-
1
-
-
34447307795
-
Background Incidence of Elevated Liver Aminotransferases in Pulmonary Arterial Hypertension PAH.: Results from 4 Placebo-Controlled Clinical Trials
-
International Conference. San Diego, CA
-
Abbott SD, Fagan-Smith E, Coyne TC 2006. Background Incidence of Elevated Liver Aminotransferases in Pulmonary Arterial Hypertension PAH.: Results from 4 Placebo-Controlled Clinical Trials. Proceedings of the American Thoracic Society 2006 International Conference. San Diego, CA.
-
(2006)
Proceedings of the American Thoracic Society
-
-
Abbott, S.D.1
Fagan-Smith, E.2
Coyne, T.C.3
-
2
-
-
34249853651
-
-
Prescribing information [online, Updated August 2004; Last accessed 8 December 2004. URL
-
Actellion Tracleer® bosentan. 2004. Prescribing information [online]. Updated August 2004; Last accessed 8 December 2004. URL: http://www.tracleer.com/TRALibrary/TRALib004/ TRALib004PrescribingInfo.html.
-
(2004)
Actellion Tracleer® bosentan
-
-
-
3
-
-
0034809997
-
Medical therapy of pulmonary hypertension. An overview of treatment and goals
-
ix
-
Barst RJ. 2001. Medical therapy of pulmonary hypertension. An overview of treatment and goals. Clin Chest Med, 22:509-15, ix.
-
(2001)
Clin Chest Med
, vol.22
, pp. 509-515
-
-
Barst, R.J.1
-
4
-
-
33646255654
-
-
Barst RJ, Langleben D, Badesch D, et al; O. B. O. T. S.-S. 2006. Treatment of pulmonary arterial hypertension with the selective endothelin - a receptor antagonist sitaxsentan. J Am Coll Cardiol, 47:2049-56.
-
Barst RJ, Langleben D, Badesch D, et al; O. B. O. T. S.-S. 2006. Treatment of pulmonary arterial hypertension with the selective endothelin - a receptor antagonist sitaxsentan. J Am Coll Cardiol, 47:2049-56.
-
-
-
-
6
-
-
0036283401
-
Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension:open-label pilot study
-
Barst RJ, Rich S, Widlitz A, et al. 2002. Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension:open-label pilot study. Chest, 121:1860-8.
-
(2002)
Chest
, vol.121
, pp. 1860-1868
-
-
Barst, R.J.1
Rich, S.2
Widlitz, A.3
-
7
-
-
0030031888
-
A comparison of continuous intravenous epoprostenol prostacyclin. with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group
-
Barst RJ, Rubin LJ, Long WA, et al. 1996. A comparison of continuous intravenous epoprostenol prostacyclin. with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N Engl J Med, 334:296-302.
-
(1996)
N Engl J Med
, vol.334
, pp. 296-302
-
-
Barst, R.J.1
Rubin, L.J.2
Long, W.A.3
-
8
-
-
27644544637
-
(A role for combination therapy in pulmonary arterial hypertension]
-
Behr J, Borst MM, Winkler J, et al. 2005. (A role for combination therapy in pulmonary arterial hypertension]. Pneumologie, 59:730-5.
-
(2005)
Pneumologie
, vol.59
, pp. 730-735
-
-
Behr, J.1
Borst, M.M.2
Winkler, J.3
-
9
-
-
0033537345
-
Endothelin antagonists
-
Benigni A, Remuzzi G. 1999. Endothelin antagonists. Lancet, 353:133-8.
-
(1999)
Lancet
, vol.353
, pp. 133-138
-
-
Benigni, A.1
Remuzzi, G.2
-
10
-
-
0035818316
-
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension:a randomised placebo-controlled study
-
Channick RN, Simonneau G, Sitbon, et al. 2001. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension:a randomised placebo-controlled study. Lancet, 358:1119-23.
-
(2001)
Lancet
, vol.358
, pp. 1119-1123
-
-
Channick, R.N.1
Simonneau, G.2
Sitbon3
-
11
-
-
33645047236
-
Warfarin management in pulmonary arterial hypertension is similar between bosentan, placebo, and sitaxsentan
-
Coyne TC, Dixon RA. 2005. Warfarin management in pulmonary arterial hypertension is similar between bosentan, placebo, and sitaxsentan. Chest, 128:366S.
-
(2005)
Chest
, vol.128
-
-
Coyne, T.C.1
Dixon, R.A.2
-
13
-
-
0036671213
-
Classification of endothelin receptors and antagonists in clinical development
-
Davenport AP, Battistini B. 2002. Classification of endothelin receptors and antagonists in clinical development. Clin Sci Lond, 103(Suppl 48):1S-3S.
