Biochemical study on the protective potential of Nardostachys jatamansi extract on lipid profile and lipid metabolizing enzymes in doxorubicin intoxicated rats

Pharmazie

Volumn 62, Issue 5, 2007, Pages 382-387

  Subashini, R ^a   Ragavendran, B ^a   Gnanapragasam, A ^a   Kumar Yogeeta, S ^a   Devaki, T ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CHOLESTEROL; DOXORUBICIN; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NARDOSTACHYS JATAMANSI EXTRACT; PHOSPHOLIPID; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CARDIOTOXICITY; CELL MEMBRANE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG INTOXICATION; DRUG MECHANISM; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE INJURY; HISTOPATHOLOGY; LIPID ANALYSIS; LIPID METABOLISM; MALE; NARDOSTACHYS; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTILIPEMIC AGENTS; CARDIOMYOPATHY, DILATED; DOXORUBICIN; ENZYMES; HEART; HEART DISEASES; LIPID METABOLISM; LIPID PEROXIDATION; LIPIDS; LIPOPROTEINS; MYOCARDIUM; NARDOSTACHYS; PLANT EXTRACTS; RATS;

EID: 34249775171     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2007.5.6678     Document Type: Article

References (52)

1. Abdel-aleem S, El-Merzabani MM, Sayed-Ahmed M, Taylor DA, Lowe JE (1997) Acute and chronic effects of doxorubicin on fatty acid oxidation in isolated cardiac myocytes. J Mol Cell Cardiol 29: 789-797.
2. Ali MS, Ansari KA, Jafry MA, Kabeer H, Diwakar G (2000) Nardostachys jatamansi protects against liver damage induced by thioacetamide in rats. J Ethnopharmacol 71: 359-363.
3. Arai M, Tomaru, Takizaua T, Sekiguchi K, Yokoyama T, Suzuki T, Nagai R (1998) Sarcoplasmic reticulum genes are selectively down-regulated in cardiomyopathy produced by doxorubicin in rabbits. J Mol Cell Cardiol 30: 243-254.
4. Bagchi A, Oshima Y, Hikino H (1991) Neolignans and lignans of Nardostachys jatamansi roots. Planta Med 57: 96-97.
5. Bier M (1955) Enzymes of lipid metabolism-lipases and esterases. Meth Enzymol 1: 631-638.
6. Bordoni A, Baigi PL, Hrelia S (1999) The impairment of essential fatty acid metabolism is a key factor in doxorubicin-induced damage in cultured rat cardiomyocytes. Biochim Biophys Acta 1440: 100-106.
7. Burstein M, Scholnick HR (1972) Precipitation of chylomicron and very low density lipoprotein from human serum with sodium lauryl sulphate. Life Sci 11: 77-84.
8. Chatterjee A, Basak B, Saha M, Dutta U, Mukhopadhyay C, Banerji J, Konda Y, Harigaya Y (2000) Structure and stereochemistry of nardostachysin, a new terpenoid ester constituent of the rhizomes of Nardostachys jatamansi. J Nat Prod 63: 1531-1533.
9. Chauhan RS, Nautiyal MC (2005) Commercial viability of cultivation of an endangered medicinal herb Nardostachys jatamansi at three different agroclimatic zones. Current Science 89: 1481-1488.
10. Chein KR, Sherman SC, Mittamcht S, Jr, Faber JL (1980) Microsomal structure and function subsequent to calcium activation of an endogenous phospholipase. Arch Biochem Biophys 205: 614-622.
11. Deepa PR, Varalakshmi P (2005) Beneficial cardio-renovascular effects of a low-molecular-weight heparin-derivative on doxorubicin-induced glycosaminoglycanuria and tissue lipid abnormalities. Toxicology 211: 77-85.
12. Doroshow JH (1983) Effect of anthracycline antibiotics on oxygen radical formation in rat heart. Cancer Res 43: 460-472.
