Mcm2 predicts recurrence hazard in stage Ta/T1 bladder cancer more accurately than CK20, Ki67 and histological grade

British Journal of Cancer

Volumn 96, Issue 11, 2007, Pages 1711-1715

  Burger, M ^a,b   Denzinger, S ^a,b   Hartmann, A ^b   Wieland, W F ^a,b   Stoehr, R ^a,b   Obermann, E C ^b  

^a Department of Urology ^*  (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Bladder cancer; CK20; Ki67; Mcm2

Indexed keywords

CYTOKERATIN 20; KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 2; TUMOR MARKER;

ARTICLE; BLADDER CARCINOMA; CANCER GRADING; CANCER RECURRENCE; CANCER STAGING; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE MARKER; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TISSUE MICROARRAY; TUMOR CELL; UNIVARIATE ANALYSIS;

CARCINOMA; CELL CYCLE PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; KERATIN-20; KI-67 ANTIGEN; MOLECULAR DIAGNOSTIC TECHNIQUES; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NUCLEAR PROTEINS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 34249780379     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603784     Document Type: Article

References (21)

1. Brausi M, Collette L, Kurth K, van der Meijden AP, Oosterlinck W, Witjes JA, Newling D, Bouffioux C, Sylvester RJ, EORTC Genito-Urinary Tract Cancer Collaborative Group (2002) Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: a combined analysis of seven EORTC studies. Eur Urol 41(5): 523-531
2. Harnden P, Mahmood N, Southgate J (1999) Expression of cytokeratin 20 redefines urothelial papillomas of the bladder. Lancet 353(9157): 974-977
3. Hashimoto K, Araki K, Osaki M, Nakamura H, Tomita K, Shimizu E, Ito H (2004) MCM2 and Ki-67 expression in human lung adenocarcinoma: prognostic implications. Pathobiology 71(4): 193-200
4. Klopocki E, Kristiansen G, Wild PJ, Klaman I, Castanos-Velez E, Singer G, Stohr R, Simon R, Sauter G, Leibiger H, Essers L, Weber B, Hermann K, Rosenthal A, Hartmann A, Dahl E (2004) Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. Int J Oncol 25(3): 641-649
5. Korkolopoulou P, Givalos N, Saetta A, Goudopoulou A, Gakiopoulou H, Thymara I, Thomas-Tsagli E, Patsouris E (2005) Minichromosome maintenance proteins 2 and 5 expression in muscle-invasive urothelial cancer: a multivariate survival study including proliferation markers and cell cycle regulators. Hum Pathol 36(8): 899-907
6. Krüger S, Thorns C, Stocker W, Müller-Kunert E, Bohle A, Feller AC (2003) Prognostic value of Mcm2 immunoreactivity in stage T1 transitional cell carcinoma of the bladder. Eur Urol 43: 138-145
7. Lopez-Beltran A, Luque RJ, Alvarez-Kindelan J, Quintero A, Merlo F, Requena MJ, Montironi R (2004) Prognostic factors in survival of patients with stage Ta and T1 bladder urothelial tumors: the role of G1-S modulators (p53, p21Waf1, p27Kip1, cyclin D1, and cyclin D3), proliferation index, and clinicopathologic parameters. Am J Clin Pathol 122(3): 444-452
8. Maiorano D, Lutzmann M, Mechali M (2006) MCM proteins and DNA replication. Curr Opin Cell Biol 18: 130-136
9. Meng MV, Grossfeld GD, Williams GH, Dilworth S, Stoeber K, Mulley TW, Weinberg V, Carroll PR, Tlsty TD (2001) Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer. Clin Cancer Res 7(9): 2712-2718
10. Millan-Rodriguez F, Chechile-Toniolo G, Salvador-Bayarri J, Palou J, Vicente-Rodriguez J (2000) Multivariate analysis of the prognostic factors of primary superficial bladder cancer. J Urol 163: 73-78
11. Mostofi FK, Sobin LH, Torloni H (1973) Histological Typing of Urinary Bladder Tumours. World Health Organization: Geneva
12. Obermann EC, Went P, Zimpfer A, Tzankov A, Wild PJ, Stoehr R, Pileri SA, Dirnhofer S (2005) Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis. BMC Cancer 20: 5-162
13. Oosterlinck W, Lobel B, Jakse G, Malmstrom PU, Stockle M, Sternberg C. (2002) European Association of Urology (EAU) Working Group on Oncological Urology. Guidelines on bladder cancer. Eur Urol 41: 105-112
14. Rodins K, Cheale M, Coleman N, Fox SB (2002) Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility. Clin Cancer Res 8: 1075-1081
15. Stoeber K, Halsall I, Freeman A, Swinn R, Doble A, Morris L, Coleman N, Bullock N, Laskey RA, Hales CN, Williams GH (1999) Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine. Lancet 354(9189): 1524-1525
16. Tachibana KE, Gonzalez MA, Coleman N (2005) Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology. J Pathol 205: 123-129
17. Tosoni I, Wagner U, Sauter G, Egloff M, Knonagel H, Alund G, Bannwart F, Mihatsch MJ, Gasser TC, Maurer R (2000) Clinical significance of interobserver differences in the staging and grading of superficial bladder cancer. Br J Urol 85: 48-53
18. UICC (2002) TNM Classification of Malignant Tumors. 6th edn. Wiley & Sons: New York
19. van Oers J, Wild PJ, Burger M, Denzinger S, Stoehr R, Rosskopf E, Hofstaedter F, Steyerberg E, Klinkhammer-Schalke M, Zwarthoff E, van der Kwast T, Hartmann A (2007) FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. Eur Urol. doi:10.1016/j.eururo.2007.01.009
20. van Rhijn BW, Vis AN, van der Kwast TH, Kirkels WJ, Radvanyi F, Ooms EC, Chopin DK, Boeve ER, Jobsis AC, Zwarthoff EC (2003) Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome. J Clin Oncol 21(10): 1912-1921
21. Verheijen R, Kuijpers HJ, van Driel R, Beck Jl, van Dierendonck JH, Brakenhoff GJ, Ramaekers FC (1989) Ki67 detects a nuclear matrixassociated proliferation related antigen. II. Localisation in mitotic cells and association with chromosomes. J Cell Sci 92: 531-540