-
(2002)
Clin Sci Lond
, vol.103
, Issue.SUPPL. 48
-
-
Davenport, A.P.1
Battistini, B.2
-
14
-
-
10944231356
-
Clinical pharmacology of bosentan, a dual endothelin receptor antagonist
-
Dingemanse J, Van Giersbergen PL. 2004. Clinical pharmacology of bosentan, a dual endothelin receptor antagonist. Clin Pharmacokinet, 43:1089-115.
-
(2004)
Clin Pharmacokinet
, vol.43
, pp. 1089-1115
-
-
Dingemanse, J.1
Van Giersbergen, P.L.2
-
15
-
-
20444470139
-
The 6-min walk test 6MW. as an efficacy endpoint in pulmonary arterial hypertension clinical trials:demonstration of a ceiling effect
-
Frost AE, Langleben D, Oudiz R, et al. 2005. The 6-min walk test 6MW. as an efficacy endpoint in pulmonary arterial hypertension clinical trials:demonstration of a ceiling effect. Vascul Pharmacol, 43:36-9.
-
(2005)
Vascul Pharmacol
, vol.43
, pp. 36-39
-
-
Frost, A.E.1
Langleben, D.2
Oudiz, R.3
-
16
-
-
0027324745
-
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
-
Giaid A, Yanagisawa M, Langleben D, et al. 1993. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med, 328:1732-9.
-
(1993)
N Engl J Med
, vol.328
, pp. 1732-1739
-
-
Giaid, A.1
Yanagisawa, M.2
Langleben, D.3
-
17
-
-
25844531004
-
Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases
-
Girgis RE, Mathai SC, Krishnan JA, et al. 2005. Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases. J Heart Lung Transplant, 24:1626-31.
-
(2005)
J Heart Lung Transplant
, vol.24
, pp. 1626-1631
-
-
Girgis, R.E.1
Mathai, S.C.2
Krishnan, J.A.3
-
19
-
-
11144304239
-
STRIDE 1:Effects of the selective ETA receptor antagonist, sitaxsentan sodium, in a patient population with pulmonary arterial hypertension that meets traditional inclusion criteria of previous pulmonary arterial hypertension trials
-
Langleben D, Brock T, Dixon R, et al. 2004a. STRIDE 1:Effects of the selective ETA receptor antagonist, sitaxsentan sodium, in a patient population with pulmonary arterial hypertension that meets traditional inclusion criteria of previous pulmonary arterial hypertension trials. J Cardiovasc Pharmacol, 44:S80-S84.
-
(2004)
J Cardiovasc Pharmacol
, vol.44
-
-
Langleben, D.1
Brock, T.2
Dixon, R.3
-
20
-
-
33645091308
-
Etiology-specific endothelin-1 clearance in human precapillary pulmonary hypertension
-
Langleben D, Dupuis J, Langleben I, et al. 2006. Etiology-specific endothelin-1 clearance in human precapillary pulmonary hypertension. Chest, 129:689-95.
-
(2006)
Chest
, vol.129
, pp. 689-695
-
-
Langleben, D.1
Dupuis, J.2
Langleben, I.3
-
21
-
-
6344240798
-
Sustained symptomatic, functional, and hemodynamic benefit with the selective endothelin-A receptor antagonist, sitaxsentan, in patients with pulmonary arterial hypertension:a 1-year follow-up study
-
Langleben D, Hirsch AM, Shalit E, et al. 2004b. Sustained symptomatic, functional, and hemodynamic benefit with the selective endothelin-A receptor antagonist, sitaxsentan, in patients with pulmonary arterial hypertension:a 1-year follow-up study. Chest, 126:1377-81.
-
(2004)
Chest
, vol.126
, pp. 1377-1381
-
-
Langleben, D.1
Hirsch, A.M.2
Shalit, E.3
-
22
-
-
33750007282
-
Sustained efficacy with the highly selective orally-active endothelin-A receptor antagonist, sitaxsentan, after two years of therapy in patients with pulmonary arterial hypertension
-
International Conference. San Diego, CA
-
Langleben D, Hirsch AM, Shalit E, et al. 2005. Sustained efficacy with the highly selective orally-active endothelin-A receptor antagonist, sitaxsentan, after two years of therapy in patients with pulmonary arterial hypertension. Proceedings of the American Thoracic Society 2005 International Conference. San Diego, CA.
-
(2005)
Proceedings of the American Thoracic Society
-
-
Langleben, D.1
Hirsch, A.M.2
Shalit, E.3
-
23
-
-
0037126044
-
Survival in primary pulmonary hypertension:the impact of epoprostenol therapy
-
Mclaughlin VV, Shillington A, Rich S. 2002. Survival in primary pulmonary hypertension:the impact of epoprostenol therapy. Circulation, 106:1477-82.
