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Volumn , Issue 8, 2007, Pages 1251-1254

Chromatography-free suzuki reactions using a Polymer-Assisted Solution-Phase (PASP) approach

Author keywords

Encapsulated palladium catalyst; Microwave heating; Parallel synthesis; Polymer supported reagents; Suzuki cross coupling

Indexed keywords

PALLADIUM; POLYMER; REAGENT;

EID: 34249790573     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-977457     Document Type: Article
Times cited : (13)

References (37)
  • 1
    • 27144488370 scopus 로고    scopus 로고
    • Recent reviews include: a
    • Recent reviews include: (a) Suzuki, A. Chem. Commun. 2005, 38, 4759.
    • (2005) Chem. Commun , vol.38 , pp. 4759
    • Suzuki, A.1
  • 2
    • 11244296859 scopus 로고    scopus 로고
    • 2nd ed, de Meijere, A, Diederich, F, Eds, Wiley-VCH: Weinheim
    • (b) Miyaura, N. In Metal-Catalyzed Cross-Coupling Reactions, 2nd ed., Vol. 1: de Meijere, A.; Diederich, F., Eds.; Wiley-VCH: Weinheim, 2004, 41-123.
    • (2004) Metal-Catalyzed Cross-Coupling Reactions , vol.1 , pp. 41-123
    • Miyaura, N.1
  • 16
    • 34249816897 scopus 로고    scopus 로고
    • FibreCat 1001 is available from Johnson Matthey.
    • (e) FibreCat 1001 is available from Johnson Matthey.
  • 17
    • 34249815934 scopus 로고    scopus 로고
    • 4 is available from Biotage AB.
    • 4 is available from Biotage AB.
  • 20
    • 34249794665 scopus 로고    scopus 로고
    • 2EnCat™ is available from Sigma Aldrich.
    • 2EnCat™ is available from Sigma Aldrich.
  • 21
    • 34249805210 scopus 로고    scopus 로고
    • 2EnCat™ (5 mol%, based on palladium content). The reaction mixture was stirred at 85 °C for 18 h.
    • 2EnCat™ (5 mol%, based on palladium content). The reaction mixture was stirred at 85 °C for 18 h.
  • 22
    • 34249793782 scopus 로고    scopus 로고
    • MP-Carbonate was obtained from Sigma-Aldrich with a reported loading of 2.5-3.5 mmol/g.
    • MP-Carbonate was obtained from Sigma-Aldrich with a reported loading of 2.5-3.5 mmol/g.
  • 26
    • 34249826428 scopus 로고    scopus 로고
    • N,N-Diethanol-aminomethyl polystyrene (PS-DEAM) was obtained from Biotage AB.
    • (c) N,N-Diethanol-aminomethyl polystyrene (PS-DEAM) was obtained from Biotage AB.
  • 27
    • 34249814124 scopus 로고    scopus 로고
    • Although the water present could be removed using anhydrous molecular sieves, a more reliable and pragmatic procedure proved to be co-evaporation prior to redissolution in DMF
    • Although the water present could be removed using anhydrous molecular sieves, a more reliable and pragmatic procedure proved to be co-evaporation prior to redissolution in DMF.
  • 33
    • 34249823447 scopus 로고    scopus 로고
    • Microwave reactions were performed using an Emrys® synthesiser available from Biotage AB
    • (f) Microwave reactions were performed using an Emrys® synthesiser available from Biotage AB.
  • 34
    • 34249809214 scopus 로고    scopus 로고
    • Microwave temperatures were measured externally to the reactor vial using the IR sensor fitted to the Emrys® synthesiser. It is extremely unlikely that these values accurately reflect the significantly higher localised temperatures attained at the catalyst metal surface under microwave irradiation
    • Microwave temperatures were measured externally to the reactor vial using the IR sensor fitted to the Emrys® synthesiser. It is extremely unlikely that these values accurately reflect the significantly higher localised temperatures attained at the catalyst metal surface under microwave irradiation.
  • 35
    • 34249786664 scopus 로고    scopus 로고
    • Palladium residue levels were determined using inductively coupled plasma optical emission spectroscopy performed on 4′-methoxy-4- methylbiphenyl(3) for both thermal and microwave reactions and indicated residual palladium levels in 3 corresponding to Pd leaching from Pd(OAc)2EnCat™ to be 2.1% and 1.7, respectively
    • 2EnCat™ to be 2.1% and 1.7%, respectively.
  • 36
    • 34249794074 scopus 로고    scopus 로고
    • High-speed vortexing was performed using a DESYRE®-MIX vortexer, available from Zinsser Analytic GmbH
    • High-speed vortexing was performed using a DESYRE®-MIX vortexer, available from Zinsser Analytic GmbH.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.