Further Evidence for Co-Segregation between Pediatric Obsessive Compulsive Disorder and Attention Deficit Hyperactivity Disorder: A Familial Risk Analysis

Biological Psychiatry

Volumn 61, Issue 12, 2007, Pages 1388-1394

  Geller, Daniel ^a   Petty, Carter ^a   Vivas, Fe ^a   Johnson, Jessica ^a   Pauls, David ^a   Biederman, Joseph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Attention deficit hyperactivity disorder; child and adolescent; familial risk; genetic; obsessive compulsive disorder

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CLINICAL FEATURE; COMORBIDITY; CONTROLLED STUDY; FAMILIAL INCIDENCE; FEMALE; GENETIC RISK; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSESSIVE COMPULSIVE DISORDER; ONSET AGE; PRIORITY JOURNAL; RELATIVE; RISK ASSESSMENT; RISK FACTOR;

ADOLESCENT; AGE OF ONSET; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD OF IMPAIRED PARENTS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMANS; INTERVIEW, PSYCHOLOGICAL; MALE; OBSESSIVE-COMPULSIVE DISORDER; QUESTIONNAIRES; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 34249807891     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.09.026     Document Type: Article

References (65)

1. Andrews G., Stewart G., Allen R., and Henderson A. The genetics of six neurotic disorders: A twin study. J Affec Dis 19 (1990) 23-29
2. Andrews G., Stewart G., Morris-Yates A., Holt P., and Henderson A.S. Evidence for a general neurotic syndrome. Br J Psychiatry 157 (1990) 6-12
3. Bebbington P.E. Epidemiology of obsessive-compulsive disorder. Br J Psychiatry 173 (1998) 2-6
4. Biederman J., Faraone S.V., Mick E., Williamson S., Wilens T.E., Spencer T.J., et al. Clinical correlates of ADHD in females: Findings from a large group of girls ascertained from pediatric and psychiatric referral sources. J Am Acad Child Adolesc Psychiatry 38 (1999) 966-975
5. Biederman J., Faraone S., Milberger S., Guite J., Mick E., Chen L., et al. A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders. Arch Gen Psychiatry 53 (1996) 437-446
6. Biederman J., Faraone S.V., Keenan K., Benjamin J., Krifcher B., Moore C., et al. Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder: Patterns of comorbidity in probands and relatives in psychiatrically and pediatrically referred samples. Arch Gen Psychiatry 49 (1992) 728-738
7. Biederman J., Faraone S.V., Mick E., Spencer T., Wilens T., Kiely K., et al. High risk for ADHD in children of parents with childhood onset ADHD: A pilot study. Am J Psychiatry 152 (1995) 431-435
8. Biederman J., Faraone S.V., Wozniak J., and Monuteaux M.C. Parsing the association between bipolar, conduct, and substance use disorders: A familial risk analysis. Biol Psychiatry 48 (2000) 1037-1044
9. Biederman J., Mick E., Faraone S.V., Braaten E., Doyle A., Spencer T., et al. Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic. Am J Psychiatry 159 (2002) 36-42
10. Braaten E.B., Beiderman J., Monuteaux M.C., Mick E., Calhoun E., Cattan G., and Faraone S.V. Revisiting the association between attention deficit hyperactivity disorder and anxiety disorders: A familial risk analysis. Biol Psychiatry 53 (2003) 93-99
11. Carey G., and Gottesman I. Twin and family studies of anxiety, phobic, and obsessive disorders. In: Klien D., and Rabkin J. (Eds). Anxiety: New research and changing concepts (1981), Raven Press, New York 117-136
12. Comings D.E., and Comings B.G. A controlled study of Tourette syndrome. I. Attention-deficit disorder, learning disorders, and school problems. Am J Hum Genet 41 (1987) 701-741
