Requirement for dendritic cells in the establishment of anti-phospholipid antibodies

Autoimmunity

Volumn 40, Issue 4, 2007, Pages 302-306

  Bondanza, Attilio ^a   Rovere Querini, Patrizia ^a   Zimmermann, Valérie S ^a   Balestrieri, Genesio ^b   Tincani, Angela ^b   Sabbadini, Maria Grazia ^a   Manfredi, Angelo A ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b SPEDALI CIVILI   (Italy)

Author keywords

2 glycoprotein 1; Apoptosis; Autoantibodies; dendritic cells; Systemic lupus erythematosus

Indexed keywords

BETA2 GLYCOPROTEIN 1; BETA2 GLYCOPROTEIN 1 ANTIBODY; EPITOPE; PHOSPHOLIPID ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; BLOOD SAMPLING; CELL MEMBRANE; CLINICAL FEATURE; CONTROLLED STUDY; COW; DENDRITIC CELL; DISEASE COURSE; FEMALE; IMMUNIZATION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PINOCYTOSIS; PROGENY; THYMOCYTE; URINALYSIS;

ANIMALS; ANTIBODIES, ANTIPHOSPHOLIPID; APOPTOSIS; BETA 2-GLYCOPROTEIN I; CATTLE; DENDRITIC CELLS; FEMALE; IMMUNIZATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; PINOCYTOSIS; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 34249813124     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930701356572     Document Type: Article

References (40)

