Glycine as a potent anti-angiogenic nutrient for tumor growth

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue SUPPL. 1, 2007, Pages

  Yamashina, Shunhei ^a   Ikejima, Kenichi ^a   Rusyn, Ivan ^b   Sato, Nobuhiro ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b University of North Carolina at Chapel Hill   (United States)

Author keywords

Angiogenesis; Calcium signal; Endothelial cell; Vascular endothelial growth factor

Indexed keywords

BUFFER; CALCIUM; CHLORIDE; CHLORIDE CHANNEL; GLYCINE; MESSENGER RNA; STRYCHNINE; VASCULOTROPIN;

CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER THERAPY; CELL GROWTH; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONFERENCE PAPER; ENDOTHELIUM CELL; HYPERPOLARIZATION; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; TUMOR GROWTH;

EID: 34249810960     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04655.x     Document Type: Conference Paper

References (18)

1. Bicknell R, Harris AL. Mechanisms and therapeutic implications of angiogenesis. Curr. Opin. Oncol. 1996 8 : 60 5.
2. Folkman J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 1971 285 : 1182 6.
3. Gastl G, Hermann T, Steurer M et al. Angiogenesis as a target for tumor treatment. Oncology 1997 54 : 177 84.
4. Veikkola T, Alitalo K. VEGFs, receptors and angiogenesis. Semin. Cancer Biol. 1999 9 : 211 20.
5. Kim KJ, Li B, Winer J et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 1993 362 : 841 4.
6. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999 13 : 9 22.
7. Folkman J. Tumor angiogenesis. Adv. Cancer Res. 1985 43 : 175 203.
8. Rajendra S, Lynch JW, Schofield PR. The glycine receptor. Pharmacol. Ther. 1997 73 : 121 46.
9. Ikejima K, Qu W, Stachlewitz RF, Thurman RG. Kupffer cells contain a glycine-gated chloride channel. Am. J. Physiol. 1997 272 : G1581 G1586.
10. Wheeler MD, Seabra V, Thurman RG. Molecular evidence for glycine-gated chloride channel in Kupffer cells. In : Wisse E, Knook DL, Wake K, eds. Cells of the Hepatic Sinusoid. Leiden, the Netherlands : Kupffer Cell Foundation, 1999 153 5.
11. Chung SC, McDonald TV, Gardner P. Inhibition by SK and F 96365 of Ca2+ current, IL-2 production and activation in T lymphocytes. Br. J. Pharmacol. 1994 113 : 861 8.
12. Wheeler MD, Stachlewitz RF, Ikejima K, Morrow AL, Ikejima K, Thurman RG. Glycine-gated chloride channels in neutrophils attenuate calcium influx and superoxide production. FASEB J. 2000 14 : 476 84.
13. Rose ML, Madren J, Bunzendahl H, Thurman RG. Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Carcinogenesis 1999 20 : 793 8.
14. Rose ML, Cattley RC, Dunn C, Wong V, Li X, Thurman RG. Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643. Carcinogenesis 1999 20 : 2075 81.
15. Folkman J. Angiogenesis: initiation and control. Ann. N.Y. Acad. Sci. 1982 401 : 212 27.
16. Xia P, Aiello LP, Ishii H et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J. Clin. Invest. 1996 98 : 2018 26.
17. Langosch D, Becker C-M, Betz H. The inhibitory glycine receptor: a ligand-gated chloride channel of the central nervous system. Eur. J. Biochem. 1990 194 : 1 8.
18. Grenningloh G, Pribilla I, Prior P et al. Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor. Neuron 1990 4 : 963 70.