13. Costello E., and Angold A. Epidemiology (1995), The Guilford Press, New York
14. Degonda M., Wyss M., and Angst J. The Zurich Study: XVIII. Obsessive-compulsive disorders and syndromes in the general population. E Arch Psychiatry Clin Neurosci 243 (1993) 16-22
15. Douglass H.M., Moffitt T.E., Dar R., McGee R., and Silva P. Obsessive-compulsive disorder in a birth cohort of 18-year-olds: Prevalence and predictors. J Am Acad Child Adolesc Psychiatry 34 (1995) 1424-1431
16. Doyle A., Faraone S.V., DuPre E.P., and Biederman J. Separating attention deficity hyperactivity disorder and learning disabilities in girls: A familial risk analysis. Am J Psychiatry 158 (2001) 1666-1672
17. Eapen V., Robertson M.M., Alsobrook II J.P., and Pauls D.L. Obsessive compulsive symptoms in Gilles de la Tourette syndrome and obsessive compulsive disorder: Differences by diagnosis and family history. Am J Med Genet 74 (1997) 432-438
18. Faraone S. Report from the fourth international meeting of the attention deficit hyperactivity disorder molecular genetics network. Am J Med Genet (Neuropsych Genet) 121B (2003) 55-59
19. Faraone S., Biederman J., Webber W., and Russell R. Psychiatric, neuropsychological, and psychosocial features of DSM-IV subtypes of attention-deficit/hyperactivity disorder: Results from a clinically referred sample. J Am Acad Child Adolesc Psychiatry 37 (1998) 185-193
20. Faraone S.V., Biederman J., Mick E., Williamson S., Wilens T., Spencer T., et al. Family study of girls with attention deficit hyperactivity disorder. Am J Psychiatry 157 (2000) 1077-1083
21. Flament M.F., Whitaker A., Rapoport J.L., Davies M., Berg C.Z., Kalikow K., et al. Obsessive compulsive disorder in adolescence: An epidemiological study. J Am Acad Child Adolesc Psychiatry 27 (1988) 764-771
22. Frankel M., Cummings J.L., Robertson M.M., Trimble M.R., Hill M.A., and Benson D.F. Obsessions and compulsions in Gilles de la Tourette's syndrome. Neurology 36 (1986) 378-382
23. Geller D.A., Biederman J., Faraone S.V., Cradock K., Hagermoser L., Zaman N., et al. Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: Fact or artifact?. J Am Acad Child Adolesc Psychiatry 41 (2002) 52-58
24. Geller D., Biederman J., Faraone S.V., Frazier J., Coffey B.J., Kim G., and Bellordre C.A. Clinical correlates of obsessive compulsive disorder in children and adolescents referred to specialized and nonspecialized clinical settings. Depression and Anxiety 11 (2000) 163-168
25. Geller D., Biederman J., Faraone S.V., Hagermoser L.M., Zaman N.K., Farrell C.F., et al. Does comorbid ADHD signal a developmental subtype of pediatric OCD?. In: Findling R., Brown P.A., Enright T., Figge K., and Nastro C.S. (Eds). Sci Proc Am Acad Child Adolesc Psychiatry (2002) San Francisco, Ca.
26. Geller D., Biederman J., Griffin S., Jones J., and Lefkowitz T.R. Comorbidity of juvenile obsessive-compulsive disorder with disruptive behavior disorders. J Am Acad Child Adolesc Psychiatry 35 (1996) 1637-1646
27. Geller D.A., Biederman J., Stewart S.E., Mullin B., Farrell C., Wagner K.D., et al. Impact of comorbidity on treatment response to paroxetine in pediatric obsessive compulsive disorder: Is the use of exclusion criteria empirically supported in randomized clinical trials?. J Am Acad Child Adolesc Psychopharmacology 13 (2003) S19-S29
28. Geller D.A., Coffey B., Faraone S., Hagermoser L., Zaman N.K., Farrell C.L., et al. Does comorbid attention-deficit/hyperactivity disorder impact the clinical expression of pediatric obsessive compulsive disorder. CNS Spectrums 8 (2003) 259-264
