Characterization of keratinocyte differentiation induced by ascorbic acid: Protein kinase C involvement and vitamin C homeostasis

Journal of Investigative Dermatology

Volumn 118, Issue 2, 2002, Pages 372-379

  Savini, Isabella ^a   Catani, Maria Valeria ^a   Rossi, Antonello ^a   Duranti, Guglielmo ^a   Melino, Gerry ^a   Avigliano, Luciana ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Activating protein 1 (AP 1); Dehydroascorbate; Glutathione; hSVCT1; hSVCT2

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CALCIUM; DEHYDROASCORBIC ACID; DNA; GLUTATHIONE; PROTEIN KINASE C;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; MARKER GENE; NEWBORN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN FUNCTION; TRANSDUCER;

EID: 0036174692     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01624.x     Document Type: Article

References (46)

1. Determination of glutathione and glutathione disulfide in biological samples
2. Multistep production of bioengineered skin substitutes: Sequential modulation of culture conditions
3. Serum and extracellular calcium modulate induction of cytochrome P-450IA1 in human keratinocytes
4. Normal keratinization in a spontaneously immortalised aneuploid human keratinocyte cell line
5. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
6. Transplasma membrane redox system in HL-60 cells is modulated during TPA-induced differentiation
7. Induction of gene expression via AP-1 in the ascorbate protection against UV-induced damage
8. Selective changes in protein kinase C (PK-C) isoform expression in rabbit corneal epithelium during wound healing. Inhibition of corneal epithelial repair by PK-C alpha antisense
9. The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation
10. Ascorbic acid-induced chondrocyte terminal differentiation: The role of the extracellular matrix and 1,25-dihydroxyvitamin D
11. The role of ascorbic acid in mesenchymal differentiation
12. HepG2/erythroid/brain type glucose transporter (GLUT1) is highly expressed in human epidermis: Keratinocyte differentiation affects GLUT1 levels in reconstituted epidermis
13. Protein kinase C signaling and oxidative stress
14. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
15. Regulation of antioxidant enzymes
16. Calcium regulation of growth and differentiation of mouse epidermal cells in culture
17. Cornified cell envelope
18. Thioredoxin and thioredoxin reductase
19. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain
20. AP-1 function and regulation
21. The distribution of ascorbic acid and dehydroascorbic acid during tissue regeneration in wounded dorsal skin of guinea pigs
22. The proximal promoter of the transglutaminase 3 gene
23. Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element
24. S-nitrosylation regulates apoptosis
25. Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation
26. Bricks and mortar of the epidermal barrier
27. Characterization of osteoblastic differentiation of stromal cell line ST 2 that is induced by ascorbic acid
28. The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C
29. Human placental sodium-dependent vitamin C transporter (SVCT2): Molecular cloning and transport function
30. The keratinocyte
31. Effect of AP-1 transcription factors on the regulation of transcription in normal human epidermal keratinocytes
32. Nitric oxide inhibits cornified envelope formation in human keratinocytes by inactivating transglutaminases and activating protein 1
33. Differentiation of mouse keratinocytes is accompanied by PK-C-dependent changes in AP-1 proteins
34. Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expression
35. AA recycling in N-myc amplified human neuroblastoma cells
36. AA maintenance in HaCaT cells prevents radical formation and apoptosis by UV-B
37. DehydroAA uptake in a human keratinocyte cell line (HaCaT) is glutathione-independent
38. Rapid detection of octamer-binding proteins with ‘mini-extracts’, prepared from a small number of cells
39. Protein composition of cornified cell envelopes of epidermal keratinocytes
40. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
41. A family of mammalian Na+-dependent L-AA transporters
42. Resolution of the facilitated transport of dehydroAA from its intracellular accumulation as AA
43. Human Na (+)-dependent vitamin C transporter 1 (hSVCT1): Primary structure, functional characteristics and evidence for a non-functional splice variant
44. Differential expression of the fos and jun family members c-fos, fosB, fra-1, fra-2, c-jun, junB and junD during human epidermal keratinocyte differentiation
45. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: Requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence
46. Transcriptional regulation of human transglutaminase1 gene by signaling systems of protein kinase C, RAR/RXR and Jun/Fos in keratinocytes