Lysine α-ketoglutarate reductase and lysine oxidation are distributed in the extrahepatic tissues of chickens

Journal of Nutrition

Volumn 135, Issue 1, 2005, Pages 81-85

  Manangi, Megharaja K ^a,b   Hoewing, Sara F A ^a,c   Engels, Juanita G ^a   Higgins, Angela D ^a   Killefer, John ^a,d   Wilson, Matthew E ^a   Blemings, Kenneth P ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b UNIVERSITY OF ARKANSAS   (United States)

^c VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Amino acid metabolism; Chickens; Lysine; Lysine ketoglutarate reductase

Indexed keywords

2 OXOGLUTARIC ACID; LYSINE OXIDASE; MESSENGER RNA;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; CHICKEN; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME METABOLISM; LIVER; NONHUMAN; OXIDATION; PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN INTAKE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; TISSUE HOMOGENATE;

ANIMALIA; GALLUS GALLUS;

EID: 11844251242     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.1.81     Document Type: Conference Paper

References (46)

1. National Research Council (1989) Recommended Dietary Allowance, 10th ed., p. 70. National Academy Press, Washington, DC.
2. Broquist, H. P. (1991) Lysine-pipecolic acid metabolic relationships in microbes and mammals. Annu. Rev. Nutr. 11: 435-448.
3. Higashino, K., Tsukada, K. & Lieberman, I. (1965) Saccharopine, a product of lysine breakdown by mammalian liver. Biochem. Biophys. Res. Commun. 20: 285-290.
4. Saunders, P. P. & Broquist, H. P. (1966) Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. J. Biol. Chem. 241: 3435-3440.
5. Higashino, K., Fujioka, M., Aoki, T. & Yamamura, Y. (1967) Metabolism of lysine in rat liver. Biochem. Biophys. Res. Commun. 29: 95-100.
6. Blemings, K. P., Crenshaw, T. D., Swick, R. W. & Benevenga, N. J. (1994) Lysine α-ketoglutarate reductase and saccharopine dehydrogenase are located only in the mitochondrial matrix in rat liver. J. Nutr. 124: 1215-1221.
7. Blemings, K. P., Crenshaw, T. D. & Benevenga, N. J. (1998) Mitochondrial lysine uptake limits hepatic lysine oxidation in rats fed diets containing 5, 20, or 60% casein. J. Nutr. 128: 2427-2434.
8. Grove, J. A. & Roghair, H. G. (1971) The metabolism of D-and L-lysine in the chicken. Arch. Biochem. Biophys. 144: 230-236.
9. Wang, S. & Nesheim, M. C. (1972) Degradation of lysine in chicks. J. Nutr. 102: 583-596.
10. Miller, L. L. (1962) The role of the liver and the non-hepatic tissues in the regulation of free amino acid levels in the blood. In: Amino Acid Pools - Distribution, Formation, and Function of Free Amino Acids (Holden, J. T., ed.), pp. 708-721. Elsevier, New York, NY.
11. Blemings, K. P., Gahl, M. J., Crenshaw, T. D. & Benevenga, N. J. (1996) Recombinant bovine somatotropin decreases hepatic amino acid catabolism in female rats. J. Nutr. 126: 1657-1661.
12. Walton, M. J., Cowey, C. B. & Adron, J. W. (1984) The effect of dietary lysine levels on growth and metabolism of rainbow trout. Br. J. Nutr. 52: 115-122.
13. Noda, C. & Ichihara, A. (1978) Purification and properties of L-lysine-δ-ketoglutarate reductase from rat liver mitochondria. Biochim. Biophys. Acta 525: 307-313.
14. Hutzler, J. & Dancis, J. (1975) Lysine-ketoglutarate reductase in human tissues. Biochim. Biophys. Acta 377: 42-51.
15. Muramatsu, K., Takada, R. & Uwa, K. (1984) Adaptive Responses of liver and kidney lysine-ketoglutarate reductase and lysine oxidation in rats fed graded levels of dietary lysine and casein. Agric. Biol. Chem. 48: 703-711.
16. Noda, C. & Ichihara, A. (1976) Control of ketogenesis from amino acids. IV. Tissue specificity in oxidation of leucine, tyrosine, and lysine. J. Biochem. 80: 1159-1164.
17. Hutzler, J. & Dancis, J. (1968) Conversion of lysine to saccharopine by human tissues. Biochim. Biphys. Acta 158: 62-69.
18. Edmonds, M. S. & Baker, D. H. (1987) Failure of excess dietary lysine to antagonize arginine in young pigs. J. Nutr. 117: 1396-1401.
19. Sacksteder, K. A., Biery, B. J., Morrell, J. C., Goodman, B. K., Geisbrecht, Cox, R. P., Gould, S. J. & Geraghty, M. T. (2000) Identification of the α-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia. Am. J. Hum. Genet. 66: 1736-1743.
20. Scislowski, P.W.D., Foster, A. R. & Fuller, M. F. (1994) Regulation of oxidative degradation of L-lysine in rat liver mitochondria. Biochem. J. 300: 887-891.
21. Mukhopadhyay, A., Mungre, S. M. & Deshmukh, D. R. (1990) Comparison of lysine and tryptophan catabolizing enzymes in rat and bovine liver. Experientia 46: 874-876.