29. Geller D.A., Faraone S., Stein N., Farrell C., Mick E., Gianini L., et al. A family genetic study of OCD and ADHD in youth. In: Saxena K., Kowatch R., Leibenluft E., and Chang K. (Eds). Sci Proc Am Academy of Child and Adolescent Psychiatry (2003) Miami, FL.
30. Geller DA, Petty C, Vivas F, Johnson J, Pauls D, Biederman J (in press): Examining the relationship between obsessive compulsive disorder and attention deficit hyperactivity disorder in children and adolescents: A familial risk analysis. Biol Psychiatry.
31. Grados M.A., Riddle M.A., Samuels J.F., Liang K.Y., Hoehn-Saric R., Bienvenu O.J., et al. The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: The Hopkins OCD family study. Biol Psychiatry 50 (2001) 559-565
32. Hanna G., Fischer D., Chadha K., Himle J.A., and Van Etten M.L. Familial and sporadic subtypes of early-onset obsessive-compulsive disorder. Biol Psychiatry 57 (2005) 895-900
33. Hanna G.L. Demographic and clinical features of obsessive-compulsive disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry 34 (1995) 19-27
34. Hollander E. Obsessive-compulsive spectrum disorders: An overview. Psychiatric Annals 23 (1993) 355-358
35. Hollingshead A.B. Four Factor Index of Social Status (1975), Yale Press, New Haven
36. Hyde T.M., Aaronson B.A., Randolph C., Rickler K.C., and Weinberger D.R. Relationship of birth weight to the phenotypic expression of Gilles de la Tourette's syndrome in monozygotic twins. Neurology 42 (1992) 652-658
37. Jagger J., Prussof B., Cohen D., Kidd K., Carbonari C., and John K. The epidemiology of Tourette's syndrome. Schizophr Bullet 8 (1982) 267-278
38. Karno M., Golding J., Sorenson S., and Burnam A. The epidemiology of obsessive-compulsive disorder in five U.S. communities. Arch Gen Psychiatry 45 (1988) 1094-1099
39. Kessler R.C., Demler O., Frank R.G., Olfson M., Pincus H.A., Walters E.E., et al. Prevalence and treatment of mental disorders, 1990 to 2003. N Engl J Med 352 (2005) 2515-2523
40. Leckman J., Sholomskas D., Thompson W., Belanger A., and Weissman M. Best estimate of lifetime psychiatric diagnosis: A methodological study. Arch Gen Psychiatry 39 (1982) 879-883
41. Liang K.Y., and Zeger S.L. Longitudinal data analysis using generalized linear models. Biometrika 73 (1986) 13-22
42. Orvaschel H., and Puig-Antich J. Schedule for Affective Disorders and Schizophrenia for School-Age Children: Epidemiologic 4th Version (1987), Nova University, Center for Psychological Study, Ft. Lauderdale, FL
43. Orvaschel H., Walsh-Allis G., and Ye W.J. Psychopathology in children of parents with recurrent depression. J Abnorm Child Psychology 16 (1988) 17-28
44. Pauls D., Alsobrook II J., Goodman W., Rasmussen S., and Leckman J. A family study of obsessive-compulsive disorder. Am J Psychiatry 152 (1995) 76-84
45. Pauls D.L., Hurst C.R., Kruger S.D., Leckman J.F., Kidd K.K., and Cohen D.J. Gilles de la Tourette's syndrome and attention deficit disorder with hyperactivity: Evidence against a genetic relationship. Arch Gen Psychiatry 43 (1986) 1177-1179
46. Pauls D.L., Leckman J.F., and Cohen D.J. Familial relationship between Gilles de la Tourette's syndrome, attention deficit disorder, learning disabilities, speech disorders, and stuttering. J Am Acad Child Adolesc Psychiatry 32 (1993) 1044-1050
47. Pauls D.L., Mundo E., and Kennedy J.L. The pathophysiology and genetics of obsessive-compulsive disorder. In: Davis K.L., Charney D., Coyle J.T., and Nemeroff C. (Eds). Neuropsychopharmacology: The Fifth Generation of Progress (2002), Lippincott Williams & Wilkins, Philadelphia 1609-1619
