ISIS (International Studies of Infarct Survival) pilot study
    • ISIS (International Studies of Infarct Survival) Pilot Study Investigators. Randomized factorial trial of high-dose intravenous streptokinase, of oral aspirin and of intravenous heparin in acute myocardial infarction: ISIS (International Studies of Infarct Survival) pilot study. Eur Heart J. 1987;8:634-642.
    • (1987) Eur Heart J , vol.8 , pp. 634-642
  • 44
    • 0001272209 scopus 로고
    • Infusion of heparin conjunct to streptokinase accelerates reperfusion of acute myocardial infarction: Results of a double blind randomized study (OSIRIS)
    • Col J, Decoster O, Hanique G, Delligne B, Boland J, Pirenne B, Cheron P, Renkin J. Infusion of heparin conjunct to streptokinase accelerates reperfusion of acute myocardial infarction: results of a double blind randomized study (OSIRIS). Circulation. 1992;86(suppl 1):259a.
    • (1992) Circulation , vol.86 , Issue.1 SUPPL.
    • Col, J.1    Decoster, O.2    Hanique, G.3    Delligne, B.4    Boland, J.5    Pirenne, B.6    Cheron, P.7    Renkin, J.8
  • 46
    • 0030817121 scopus 로고    scopus 로고
    • Randomized trial of low molecular weight heparin (dalteparin) in prevention of left ventricular thrombus formation and arterial embolism after acute anterior myocardial infarction: The Fragmin in Acute Myocardial Infarction (FRAMI) Study
    • Kontny F, Dale J, Abildgaard U, Pedersen TR. Randomized trial of low molecular weight heparin (dalteparin) in prevention of left ventricular thrombus formation and arterial embolism after acute anterior myocardial infarction: the Fragmin in Acute Myocardial Infarction (FRAMI) Study. J Am Coll Cardiol. 1997;30:962-969.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 962-969
    • Kontny, F.1    Dale, J.2    Abildgaard, U.3    Pedersen, T.R.4
  • 47
    • 0033101758 scopus 로고    scopus 로고
    • Low molecular weight heparin (dalteparin) as adjuvant treatment of thrombolysis in acute myocardial infarction - A pilot study: Biochemical Markers in Acute Coronary Syndromes (BIOMACS II)
    • Frostfeldt G, Ahlberg G, Gustafsson G, Helmius G, Lindahl B, Nygren A, Siegbahn A, Swahn E, Venge P, Wallentin L. Low molecular weight heparin (dalteparin) as adjuvant treatment of thrombolysis in acute myocardial infarction - a pilot study: Biochemical Markers in Acute Coronary Syndromes (BIOMACS II). J Am Coll Cardiol. 1999;33:627-633.
    • (1999) J Am Coll Cardiol , vol.33 , pp. 627-633
    • Frostfeldt, G.1    Ahlberg, G.2    Gustafsson, G.3    Helmius, G.4    Lindahl, B.5    Nygren, A.6    Siegbahn, A.7    Swahn, E.8    Venge, P.9    Wallentin, L.10
  • 48
    • 0036669066 scopus 로고    scopus 로고
    • Improved reperfusion and clinical outcome with enoxaparin as an adjuvant to streptokinase thrombolysis in acute myocardial infarction: The AMI-SK study
    • Simoons M, Krzeminska-Pakula M, Alonso A, Goodman SG, Kali A, Loos U, Gosset F, Louer V, Bigonzi F, for the AMI-SK Investigators. Improved reperfusion and clinical outcome with enoxaparin as an adjuvant to streptokinase thrombolysis in acute myocardial infarction: The AMI-SK study. Eur Heart J. 2002;23:1282-1290.
    • (2002) Eur Heart J , vol.23 , pp. 1282-1290
    • Simoons, M.1    Krzeminska-Pakula, M.2    Alonso, A.3    Goodman, S.G.4    Kali, A.5    Loos, U.6    Gosset, F.7    Louer, V.8    Bigonzi, F.9
  • 49
    • 0035949117 scopus 로고    scopus 로고
    • Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: The ASSENT-3 randomised trial in acute myocardial infarction
    • The Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. Lancet. 2001;358:605-613.
    • (2001) Lancet , vol.358 , pp. 605-613
  • 50
    • 0035822605 scopus 로고    scopus 로고
    • Randomized comparison of enoxaparin, a low-molecular-weight heparin, with unfractionated heparin adjunctive to recombinant tissue plasminogen activator thrombolysis and aspirin: Second Trial of Heparin and Aspirin Reperfusion Therapy (HART II)
    • Ross AM, Molhoek P, Lundergan C, Knudtson M, Draoui Y, Regalado L, Le Louer V, Bigonzi F, Schwartz W, De Jong E, Coyne K. Randomized comparison of enoxaparin, a low-molecular-weight heparin, with unfractionated heparin adjunctive to recombinant tissue plasminogen activator thrombolysis and aspirin: Second Trial of Heparin and Aspirin Reperfusion Therapy (HART II). Circulation. 2001;104:648-652.
