Transmeningeal delivery of GABA to control neocortical seizures in rats

Epilepsy Research

Volumn 75, Issue 1, 2007, Pages 10-17

  John, Jenine E ^a   Baptiste, Shirn L ^a   Sheffield, Lynette G ^b   von Gizycki, Hans ^c   Kuzniecky, Ruben I ^a   Devinsky, Orrin ^a   Ludvig, Nandor ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SUNY Downstate Medical Center   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Acetylcholine; Dura mater; EEG; GABA; Neocortical seizures

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DOSE INCREASE; DRUG EFFECT; DURA MATER; ELECTRODE; ELECTROENCEPHALOGRAM; FOCAL EPILEPSY; IMPLANTATION; MALE; MENINX; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG INTERACTIONS; ELECTROENCEPHALOGRAPHY; FOURIER ANALYSIS; GAMMA-AMINOBUTYRIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; NEOCORTEX; RATS; RATS, LONG-EVANS; SEIZURES;

EID: 34249779513     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2007.03.014     Document Type: Article

References (37)

1. Anschel D.J., Ortega E.L., Kraus A.C., and Fisher R.S. Focally injected adenosine prevents seizures in the rat. Exp. Neurol. 190 (2004) 544-547
2. Bacci A., Rudolph U., Huguenard J.R., and Prince D.A. Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses. J. Neurosci. 23 (2003) 9664-9674
3. Bowery N.G., and Smart T.G. GABA and glycine as neurotransmitters: a brief history. Br. J. Pharmacol. 147 (2006) S109-S119
4. Brailowsky S., Silva-Barrat C., Menini C., Riche D., and Naquet R. Effects of localized, chronic GABA infusions into different cortical areas of the photosensitive baboon, Papio papio. Electroencephalogr. Clin. Neurophysiol. 72 (1989) 147-156
5. Brailowsky S., Kunimoto M., Silva-Barrat C., Menini C., and Naquest R. Electroencephalographic study of the GABA-withdrawal syndrome in rats. Epilepsia 31 (1990) 369-377
6. Calcagnotto M.E., Paredes M.F., Tihan T., Barbaro N.M., and Baraban S.C. Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia. J. Neurosci. 25 (2005) 9649-9657
7. A receptors. Epilepsy Res. 47 (2002) 257-271
8. Devinsky O. Patients with refractory seizures. N. Engl. J. Med. 340 (1999) 1565-1570
9. Eder H.G., Jones D.B., and Fisher R.S. Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats. Epilepsia 38 (1997) 516-521
10. Fukuda H., Brailowsky S., Menini C., Silva-Barrat C., Riche D., and Naquet R. Anticonvulsant effect of intracortical, chronic infusion of GABA in kindled rats: focal seizures upon withdrawal. Exp. Neurol. 98 (1987) 120-129
11. Gernert M., Thompson K.W., Loscher W., and Tobin A.J. Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats. Exp. Neurol. 176 (2002) 183-192
12. Gupta A., Wang Y., and Markram H. Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science 287 (2000) 273-278
13. Krantis A. The involvement of GABA-transaminase in the blood-brain barrier to radiolabelled GABA. Acta Neuropathol. (Berl). 64 (1984) 61-67
14. Litt B., Esteller R., Echauz J., D'Alessanro M., Shor R., Henry T., Pannell P., Epstein C., Bakay R., Dichter M., and Vachtsevanos G. Epileptic seizures may begin hours in advance of clinical onset: a report of five patients. Neuron 30 (2001) 51-64
15. Ludvig N. Drug deliveries into the microenvironment of electrophysiologically monitored neurons in the brain of behaving rats and monkeys. In: Chapin J.K., and Moxon K.A. (Eds). Neural Prostheses for Restoration of Sensory and Motor Function (2000), CRC Press, Boca Raton, FL 263-283