1. Mahoney, JA and Rosen, A. (2005) Apoptosis and autoimmunity. Curr Opin Immunol, 17, pp. 583-588.
2. Skoberne, M., Beignon, AS, Larsson, M. and Bhardwaj, N. (2005) Apoptotic cells at the crossroads of tolerance and immunity. Curr Top Microbiol Immunol, 289, pp. 259-292.
3. Voll, RE, Herrmann, M., Roth, EA, Stach, C., Kalden, JR and Girkontaite, I. (1997) Immunosuppressive effects of apoptotic cells. Nature, 390, pp. 350-351.
4. Huynh, ML, Fadok, VA and Henson, PM (2002) Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest, 109, pp. 41-50.
5. Herrmann, M., Voll, RE, Zoller, OM, Hagenhofer, M., Ponner, BB and Kalden, JR (1998) Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum, 41, pp. 1241-1250.
6. Baumann, I., Kolowos, W., Voll, RE, Manger, B., Gaipl, U., Neuhuber, WL, Kirchner, T., Kalden, JR and Herrmann, M. (2002) Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum, 46, pp. 191-201.
7. Gaipl, US, Franz, S., Voll, RE, Sheriff, A., Kalden, JR and Herrmann, M. (2004) Defects in the disposal of dying cells lead to autoimmunity. Curr Rheumatol Rep, 6, pp. 401-407.
8. Botto, M., Dell'Agnola, C., Bygrave, AE, Thompson, EM, Cook, HT, Petry, F., Loos, M., Pandolfi, PP and Walport, MJ (1998) Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet, 19, pp. 56-59.
9. Taylor, PR, Carugati, A., Fadok, VA, Cook, HT, Andrews, M., Carroll, MC, Savill, JS, Henson, PM, Botto, M. and Walport, MJ (2000) A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med, 192, pp. 359-366.
10. Gershov, D., Kim, S., Brot, N. and Elkon, KB (2000) C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: Implications for systemic autoimmunity. J Exp Med, 192, pp. 1353-1364.
11. Rovere, P., Peri, G., Fazzini, F., Bottazzi, B., Doni, A., Bondanza, A., Zimmermann, VS, Garlanda, C., Fascio, U., Sabbadini, MG, Rugarli, C., Mantovani, A. and Manfredi, AA (2000) The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells. Blood, 96, pp. 4300-4306.
12. Quartier, P., Potter, PK, Ehrenstein, MR, Walport, MJ and Botto, M. (2005) Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro. Eur J Immunol, 35, pp. 252-260.
13. Kravitz, MS, Pitashny, M. and Shoenfeld, Y. (2005) Protective molecules-C-reactive protein (CRP), serum amyloid P (SAP), pentraxin3 (PTX3), mannose-binding lectin (MBL), and apolipoprotein A1 (Apo A1), and their autoantibodies: Prevalence and clinical significance in autoimmunity. J Clin Immunol, 25, pp. 582-591.
14. Baruah, P., Propato, A., Dumitriu, IE, Rovere-Querini, P., Russo, V., Fontana, R., Accapezzato, D., Peri, G., Mantovani, A., Barnaba, V. and Manfredi, AA (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood, 107, pp. 151-158.
15. Baruah, P., Dumitriu, IE, Peri, G., Russo, V., Mantovani, A., Manfredi, AA and Rovere-Querini, P. (2006) The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells. J Leukoc Biol, 80, pp. 87-95.
16. Mevorach, D. (2004) The role of death-associated molecular patterns in the pathogenesis of systemic lupus erythematosus. Rheum Dis Clin North Am, 30, pp. 487-504.
17. Dumitriu, IE, Baruah, P., Manfredi, AA, Bianchi, ME and Rovere-Querini, P. (2005) HMGB1: Guiding immunity from within. Trends Immunol, 26, pp. 381-387.
18. Mevorach, D., Zhou, JL, Song, X. and Elkon, KB (1998) Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med, 188, pp. 387-392.
19. Bondanza, A., Zimmermann, VS, Dell'Antonio, G., Cin, E Dal, Balestrieri, G., Tincani, A., Amoura, Z., Piette, J-C, Sabbadini, MG, Rovere-Querini, P. and Manfredi, AA (2004) Requirement of dying cells and environmental adjuvants for the induction of autoimmunity. Arthritis Rheum, 50, pp. 1549-1560.
20. Bondanza, A., Zimmermann, VS, Dell'Antonio, G., Cin, E Dal, Capobianco, A., Sabbadini, MG, Manfredi, AA and Rovere-Querini, P. (2003) Cutting edge: Dissociation between autoimmune response and clinical disease after vaccination with dendritic cells. J Immunol, 170, pp. 24-27.
21. Manfredi, AA, Sabbadini, MG and Rovere-Querini, P. (2005) Dendritic cells and the shadow line between autoimmunity and disease. Arthritis Rheum, 52, pp. 11-15.
22. Georgiev, M., Agle, MA, Ashany, D., Chu, JL and Elkon, KB (2005) Mature dendritic cells readily break tolerance in normal mice but do not lead to disease expression. Arthritis Rheum, 52, pp. 225-238.