13. Fiske CH, Subbarow Y (1925) The colorimetric determination of phosphorus. J Biol Chem 66: 375-400.
14. Folch J, Lees M, Stanley GHS (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
15. Foster LB, Dunn RT (1973) Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin Chem 19: 338-340.
16. Freedman DS, Gruchow HW, Anderson AJ, Rimm AA, Barboriak JJ (1988) Relation of triglyceride levels of coronary artery disease: The Milwaukee Cardiovascular Data Registry. Am J Epidemiol 127: 1118-1130.
17. Geetha A, Catherine J, Shankar R, Shyamala Devi CS (1990) Lipids and lipoprotein profile in doxorubicin treated rats: influence of a - tocopherol administration. Indian J Exp Biol 28: 1071-1074.
18. Green AR, Hainsworth AH, Jackson DM (2000) GABA potentiation: a logical pharmacological approach for the treatment of acute ischemic stroke. Neuropharmacology 39: 1483-1494.
19. Grundy SM (1986) Cholesterol and coronary heart disease. A new era. JAMA, 256: 2849-2858.
20. Heindel JJ, Orei L, Jenarenaud B (1975) In International Encyclopaedia of Pharmacology and Therapeutics. Pharmacology of Lipid Transport and Atherosclerotic Processes, Vol. 1, Ed. By Masro, S., Pergamon Press. Oxford, pp. 175-373.
21. Hong YM, Kim HS, Yoon H (2002) Serum lipid and fatty acid profiles in doxorubicin-treated rats after administration of L-carnitine. Pediatr Res 51: 249-255.
22. Horenstein MS, Heide RSV, L'Ecuyer TJ (2000) Molecular basis of anfhracycline-induced cardiotoxicity and its prevention. Mol Genet Metab 72: 436-444.
23. Hron WT, Menahan LA (1981) A sensitive method for the determination of free fatty acids in plasma. J Lipid Res 122: 377-381.
24. Iliskovic, Singal PK (1997) Lipid lowering: an important factor in preventing doxorubicin-induced heart failure. Am J Pathol 150: 727-734.
25. Katz AM, Messinco FC (1981) Lipid membrane interactions and the pathogenesis of ischemic damage in the myocardium. Cir Res 48: 1-16.
26. Kirmukog AG, Aizikov MI, Rasulova SA, Sidiakin GP, Sham'ianov ID, Malikov VM (1991) The angioprotector and hypolipemic activity of leukomizin in experimental atherosclerosis. Farmakol Toksikol 54: 35-37.
27. Kothari HV, Miller BF, Kritchevsky D (1973) Arotic cholesterol esterase : characteristics of normal rat and rabbit enzyme. Biochem Biophys Acta. 296: 446-454.
28. Kothari HV, Bonner MJ, Miller BF (1970) Cholesterol ester hydrolase in homogenates and lysosomal fractions of human aorta. Biochem Biophys Acta 296: 325-331.
29. Koutinos G, Stathopoulos GP, Dontas I, Perrea-Kotsarelis D, Couris E, Karayannacos PE, Deliconstantinos G (2002) The effect of doxorubicin and its analogue mitoxantrone on cardiac muscle and on serum lipids: an experimental study. Anticancer Res 22: 815-820.
30. Kuroda T, Kondo K, Iwasaki T, Ohtani A, Takashima K (1997) Synthesis and hypolipidemic activity of diesters of arylnaphthalene lignan and their hereroaromatic analogs. Chem Pharm Bull (Tokyo) 45: 678-684.
31. Lampidis TJ, Johnson LV, Israel M (1981) Effects of doxorubicin on rat heart cells in culture: increased accumulation and nucleoli fragmentation in cardiac muscle non-muscle cells. J Mol Cell Cardiol 13: 913-924.
