Combined trichloroacetic acid peel and topical ascorbic acid versus trichloroacetic acid peel alone in the treatment of melasma: A comparative study

Journal of Cosmetic Dermatology

Volumn 6, Issue 2, 2007, Pages 89-94

  Soliman, Mohsen Mohamed ^a   Ramadan, Shahira Abdel Rahman ^a   Bassiouny, Dalia Ahmed ^a,b   Abdelmalek, Marwa ^a  

^a Cairo University   (Egypt)

^b NONE   (Egypt)

Author keywords

Ascorbic acid; Hydroquinone; Melasma; Tretinoin; Trichloroacetic acid

Indexed keywords

ANTIBIOTIC AGENT; ASCORBIC ACID; CORTICOSTEROID; HYDROQUINONE; RETINOIC ACID; TRICHLOROACETIC ACID;

ACNE; ADULT; ARTICLE; CHLOASMA; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FEMALE; FOLLOW UP; HUMAN; MONOTHERAPY; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; PRIORITY JOURNAL; SCORING SYSTEM; SKIN EXAMINATION; TREATMENT DURATION; TREATMENT OUTCOME;

ADMINISTRATION, CUTANEOUS; ADULT; ASCORBIC ACID; CHEMEXFOLIATION; DERMATOLOGIC AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FACIAL DERMATOSES; FEMALE; HUMANS; MELANOSIS; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TRETINOIN; TRICHLOROACETIC ACID;

EID: 34249797605     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/j.1473-2165.2007.00302.x     Document Type: Article

References (21)

1. Kroumpouzos G, Cohen LM. Dermatoses of pregnancy. J Am Acad Dermatol 2001; 45: 1-19.
2. Pathak MA, Fitzpatrick TB, Kraus EW. Usefulness of retinoic acid in the treatment of melasma. J Am Acad Dermatol 1986; 15: 894-9.
3. Grimes PE. Melasma. Etiologic and therapeutic considerations. Arch Dermatol 1995; 131: 1453-7.
4. Kauh YC, Zachian TF, Melasma. Adv Exp Med Biol 1999; 455: 491-9.
5. Cayce KA, McMichael AJ, Feldman SR. Hyperpigmenation: An overview of the common afflictions. Dermatol Nurs 2004; 16 (401-406): 413-6.
6. Grimes PE, Gombrell-Hunt S. Considerations for cosmetic surgery in the black population. Clin Plast Surg 1993; 20: 27-34.
7. Kameyama K, Sakai C, Kondoh S et al. Inhibitory effect of magnesium l-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo. J Am Acad Dematol 1996; 34: 29-33.
8. Dreher F, Maibach H. Protective effects of topical antioxidants in humans. Curr Probl Dermatol 2001; 29: 157-64.
9. Darr D, Combs S, Dunston S et al. Topical vitamin C protects porcine skin from ultraviolet radiation induced damage. Br J Dermatol 1992; 127: 247-51.
10. Catani MV, Rossi A, Costanzo A et al. Induction of gene expression via activator protein 1 in ascorbate protection against UV-induced damage. Biochem J 2001; 15: 77-85.
11. Savini I, Catani MV, Rossi A, Duranti G, Melino G, Avigliano L. Characterization of keratinocyte differentiation induced by ascorbic acid: Protein kinase C involvement and vitamin C homeostasis. J Invest Dermatol 2002; 118: 372-9.
12. Kimbrough-Green CK, Griffiths CEM, Finkel LJ et al. Topical retinoic acid (tretinoin) for melasma in Black patients. A vehicle-controlled clinical trial. Arch Dermatol 1994; 130: 727-33.
13. Mosher DB, Fitzpatrick TB, Ortonne JP, Hori Y. Hypomelanoses and hypermelanoses. In: IM Freedberg, AZ Eisen, K Wolff, KF Austen, LA Goldsmith, SI Katz, TB Fitzpatrick, eds. Dermatology in General Medicine, 5th edn. New York: McGraw-Hill ; 1999: 996-7.
14. Rubin MG. Trichloroacetic acid peels. In: MG Rubin, ed. Manual of Chemical Peels, Superficial and Medium Depth, 1st edn. Philadelphia: JB Lippincott ; 1995: 110-20.
15. Nanda S, Grover C, Reddy BSN. Efficacy of hydroquinone (2%) versus tretinoin (0.025%) as adjunct topical agents for chemical peeling in patients of melasma. Dermatol Surg 2004; 30: 385-9.
16. Chun EY, Lee JB, Lee KH. Focal trichloroacetic acid peel method for benign pigmented lesions in dark-skinned patients. Dermatol Surg 2004; 30: 512-6.
17. Lee GY, Kim HJ, Whang KK. The effect of combination treatment of the recalcitrant pigmentary disorders with pigmented laser and chemical peeling. Dermatol Surg 2002; 28: 1120-3.
18. Kang WH, Yoon KH, Lee E-S et al. Melasma: Histopathological characteristics in 56 Korean patients. Br J Dermatol 2002; 146: 228-37.
19. Espinal-Perez LE, Moncado B, Castanedo-Cazares JP. A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma. Int J Dermatol 2004; 43: 604-7.
20. Huh C-H, Seo K, Park J-Y, Lim JG, Eun HC, Park KC. A randomized, double-blind, placebo-controlled trial of vitamin C iontophoresis in melasma. Dermatology 2003; 206: 316-20.
21. Guevara IL, Pandya AG. Safety and efficacy of 4% hydroquinone combined with 10% glycolic acid, antioxidants, and sunscreen in the treatment of melasma. Int J Dermatol 2003; 42: 966-72.