Metformin prolongs the postprandial fall in plasma ghrelin concentrations in type 2 diabetes

Diabetes/Metabolism Research and Reviews

Volumn 23, Issue 4, 2007, Pages 299-303

  English, P J ^a   Ashcroft, A ^b   Patterson, M ^c   Dovey, T M ^b   Halford, J C G ^b   Harrison, J ^a   Eccleston, D ^a   Bloom, S R ^c   Ghatei, M A ^c   Wilding, J P H ^a  

^a UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Diabetes; Ghrelin; Metformin; Obesity; Peptide YY

Indexed keywords

GHRELIN; GLUCOSE; INSULIN; LEPTIN; METFORMIN; PEPTIDE YY;

ADULT; AGE DISTRIBUTION; ANTHROPOMETRY; ARTICLE; CALORIC INTAKE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC DIET; DIET RESTRICTION; DRUG MECHANISM; ENERGY BALANCE; ENERGY EXPENDITURE; FEMALE; FOOD INTAKE; GENDER; HUMAN; HUNGER; MALE; METABOLIC RATE; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THERMOGENESIS; WEIGHT REDUCTION;

ADULT; APPETITE; DIABETES MELLITUS, TYPE 2; ENERGY METABOLISM; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; MIDDLE AGED; OSMOLAR CONCENTRATION; PEPTIDE HORMONES; PEPTIDE YY; POSTPRANDIAL PERIOD; SATIETY RESPONSE; THERMOGENESIS;

EID: 34249786895     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.681     Document Type: Article

References (19)

1. Wing RR, Marcus MD, Epstein LH, Salata R. Type II diabetic subjects lose less weight than their overweight nondiabetic spouses. Diabetes Care 1987; 10(5): 563-566.
2. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352(9131): 854-865.
3. Pasquali R, Gambineri A, Biscotti D, et al. Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome. J Clin Endocrinol Metab 2000; 85(8): 2767-2774.
4. Makimattila S, Nikkila K, Yki-Jarvinen H. Causes of weight gain during insulin therapy with and without metformin in patients with Type II diabetes mellitus. Diabetologia 1999; 42(4): 406-412.
5. Chong PK, Jung RT, Rennie MJ, Scrimgeour CM. Energy expenditure in type 2 diabetic patients on metformin and sulphonylurea therapy. Diabet Med 1995; 12(5): 401-408.
6. Leslie P, Jung RT, Isles TE, Baty J. Energy expenditure in non-insulin dependent diabetic subjects on metformin or sulphonylurea therapy. Clin Sci (Colch) 1987; 73(1): 41-45.
7. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002; 418(6898): 650-654.
8. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985; 89(5): 1070-1077.
9. Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003; 349(10): 941-948.
10. Wren AM, Small CJ, Abbott CR, et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001; 50(11): 2540-2547.
11. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001; 86(12): 5992.
12. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001; 50(8): 1714-1719.
13. Shiiya T, Nakazato M, Mizuta M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002; 87(1): 240-244.
14. Ostergard T, Hansen TK, Nyholm B, et al. Circulating ghrelin concentrations are reduced in healthy offspring of Type 2 diabetic subjects, and are increased in women independent of a family history of Type 2 diabetes. Diabetologia 2003; 46(1): 134-136.
15. Poykko SM, Kellokoski E, Horkko S, Kauma H, Kesaniemi YA, Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 2003; 52(10): 2546-2553.
16. Ben-Porat M, Sideman S, Bursztein S. Energy metabolism rate equation for fasting and postabsorptive subjects. Am J Physiol 1983; 244(6): R764-R769.
17. English PJ, Ghatei MA, Malik IA, Bloom SR, Wilding JP. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 2002; 87(6): 2984-2987.
18. Williams DL, Grill HJ, Cummings DE, Kaplan JM. Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology 2003; 144(12): 5184-5187.
19. Guler S, Cakir B, Demirbas B, Gursoy G, Serter R, Aral Y. Leptin concentrations are related to glycaemic control, but do not change with short-term oral antidiabetic therapy in female patients with type 2 diabetes mellitus. Diabetes Obes Metab 2000; 2(5): 313-316.