    • (2001) Circulation , vol.104 , pp. 648-652
    • Ross, A.M.1    Molhoek, P.2    Lundergan, C.3    Knudtson, M.4    Draoui, Y.5    Regalado, L.6    Le Louer, V.7    Bigonzi, F.8    Schwartz, W.9    De Jong, E.10    Coyne, K.11
  • 51
    • 0036554907 scopus 로고    scopus 로고
    • Randomized comparison of enoxaparin with unfractionated heparin following fibrinolytic therapy for acute myocardial infarction
    • Baird SH, Menown IBA, McBride SJ, Trouton TG, Wilson C. Randomized comparison of enoxaparin with unfractionated heparin following fibrinolytic therapy for acute myocardial infarction. Eur Heart J. 2002;23:627-632.
    • (2002) Eur Heart J , vol.23 , pp. 627-632
    • Baird, S.H.1    Menown, I.B.A.2    McBride, S.J.3    Trouton, T.G.4    Wilson, C.5
  • 53
    • 0038814322 scopus 로고    scopus 로고
    • Low molecular weight heparin (dalteparin) compared to unfractionated heparin as an adjunct to rt-PA (alteplase) for improvement of coronary artery patency in acute myocardial infarction: The ASSENT Plus study
    • Wallentin L, Bergstrand L, Dellborg M, Fellenius C, Granger CB, Lindahl B, Lins L-E, Nilsson T, Pehrsson K. Siegbahn A, Swahn E, for the ASSENT PLUS Investigators. Low molecular weight heparin (dalteparin) compared to unfractionated heparin as an adjunct to rt-PA (alteplase) for improvement of coronary artery patency in acute myocardial infarction: the ASSENT Plus study. Eur Heart J. 2003;24:897-908.
    • (2003) Eur Heart J , vol.24 , pp. 897-908
    • Wallentin, L.1    Bergstrand, L.2    Dellborg, M.3    Fellenius, C.4    Granger, C.B.5    Lindahl, B.6    Lins, L.-E.7    Nilsson, T.8    Pehrsson, K.9    Siegbahn, A.10    Swahn, E.11
  • 54
    • 0038447936 scopus 로고    scopus 로고
    • Efficacy and safety of tenecteplase in combination with the low-molecular-weight heparin enoxaparin or unfractionated heparin in the prehospital setting: The Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 PLUS randomized trial in acute myocardial infarction
    • Wallentin L, Goldstein P, Armstrong PW, Granger CB, Adgey AA, Arntz HR, Bogaerts K, Danays T, Lindahl B, Makijarvi M, Verbeugt F, Van de Werf F. Efficacy and safety of tenecteplase in combination with the low-molecular-weight heparin enoxaparin or unfractionated heparin in the prehospital setting: the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 PLUS randomized trial in acute myocardial infarction. Circulation. 2003;108:135-142.
    • (2003) Circulation , vol.108 , pp. 135-142
    • Wallentin, L.1    Goldstein, P.2    Armstrong, P.W.3    Granger, C.B.4    Adgey, A.A.5    Arntz, H.R.6    Bogaerts, K.7    Danays, T.8    Lindahl, B.9    Makijarvi, M.10    Verbeugt, F.11    Van De Werf, F.12
  • 55
    • 0033662123 scopus 로고    scopus 로고
    • Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the US from 1990 through 1999: The National Registry of Myocardial Infarction 1, 2 and 3
    • Rogers WJ, Canto JG, Lambrew CT, Tiefenbrunn AJ, Kinkaid B, Shoultz DA, Frederick PD, Every N. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the US from 1990 through 1999: the National Registry of Myocardial Infarction 1, 2 and 3. J Am Coll Cardiol. 2000;36:2056-2063.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 2056-2063
    • Rogers, W.J.1    Canto, J.G.2    Lambrew, C.T.3    Tiefenbrunn, A.J.4    Kinkaid, B.5    Shoultz, D.A.6    Frederick, P.D.7    Every, N.8
  • 56
    • 10744230459 scopus 로고    scopus 로고
    • Patterns of use of heparins in ACS: Correlates and hospital outcomes: The Global Registry of Acute Coronary Events (GRACE)
    • Klein W, Kraxner W, Hodl R, Steg PG, Budaj A, Gulba D, Sadiq I, van de Werf F, White K, Fox KA, for the GRACE Investigators. Patterns of use of heparins in ACS: correlates and hospital outcomes: the Global Registry of Acute Coronary Events (GRACE). Thromb Haemost. 2003;90:519-527.