23. Frisoni, L., McPhie, L., Colonna, L., Sriram, U., Monestier, M., Gallucci, S. and Caricchio, R. (2005) Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: A novel pathogenic pathway for autoimmunity?. J Immunol, 175, pp. 2692-2701.
24. Tzeng, TC, Suen, JL and Chiang, BL (2006) Dendritic cells pulsed with apoptotic cells activate self-reactive T-cells of lupus mice both in vitro and in vivo. Rheumatology, 45, pp. 1230-1237.
25. Colonna, L., Dinnall, JA, Shivers, DK, Frisoni, L., Caricchio, R. and Gallucci, S. (2006) Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus. Arthritis Res Ther, 8, p. R49.
26. Levine, JS, Subang, R., Koh, JS and Rauch, J. (1998) Induction of anti-phospholipid autoantibodies by beta2-glycoprotein I bound to apoptotic thymocytes. J Autoimmun, 11, pp. 413-424.
27. Balasubramanian, K., Chandra, J. and Schroit, AJ (1997) Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition. J Biol Chem, 272, pp. 31113-31117.
28. Manfredi, AA, Rovere, P., Heltai, S., Galati, G., Nebbia, G., Tincani, A., Balestrieri, G. and Sabbadini, MG (1998) Apoptotic cell clearance in systemic lupus erythematosus: II. Role for the beta2-glycoprotein I. Arthritis Rheum, 41, pp. 215-223.
29. Manfredi, AA, Rovere, P., Galati, G., Heltai, S., Bozzolo, E., Soldini, L., Davoust, J., Balestrieri, G., Tincani, A. and Sabbadini, MG (1998) Apoptotic cell clearance in systemic lupus erythematosus I. Opsonization by antiphospholipid antibodies. Arthritis Rheum, 41, pp. 205-214.
30. Cocca, BA, Seal, SN, D'Agnillo, P., Mueller, YM, Katsikis, PD, Rauch, J., Weigert, M. and Radic, MZ (2001) Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc Natl Acad Sci USA, 98, pp. 13826-13831.
31. Tincani, A., Gilburd, B., Abu-Shakra, M., Blank, M., Allegri, F., Ottaviani, R., Riboni, M., Meroni, PL, Balestrieri, G. and Shoenfeld, Y. (2002) Immunization of naive BALB/c mice with human beta2-glycoprotein I breaks tolerance to the murine molecule. Arthritis Rheum, 46, pp. 1399-1404.
32. Balasubramanian, K., Maiti, SN and Schroit, AJ (2005) Recruitment of beta-2-glycoprotein 1 to cell surfaces in extrinsic and intrinsic apoptosis. Apoptosis, 10, pp. 439-446.
33. Kuwana, M., Matsuura, E., Kobayashi, K., Okazaki, Y., Kaburaki, J., Ikeda, Y. and Kawakami, Y. (2005) Binding of beta 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells. Blood, 105, pp. 1552-1557.
34. Levine, JS, Subang, R., Nasr, SH, Fournier, S., Lajoie, G., Wither, J. and Rauch, J. (2006) Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosus. J Immunol, 177, pp. 6504-6516.
35. Rovere, P., Manfredi, AA, Vallinoto, C., Zimmermann, VS, Fascio, U., Balestrieri, G., Ricciardi-Castagnoli, P., Rugarli, C., Tincani, A. and Sabbadini, MG (1998) Dendritic cells preferentially internalize apoptotic cells opsonized by anti-beta2-glycoprotein I antibodies. J Autoimmun, 11, pp. 403-411.
36. Rovere, P., Sabbadini, MG, Vallinoto, C., Fascio, U., Rescigno, M., Crosti, MC, Castagnoli, P Ricciardi, Balestrieri, G., Tincani, A. and Manfredi, AA (1999) Dendritic cell presentation of antigens from apoptotic cells in a pro-inflammatory context: Role of opsonizing anti-beta 2 glycoprotein I antibodies. Arthritis Rheum, 42, pp. 1412-1420.
37. Bondanza, A., Sabbadini, MG, Pellegatta, F., Zimmermann, VS, Tincani, A., Balestrieri, G., Manfredi, AA and Rovere, P. (2000) Anti-beta2 glycoprotein I antibodies prevent the de-activation of platelets and sustain their phagocytic clearance. J Autoimmun, 15, pp. 469-477.
38. Bondanza, A., Zimmermann, VS, Rovere-Querini, P., Turnay, J., Dumitriu, IE, Stach, CM, Voll, RE, Gaipl, US, Bertling, W., Poschl, E., Kalden, JR, Manfredi, AA and Herrmann, M. (2004) Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo. J Exp Med, 200, pp. 1157-1165.
39. Rovere-Querini, P., Capobianco, A., Scaffidi, P., Valentinis, B., Catalanotti, F., Giazzon, M., Dumitriu, IE, Müller, S., Iannacone, M., Traversari, C., Bianchi, ME and Manfredi, AA (2004) HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep, 5, pp. 825-830.
40. Zimmermann, VS, Bondanza, A., Monno, A., Rovere-Querini, P., Corti, A. and Manfredi, AA (2004) TNF-alpha coupled to membrane of apoptotic cells favors the cross-priming to melanoma antigens. J Immunol, 172, pp. 2643-2650.