Decreased Src tyrosine kinase activity inhibits malignant human ovarian cancer tumor growth in a nude mouse model

Clinical Cancer Research

Volumn 5, Issue 8, 1999, Pages 2164-2170

  Wiener, Jon R ^a   Nakano, Kayo ^a   Kruzelock, Russell P ^a,b   Bucana, Corazon D ^a   Bast Jr , Robert C ^a   Gallick, Gary E ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER MODEL; ENZYME ACTIVITY; EXPRESSION VECTOR; FEMALE; GENETIC TRANSFECTION; GROWTH REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN TARGETING;

ANIMALS; ANTIGENS, CD31; BLOTTING, NORTHERN; CELL DIVISION; DISEASE MODELS, ANIMAL; ENDOTHELIAL GROWTH FACTORS; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOKINES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; OLIGONUCLEOTIDES, ANTISENSE; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032812095     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Bast, R. C., Jr., Xu, F., Yu, Y., Fang, X. J., Wiener, J., and Mills, G. B. Overview: the molecular biology of ovarian cancer. In: F. Sharp, T. Blackett, J. Berek, and R. Bast (eds.), Ovarian Cancer, Vol. 5, pp. 87-97. Oxford, United Kingdom: Isis Medical Media Publishers, 1998.
2. c-src family of protein-tyrosine kinases: structure, regulation, and function. Crit. Rev. Oncogen., 3: 401-446, 1992.
3. Brown, M. T., and Cooper, J. A. Regulation, substrates and functions of src. Biochim. Biophys. Acta, 1287: 121-149, 1996.
4. Erpel, T., and Courtneidge, S. A. Src family protein tyrosine kinases and cellular signal transduction pathways. Curr. Opin. Cell Biol., 7: 176-182, 1995.
5. Parsons, J. T., and Parsons, S. J. Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. Curr. Opin. Cell Biol., 9: 187-192, 1997.
6. c-src protein kinase activity in human colon carcinoma. Proc. Natl. Acad. Sci. USA, 84: 2251-2255, 1987.
7. c-src protein kinase is an early event in colonic carcinogenesis. Proc. Natl. Acad. Sci. USA, 87: 558-562, 1990.
8. Muthuswamy, S. K., Siegel, P. M., Dankort, D. L., Webster, M. A., and Muller, W. J. Mammary tumors expressing the neu proto-oncogene possess elevated c-src tyrosine kinase activity. Mol. Cell. Biol., 14: 735-743, 1994.
9. Verbeek, B. S., Vroom, T. M., Adriaansen-Slot, S. S., Ottenhoff-Kalff, A. E., Geertzema, J. G. N., Hennipman, A., and Rijksen, G. c-src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis. J. Pathol., 180: 383-388, 1996.
10. Lutz, M. P., Silke Eber, I. B., Flossmann-Kast, B. B. M., Vogelmann, R., Luhrs, H., Friess, H., Buchler, M. W., and Adler, G. Overexpression and activation of the tyrosine kinase src in human pancreatic carcinoma. Biochem. Biophys. Res. Commun., 243: 503-508, 1998.
11. Staley, C. A., Parikh, N. U., and Gallick, G. E. Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-src. Cell Growth Differ., 8: 269-274, 1997.
12. Yu, D., Matin, A., Xia, W., Sorgi, F., Huang, L., and Hung, M-C. Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu. Oncogene, 11: 1383-1388, 1995.
13. Yoneda, J., Kuniyasu, H., Crispens, M. A., Price, J. A., Bucana, C. D., and Fidler, I. J. Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice. J. Natl. Cancer Inst., 90: 447-454, 1998.
14. c-src. Oncogene, 6: 1983-1989, 1991.
15. Lee, J. H., and Welch, D. R. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res., 57: 2384-2387, 1997.
16. Xu, F. J., Boyer, C. M., Bae, D. S., Wu, S., Greenwald, M., O'Briant, K., Yu, Y. H., Mills, G. B., and Bast, R. C., Jr. The tyrosine kinase activity of the c-erb-B-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-a chain immunotoxin. Int. J. Cancer, 59: 242-247, 1994.
17. c-erbB-2 protein expression. J. Natl. Cancer Inst., 86: 372-378, 1994.
18. Mukhopadhyay, D., Tsiokas, L., Zhou, X.-M., Foster, D., Brugge, J. S., and Sukhatme, V. P. Hypoxic induction of human vascular endothelial growth factor expression through c-src activation. Nature (Lond.), 375: 577-581, 1995.
19. Fleming, R. Y. D., Ellis, L. M., Parikh, N. U., Liu, W., Staley, C. A., and Gallick, G. E. Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase. Surgery, 122: 501-507, 1997.
20. Ellis, L. M., Staley, C. A., Liu, W., Fleming, R. Y. D., Parikh, N. U., Bucana, C. D., and Gallick, G. E. Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src. J. Biol. Chem., 273: 1052-1057, 1998.
21. Nakanishi, Y., Kodama, J., Yoshinouchi, M., Tokumo, K., Kamimura, S., Okuda, H., and Kudo, T. The expression of vascular endothelial growth factor and transforming growth factor-β associates with angiogenesis in epithelial ovarian cancer. Int. J. Gynecol. Pathol., 16: 256-262, 1997.
22. Hartenbach, E. M., Olso, T. A., Goswitz, J. J., Mohanraj, D., Twiggs, L. B., Carson, L. F., and Ramakrishnan, S. Vascular endothelial growth factor (VEGF) expression and survival in human epithelial ovarian carcinomas. Cancer Lett., 121: 169-175, 1997.
23. Vecchi, A., Garlanda, C., Lampugnani, M. G., Resnati, M., Matteucci, C., Stoppacciaro, A., Schnurch, H., Risau, W., Ruco, L., Mantovani, A., and Dejana, E. Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur. J. Cell Biol., 63: 247-254, 1994.
24. Soriano, P., Montgomery, C., Geske, R., and Bradley, A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell, 64: 693-702, 1991.
25. c-src elicits invasive behavior in rat colon epithelial cells. Gastroenterology, 114: 1287-1295, 1998.
26. c-src protein to a transforming protein. Mol. Cell. Biol., 6: 4155-4160, 1986.