16. Ludvig N., and Tang H.M. Cellular electrophysiological changes in the hippocampus of freely behaving rats during local microdialysis with epileptogenic concentration of NMDA. Brain Res. Bull. 51 (2000) 233-240
17. Ludvig, N., Kovacs, L., 2002. Hybrid neuroprosthesis for the treatment of brain disorders. US Patent 6,497,699. www.uspto.gov
18. Ludvig N., Kovacs L., Medveczky G., Kuzniecky R.I., and Devinsky O. Toward the development of a subdural hybrid neuroprosthesis for the treatment of intractable focal epilepsy. Epilepsia 46 Suppl. 8 (2005) 270
19. Ludvig N., Kuzniecky R.I., Baptiste S.L., John J.E., von Gizycki H., Doyle W.K., and Devinsky O. Epidural pentobarbital delivery can prevent locally induced neocortical seizures in rats: the prospect of transmeningeal pharmacotherapy for intractable focal epilepsy. Epilepsia 47 (2006) 1792-1802
20. MacDermott A.B., Role L.W., and Siegelbaum S.A. Presynaptic ionotropic receptors and the control of transmitter release. Annu. Rev. Neurosci. 22 (1999) 443-485
21. Motulsky H. Intuitive Biostatistics (1995), Oxford University Press, Oxford
22. Nilsen K.E., and Cock H.R. Focal treatment for refractory epilepsy: hope for the future?. Brain Res. Rev. 44 (2004) 141-153
23. Olsen R.W., and Avioli M. GABA and epileptogenesis. Epilepsia 38 (1997) 399-407
24. In: Oxbury J.M., Polkey C.E., and Duchowny M. (Eds). Intractable Focal Epilepsy (2000), W.B. Saunders, New York
25. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 4th ed. (1998), Academic Press, New York
26. Ribak C.E., Harris A.B., Vaughn J.E., and Roberts E. Inhibitory, GABAergic nerve terminals decrease at sites of focal epilepsy. Science 205 (1979) 211-214
27. Rogawski M.A. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 (2006) 273-294
28. Sherwin A.L. Neuroactive amino acids in focally epileptic human brain: a review. Neurochem. Res. 24 (1999) 1387-1395
29. Shorvon S. Handbook of Epilepsy Treatment. 2nd ed. (2005), Blackwell Publishing, Oxford
30. Silva A.V., Sanabria E.R., Cavalheiro E.A., and Spreafico R. Alterations of the neocortical GABAergic system in the pilocarpine model of temporal lobe epilepsy: neuronal damage and immunocytochemical changes in chronic epileptic rats. Brain Res. Bull. 58 (2002) 417-421
31. Somogyi P., Tamas G., Lujan R., and Buhl E.H. Salient features of synaptic organization in the cerebral cortex. Brain Res. Rev. 26 (1998) 113-135
32. A receptors. TiPS 16 (1995) 162-168
33. Stein A.G., Eder H.G., Blum D.E., Drachev A., and Fisher R.S. An automated drug delivery system for focal epilepsy. Epilepsy Res. 39 (2000) 103-114
34. Thompson K.W. Genetically engineered cells with regulatable GABA production can affect afterdoscharges and behavioral seizures after transplantation into the dentate gyrus. Neuroscience 133 (2005) 1029-1037
35. Treiman D.M. GABAergic mechanisms in epilepsy. Epilepsia 42 Suppl. 3 (2001) 8-12
36. Turner D.A., Nicolelis M.A.L., and Landingham K. Pre-ictal seizure detection and demand treatment strategies for epilepsy. In: Turner D.A. (Ed). Modern Neurosurgery. Clinical Translation of Neuroscience Advances (2005), CRC Press, Boca Raton, FL 105-118
37. Yokoi I., Kabuto H., and Mori A. Effects of GABAmimetics on electrocorticographic spike discharges induced by guanidineoethanesulfonic acid (amidino-taurine) in the rat. Neurochem. Res. 18 (1993) 533-538