22. Rao, V., Pan, X. & Chang, Y. (1992) Developmental changes of L-lysine-ketoglutarate reductase in rat brain and liver. Comp. Biochem. Physiol. 103B: 221-224.
23. Papes, F., Kemper, E. L., Cord-Neto, G., Langone, F. & Arruda, P. (1999) Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem. J. 344: 555-563.
24. Papes, F., Surpili, M. J., Langone, F., Trigo, J. R. & Arruda, P. (2001) The essential amino acid lysine acts as a precursor of glutamate in the mammalian central nervous system. FEBS Lett. 488: 34-38.
25. Blemings, K. P. (1990) Studies of Lysine Metabolism in Rats and Pigs. Master's thesis. University of Wisconsin, Madison, WI.
26. Benevenega, N. J., Haas, L. G. & Crenshaw, T. D. (2003) Accepted metabolic pathways do not predict the lack of recovery of free L-lysine in whole body and urine of piglets infused with a 7 fold excess of L-lysine. FASEB J. 17: A734 (abs.).
27. Pink, D., Dixon, W. T. & Ball, R. O. (2002) Lysine catabolism in swine: An enzymatic approach. FASEB J. 16: A258 (abs.).
28. Pink, D., Elango, R., Dixon, W. T. & Ball, R. O. (2003) Lysine catabolism in the neonatal piglet during postnatal stages of growth and development. FASEB J. 17: A702 (abs.).
29. Pink, D. Elango, R., Dixon, W. T. & Ball, R. O. (2004) Regulation of lysine α-ketoglutarate reductase varies during postnatal stages of growth and development in the pig. FASEB J. 18: A539 (abs.).
30. Struck, J. & Sizer, I. W. (1960) Oxidation of L-α-amino acids by chicken liver microsomes. Arch. Biochem. Biophys. 90: 22-30.
31. Boulanger, P. & Osteux, R. (1957) Action de la L-aminoacide- deshydrogenere. Du foie de dindon (Meleagris gallopavo L.) sur les acides amines basiques. Biochim. Biophys. Acta 21: 552-561.
32. Shinwari, M. A. & Falconer, I. R. (1967) Naturally occurring inhibition and activation of avian liver L-amino acid oxidase. Biochem. J. 104: 53P-54P.
33. Murthy, S. N. & Janardanasarma, M. K. (1999) Identification of L-amino acid/L-lysine α-amino oxidase in mouse brain. Mol. Cell. Biochem. 197: 13-23.
34. Trackman, P. C. & Kagan, H. M. (1979) Nonpeptidyl amine inhibitors are substrates of lysyl oxidase. J. Biol. Chem. 254: 7831-7836.
35. Persson, L. (1977) Evidence of decarboxylation of lysine by mammalian ornithine decarboxylase. Acta Physiol. Scand. 100: 424-429.
36. Pegg, A. E. & McGill, S. (1979) Decarboxylation of ornithine and lysine in rat tissues. Biochim. Biophys. Acta 568: 416-427.
37. van Goudoever, J. B., Stoll, B., Burrin, D. G. & Reeds, P. J. (2000) Adaptive regulation of intestinal lysine metabolism. Proc. Natl. Acad. Sci. U.S.A. 97: 11620-11625.
38. Markovitz, P. J., Chuang, D. T. & Cox, R. P. (1984) Familial hyperlysinemias - purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities. J. Biol. Chem. 259: 11643-11646.
39. Markovitz, P. J. & Chuang, D. T. (1987) The bifunctional aminoadipic semialdehyde synthase in lysine degradation - separation of reductase and dehydrogenase domains by limited proteolysis and column chromatography. J. Biol. Chem. 262: 9353-9358.
40. Chu, S. & Hegsted, D. M. (1976) Adaptive response of lysine and threonine degrading enzymes in adult rats. J. Nutr. 106: 1089-1096.
41. Foster, A. R., Scislowski, P.W.D., Harris, C. I. & Fuller, M. F. (1993) Metabolic response of liver lysine a-ketoglutarate reductase activity in rats fed lysine limiting or lysine excessive diets. Nutr. Res. 13: 1433-1443.
42. Wang, S., Crosby, L. O. & Nesheim, M. C. (1973) Effect of dietary excesses of lysine and arginine on the degradation of lysine by chicks. J. Nutr. 103: 384-391.
43. Miron, D., Ben-Yaacov, S., Karchi, H. & Galili, G. (1997) In vitro dephosphorylation inhibits the activity of soybean lysine-ketoglutarate reductase in a lysine regulated manner. Plant J. 12: 1453-1458.
44. Karchi, H., Miron, M., Ben-Yaacov, S. & Galili, G. (1995) The lysine-dependent stimulation of lysine catabolism in tobacco seed requires calcium and protein phosphorylation. Plant Cell 7: 1963-1970.
45. Kiess, A. S., Stinefelt, B. M., Cantrell, C. M., Higgins, A. D., Wilson, M. E., Klandorf, H. & Blemings, K. P. (2004) Regulation of hepatic lysine α-ketoglutarate reductase in mice fed high or adequate protein diets. FASEB J. 18: A539 (abs.).
46. Higgins, A. D., Silverstein, J. T., Wilson, M. E., Rexroad, C. E., III & Blemings, K. P. (2004) The effect of genetics and starvation on lysine catabolism in rainbow trout (Oncorhynchus mykiss) liver. FASEB J. 18: A539 (abs.).