    • (2003) Thromb Haemost , vol.90 , pp. 519-527
    • Klein, W.1    Kraxner, W.2    Hodl, R.3    Steg, P.G.4    Budaj, A.5    Gulba, D.6    Sadiq, I.7    Van De Werf, F.8    White, K.9    Fox, K.A.10
  • 59
    • 0343798542 scopus 로고    scopus 로고
    • Trial of abciximab with and without low-dose reteplase for acute myocardial infarction
    • Strategies for Patency Enhancement in the Emergency Department (SPEED) Group. Trial of abciximab with and without low-dose reteplase for acute myocardial infarction. Circulation. 2000;101:2788-2794.
    • (2000) Circulation , vol.101 , pp. 2788-2794
  • 61
    • 0348109326 scopus 로고    scopus 로고
    • Recurrent cardiac ischemic events early after discontinuation of short-term heparin treatment in acute coronary syndromes: Results from the Thrombolysis in Myocardial Infarction (TIMI) 11B and Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events (ESSENCE) studies
    • Bijsterveld NR, Peters RJ, Murphy SA, Bernink PJ, Tijssen JG, Cohen M. Recurrent cardiac ischemic events early after discontinuation of short-term heparin treatment in acute coronary syndromes: results from the Thrombolysis in Myocardial Infarction (TIMI) 11B and Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events (ESSENCE) studies. J Am Coll Cardiol. 2003;42:2083-2089.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 2083-2089
    • Bijsterveld, N.R.1    Peters, R.J.2    Murphy, S.A.3    Bernink, P.J.4    Tijssen, J.G.5    Cohen, M.6
  • 62
    • 14844310378 scopus 로고    scopus 로고
    • Enoxaparin versus unfractionated heparin as antithrombin therapy in patients receiving fibrinolysis for ST-elevation myocardial infarction: Design and rationale for the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thrombolysis in Myocardial Infarction study 25 (ExTRACT-TIMI 25)
    • Antman EM, Morrow DA, McCabe CH, Jiang F, White HD, Fox KA, Sharma D, Chew P, Braunwald E, for the ExTRACT-TIMI 25 Investigators. Enoxaparin versus unfractionated heparin as antithrombin therapy in patients receiving fibrinolysis for ST-elevation myocardial infarction: design and rationale for the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thrombolysis in Myocardial Infarction study 25 (ExTRACT-TIMI 25). Am Heart J. 2005;149:217-226.
    • (2005) Am Heart J , vol.149 , pp. 217-226
    • Antman, E.M.1    Morrow, D.A.2    McCabe, C.H.3    Jiang, F.4    White, H.D.5    Fox, K.A.6    Sharma, D.7    Chew, P.8    Braunwald, E.9
  • 63
    • 0026607185 scopus 로고
    • ISIS-3: A randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41,299 cases of suspected acute myocardial infarction
    • ISIS-3 (Third International Study of Infarct Survival) Collaborative Group. ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41,299 cases of suspected acute myocardial infarction. Lancet. 1992;339:753-770.
    • (1992) Lancet , vol.339 , pp. 753-770
  • 64
    • 0032731676 scopus 로고    scopus 로고
    • Antithrombin agents as adjuncts to thrombolytic therapy
    • French JK, White HD. Antithrombin agents as adjuncts to thrombolytic therapy. J Thromb Thrombolysis. 1999;8:159-166.
    • (1999) J Thromb Thrombolysis , vol.8 , pp. 159-166
    • French, J.K.1    White, H.D.2
  • 67
    • 0037006402 scopus 로고    scopus 로고
    • Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction: Findings from the Global Registry of Acute Coronary Events (GRACE)
    • Eagle KA, Goodman SG, Avezum A, Budaj A, Sullivan CM, López-Sendón J. for the GRACE Investigators. Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction: findings from the Global Registry of Acute Coronary Events (GRACE). Lancet. 2002;359:373-377.
    • (2002) Lancet , vol.359 , pp. 373-377
    • Eagle, K.A.1    Goodman, S.G.2    Avezum, A.3    Budaj, A.4    Sullivan, C.M.5    López-Sendón, J.6
  • 69
    • 0037176525 scopus 로고    scopus 로고
    • Direct thrombin inhibitors in acute coronary syndromes: Principal results of a meta-analysis based on individual patients' data
    • Direct Thrombin Inhibitor Trialists' Collaborative Group. Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data. Lancet. 2002;359:294-302.
    • (2002) Lancet , vol.359 , pp. 294-302
  • 70
    • 0035651983 scopus 로고    scopus 로고
    • Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: The HERO-2 randomised trial
    • Hirulog and Early Reperfusion or Occlusion (HERO-2) Trial Investigators. Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial. Lancet. 2001;358:1855-1863.
    • (2001) Lancet , vol.358 , pp. 1855-1863


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