48. Pauls D.L., Raymond C.L., Stevenson J.M., and Leckman J.F. A family study of Gilles de la Tourette syndrome. Am J Hum Genet 48 (1991) 154-163
49. Pauls D.L., Towbin K.E., Leckman J.F., Zahner G.E.P., and Cohen D.J. Gilles de la Tourette's syndrome and obsessive-compulsive disorder: Evidence supporting a genetic relationship. Arch Gen Psychiatry 43 (1986) 1180-1182
50. Price R.A., Leckman J.F., Pauls D.L., Cohen D.J., and Kidd K.K. Gilles de la Tourette's syndrome: Tics and central nervous system stimulants in twins and nontwins. Neurology 36 (1986) 232-237
51. Puig-Antich J., and Rabinovich H. Relationship between affective and anxiety disorders in childhood. In: Gittelman R. (Ed). Anxiety Disorders of Childhood (1986), Guilford Press, New York 136-156
52. Riddle M.A., Scahill L., King R., Hardin M.T., Towbin K.E., Ort S.I., et al. Obsessive compulsive disorder in children and adolescents: Phenomenology and family history. J Am Acad Child Adolesc Psychiatry 29 (1990) 766-772
53. Robertson M., Trimble M., and Lees A. The psychopathology of the Gilles de la Tourette syndrome: A phenomenological analysis. Br J Psychology 152 (1988) 383-390
54. Rosario-Campos M.C., Leckman J.F., Curi M., Quatrano S., Katsovitch L., Miguel E.C., and Pauls D.L. A family study of early-onset obsessive-compulsive disorder. Am J Med Genet 136 (2005) 92-97
55. Rosenbaum J.F., Biederman J., Hirshfeld-Becker D.R., Kagan J., Snidman N., Friedman D., et al. A controlled study of behavioral inhibition in children of parents with panic disorder and depression. Am J Psychiatry 157 (2000) 2002-2010
56. Spitzer R.L., Williams J.B.W., Gibbon M., and First M.B. The structured clinical interview for DSM-III-R (SCID). Arch Gen Psychiatry 49 (1992) 624-629
57. Stata Corporation. Stata Reference Manual: Release 5 (1997), Stata Corporation, College Station, TX
58. Swedo S., and Rapoport J. Phenomenology and differential diagnosis of obsessive-compulsive disorder in children and adolescents. In: Rapoport J. (Ed). Obsessive-Compulsive Disorder in Children and Adolescents (1989), American Psychiatric Press, Washington 13-32
59. Sylvester C.E., Hyde T.S., and Reichler R.J. Clinical psychopathology among children of adults with panic disorder. In: Dunner D.L., Gershon E.S., and Barrett J.E. (Eds). Relatives at Risk for Mental Disorders (1988), Raven Press, Ltd, New York 87-102
60. Thomsen P. Obsessive-compulsive disorder in children and adolescents: Self-reported obsessive-compulsive behaviour in pupils in Denmark. Acta Psychiatrica Scandinavica 88 (1993) 212-217
61. Thomsen P., and Mikkelsen H. Development of personality disorders in children and adolescents with obsessive-compulsive disorder. Acta Psychiatrica Scandinavica 87 (1993) 456-462
62. Torgersen S. Genetic factors in anxiety disorder. Arch Gen Psychiatry 40 (1983) 1085-1089
63. Valleni-Basile L.A., Garrison C.Z., Jackson K.L., Waller J.L., McKeown R.E., Addy C.L., and Cuffe S.P. Frequency of obsessive-compulsive disorder in a community sample of young adolescents. J Am Acad Child Adolesc Psychiatry 33 (1994) 782-791
64. Weissman M.M., Bland R.C., Canino G.J., Greenwald S., Hwu H.G., Lee C.K., et al. The cross national epidemiology of obsessive compulsive disorder. J Clin Psychiatry 55 (1994) 5-10
65. Weissman M.M., Leckman J.F., Merikangas K.R., Gammon G.D., and Prusoff B.A. Depression and anxiety disorders in parents and children: Results from the Yale family study. Arch Gen Psychiatry 41 (1984) 845-852