Unique aspects of lysine nutrition and metabolism

Journal of Nutrition

Volumn 137, Issue 6, 2007, Pages

  Benevenga, Norlin J ^a   Blemings, Kenneth P ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; LYSINE 2 OXOGLUTARATE REDUCTASE; OXIDOREDUCTASE; SACCHAROPINE DEHYDROGENASE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DIET SUPPLEMENTATION; HUMAN; LIVER; LIVER FUNCTION; MITOCHONDRION; NONHUMAN; OXIDATION; PIGLET; PROTEIN DEGRADATION; PROTEIN DIET; PROTEIN EXPRESSION; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN TRANSPORT; TISSUE;

RATTUS;

EID: 34249824285     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.6.1610s     Document Type: Conference Paper

References (29)

1. Bender AE. 1961. Determination of the nutritive value of proteins by chemical analysis. In Progress in meeting protein needs of infants and preschool children, Publ. 843. Washington, DC: National Academy of Sciences. p. 407-24.
2. Bender AE. Evaluation of protein quality. methodological considerations. Proc Nutr Soc. 1982;41:267-76.
3. Ousterhout LE. Survival time and biochemical changes in chicks fed diets lacking different essential amino acids. J Nutr. 1960;70:226-34.
4. Yang SP, Tilton KS, Ryland LL. Utilization of a delayed Lys or Trp supplement for protein repletion of rats. J Nutr. 1968;94:178-84.
5. Baker DH, Izquierdo OA. Effect of meal frequency and spaced crystalline Lys ingestion on the utilization of dietary Lys by chickens. Nutr Res. 1985;5:1103-12.
6. Gahl MJ, Benevenga NJ, Crenshaw TD. Rates of Lys catabolism are inversely related to rates of protein synthesis when measured concurrently in adult female rats induced to grow at different rates. J Nutr. 1998;128:1503-11.
7. Blemings KP, Gahl MJ, Crenshaw TD, Benevenga NJ. Recombinant bovine somatotropin decreases hepatic amino acid catabolism in female rats. J Nutr. 1996;126:1657-61.
8. Kiess AS, Stinefelt BM, Cantrell CM, Wilson ME, Klandorf H, Blemings KP. Lys α-ketoglutarate reductase activity appears to be post-transnationally regulated in mice fed high protein containing diets [abstract]. FASEB J. 2005;19:A438.
9. Stinefelt BM, Cantrell CM, Kiess AS, Blemings KP. RNA interference mediated decrease of α-aminoadipate γ-semialdehyde synthase mRNA in a murine hepatic cell line. FASEB J. 2005;19:A438-439.
10. Higgins AD, Silverstein JT, Wilson ME, Rexroad, III CE, Blemings KP. Starvation-induced alterations in hepatic Lys catabolism in different families of rainbow trout (Oncorhynchus mykiss). Fish Physiol Biochem. 2006;31:33-44.
11. Kiess AS, Stinefelt BM, Gentilin AJ, Wilson ME, Klandorf H, Blemings KP. Lys catabolism in chickens fed at or below their Lys requirement [abstract]. FASEB J. 2006;20:A1042.
12. Karchi H, Miron D, Ben-Yaacov S, Galili G. The Lys-dependent stimulation of Lys catabolism in tobacco seed required calcium and protein phosphorylation. Plant Cell. 1995;7:1963-70.
13. Higashino K, Tsukada K, Lieberman I. Saccharopine, a product of Lys breakdown by mammalian liver. Biochem Biophys Res Commun. 1965;20:285-90.
14. 14C] carbonate as tracer. Biochim Biophys Acta. 1974;354:29-38.
15. Blemings KP, Crenshaw TD, Swick RW, Benevenga NJ. Lys-α- ketoglutarate reductase and saccharopine dehydrogenase are located only in the mitochondrial matrix in rat liver. J Nutr. 1994;124:1215-21.
16. Chua N-H, Schmidt GW. Transport of proteins into mitochondria and chloroplasts. J Cell Biol. 1979;81:461-83.
17. Blemings KP, Crenshaw TD, Benevenga NJ. Mitochondrial Lys uptake limits Lys oxidation in rats fed diets containing 5, 20, or 60% casein. J Nutr. 1998;128:2427-34.
18. Hommes FA, Kitchings L, Eller AG. The uptake of ornithine and Lys by rat liver mitochondria. Biochem Med. 1983;30:313-21.
19. Fiermonte G, Dolce V, David L, Santorelli FM, Dionisi-Vici C, Palmieri F, Walker JE. The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization and tissue distribution of two human isoforms. J Biol Chem. 2003;278:32778-83.
20. Chu S-HW, Hegsted DM. Adaptive response of Lys and threonine degrading enzymes in adult rats. J Nutr. 1976;106:1089-96.
21. Foster AR, Scislowski PWD, Harris CI, Fuller MF. Metabolic response of liver Lys α-ketoglutarate reductase activity in rats fed Lys limiting or Lys excessive diets. Nutr Res. 1993;13:1433-43.
22. Wang S-H, Crosby LO, Nesheim MC. Effect of dietary excesses of Lys and arginine on the degradation of Lys by chicks. J Nutr. 1973;103:384-91.
23. Pink D, Elango R, Dixon WT, Ball RO. Regulation of Lys α-ketoglutarate reductase varies during postnatal stages of growth and development in the pig [abstract]. FASEB J. 2004;18:A539.
24. Rao VV, Pan X, Chang Y. Developmental changes of L-Lys α-ketoglutarate reductase in rat brain and liver. Comp Biochem Physiol. 1992;103B:221-4.
25. Manangi MK, Hoewing SFA, Engles JG, Higgins AD, Killefer J, Wilson ME, Blemings KP. Lys α-ketoglutarate reductase and Lys oxidation are distributed in the extrahepatic tissues of chickens. J Nutr. 2005;135:81-5.
26. Hutzler J, Dancis J. Conversion of Lys to saccharopine by human tissue. Biochim Biophys Acta. 1968;158:62-9.
27. Hutzler J, Dancis J. Lys α-ketoglutarate reductase in human tissues. Biochim Biophys Acta. 1975;377:42-51.
28. Trackman PC, Kagan HM. Nonpeptidyl amino inhibitors are substrates for lysyl oxidase. J Biol Chem. 1979;254:7831-6.
29. Murthy SN, Janardanasarma MK. Identification of L-amino acid/L-Lys a-amino acid oxidase in mouse brain. Mol Cell Biochem. 1999;197:13-23.