-
(2002)
Circulation
, vol.106
, pp. 1477-1482
-
-
Mclaughlin, V.V.1
Shillington, A.2
Rich, S.3
-
24
-
-
13844280943
-
Survival with firstline bosentan in patients with primary pulmonary hypertension
-
Mclaughlin VV Sitbon O, Badesch DB, et al. 2005. Survival with firstline bosentan in patients with primary pulmonary hypertension. Eur Respir J, 25:244-9.
-
(2005)
Eur Respir J
, vol.25
, pp. 244-249
-
-
Mclaughlin, V.V.1
Sitbon, O.2
Badesch, D.B.3
-
25
-
-
0034107636
-
Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing
-
Miyamoto S, Nagaya N, Satoh T, et al. 2000. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. Am J Respir Crit Care Med, 161:487-92.
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 487-492
-
-
Miyamoto, S.1
Nagaya, N.2
Satoh, T.3
-
26
-
-
34249858649
-
Functional class improvement with sitaxsentan in patients with Class II-IV pulmonary arterial hypertension PAH
-
International Conference. San Diego, CA
-
Oudiz R, Badesch D, Girgis RE, et al. 2006a. Functional class improvement with sitaxsentan in patients with Class II-IV pulmonary arterial hypertension PAH. Proceedings of the American Thoracic Society 2006 International Conference. San Diego, CA.
-
(2006)
Proceedings of the American Thoracic Society
-
-
Oudiz, R.1
Badesch, D.2
Girgis, R.E.3
-
27
-
-
29244477173
-
Cardiopulmonary exercise testing and six-minute walk correlations in pulmonary arterial hypertension
-
Oudiz RJ, Barst RJ, Hansen JE, et al. 2006b. Cardiopulmonary exercise testing and six-minute walk correlations in pulmonary arterial hypertension. Am J Cardiol, 97:123-6.
-
(2006)
Am J Cardiol
, vol.97
, pp. 123-126
-
-
Oudiz, R.J.1
Barst, R.J.2
Hansen, J.E.3
-
29
-
-
0023615359
-
Primary pulmonary hypertension. A national prospective study
-
Rich S, Dantzker DR, Ayres SM, et al. 1987. Primary pulmonary hypertension. A national prospective study. Ann Intern Med, 107:216-23.
-
(1987)
Ann Intern Med
, vol.107
, pp. 216-223
-
-
Rich, S.1
Dantzker, D.R.2
Ayres, S.M.3
-
30
-
-
0035171979
-
Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension
-
Rubens C, Ewert R, Halank M, et al. 2001. Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension. Chest, 120:1562-9.
-
(2001)
Chest
, vol.120
, pp. 1562-1569
-
-
Rubens, C.1
Ewert, R.2
Halank, M.3
-
31
-
-
0037149718
-
Bosentan therapy for pulmonary arterial hypertension
-
Rubin LJ, Badesch DB, Barst RJ, et al. 2002. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med, 346:896-903.
-
(2002)
N Engl J Med
, vol.346
, pp. 896-903
-
-
Rubin, L.J.1
Badesch, D.B.2
Barst, R.J.3
-
32
-
-
0037151645
-
Long-term intravenous epoprostenol infusion in primary pulmonary hypertension:prognostic factors and survival
-
Sitbon O, Humbert M, Nunes H, et al. 2002. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension:prognostic factors and survival. J Am Coll Cardiol, 40:780-8.
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 780-788
-
-
Sitbon, O.1
Humbert, M.2
Nunes, H.3
-
33
-
-
0033758617
-
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ETA. receptor antagonist
-
Tilton RG, Munsch CL, Sherwood SJ, et al. 2000. Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ETA. receptor antagonist. Pulm Pharmacol Ther, 13:87-97.
-
(2000)
Pulm Pharmacol Ther
, vol.13
, pp. 87-97
-
-
Tilton, R.G.1
Munsch, C.L.2
Sherwood, S.J.3
-
34
-
-
0030943903
-
Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist
-
Wu C, Chan MF, Stavros F, et al. 1997. Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist. J Med Chem, 40:1690-7.
-
(1997)
J Med Chem
, vol.40
, pp. 1690-1697
-
-
Wu, C.1
Chan, M.F.2
Stavros, F.3
-
35
-
-
0033523893
-
Endothelin antagonists:substituted mesitylcarboxamides with high potency and selectivity for ETA. receptors
-
Wu C, Decker ER, Blok N, et al. 1999. Endothelin antagonists:substituted mesitylcarboxamides with high potency and selectivity for ETA. receptors. J Med Chem, 42:4485-99.
-
(1999)
J Med Chem
, vol.42
, pp. 4485-4499
-
-
Wu, C.1
Decker, E.R.2
Blok, N.3
|