32. Legraud A, Guillansseav RJ (1979) Method. Colorimetric simple determination del'actirit, de la lecithin cholesterol acyl transferase (LCAT) plasma fique. Interest on diabetologic. In: Siest G, Glateau MM (Eds.) Biologic Prospective. Masson, Paris, pp. 368-371.
33. Lespine A, Chap H, Perret B (1997) Impaired secretion of heart lipoprotein lipase in cyclophosphamide-rreated rabbit. Biochim Biophys Acta 5: 77-85.
34. Limbaugh EG, Trush M, Gram TE (1983) Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo. Cancer Treat Rep 67: 731-733.
35. Muthu AK, Sethupathy S, Manavalan R, Karar PK (2005) Hypolipidemic effect of methanolic extract of Dolichos biflorus Linn. In high fat diet fed rats. Indian J Exp Biol 43: 522-525.
36. Nagi MN, Mansour MA (2000) Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection. Pharmacol Res 41: 283-289.
37. Neely JR, Morgan HE (1974) Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu Rev Physiol 36: 413-459.
38. Parakh AC, Jung DH (1970) Cholesterol determination with ferric acetateuranyl acetate and sulphuric acid - ferrous sulphate reagents. Anal Chem 42: 1423-1427.
39. Prabhu VM, Karanth KS, Rao A, Vidya PM, Sudhakar K (1994) Effect of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain. Planta Med 60: 114-117.
40. Rao VS, Rao A, Karanth S (2005) Anticonvulsant and neurotoxicity of Nardostachys jatamansi in rats. J Ethnopharmacol 102: 351-356.
41. Roh DD, Kwak P, Nelson D, Kamanna VS, Kirschenbaum MA (1993) Effect of dietary cholesterol on rat glomerular cholesterol esterase. Am J Nephrol 13: 478-482.
42. Salim S, Ahmad M, Zafar KS, Ahmed AS, Islam F (2003) Protective effect of Nardostachys jatamansi in rat cerebral ischemia. Pharmacol Biochem Behv 74: 481-486.
43. Sayed-Ahmed MM, Sharawy S, Shouman SA, Osman AM (1999) Reversal of doxorubicin-induced cardiac metabolic damage by L-carnitine. Phamacol Res 39: 289-295.
44. Schmidt A (1974) Measurement of lipoprotein lipase and hepatic triglyceride lipase in human postheparin plasma. Meth Enzymol 72: 325-337.
45. Silva RM, Oliveira FA, Cunha KM, Maia JL, Maciel MA, Pinto AC, Nascimento NR, Santos FA, Rao VS (2005) Cardiovascular effects of transdehydrocrotonin, a diterpene from Croton cajucara in rats. Vascul Pharmacol 43: 11-18.
46. Slater AM, White DA (1996) Effect of dietary fat on cholesterol metabolism. Regulation of plasma LDL concentrations. Nutr Res Rev 9: 241-257.
47. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL (1989) Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. New Engl J Med 320: 915.
48. Subashini R, Yogeeta S, Gnanapragasam A, Devaki T (2006) Protective effect of Nardostachys jatamansi on oxidative injury and cellular abnormalities during doxorubicin-induced cardiac damage in rats. J Pharm Pharmacol 58: 257-62.
49. Torti SV, Akimoto H, Lin K, Bilhngham ME, Torti FM (1998) Selective inhibition of muscle gene expression by oxidative stress in cardiac cells. J Mol Cell Cardiol 30: 1173-1180.
50. Tripathi YB, Tripathi E, Upadhyay A (1996) Antilipid peroxidative property of Nardostachys jatamansi. Indian J Exp Biol 34: 1150-1151.
51. Uniyal MR, Issar (1969) Commercially and traditionally important medicinal plants of Mandakini Valley Uttarakhand, Himalayas. J Res Indian Med 4: 83.
52. Whitmer UT, Ivell-Wenger JA, Rovetto MJ, Neely JR (1978) control of fatty acid metabolism in ischemic and hypoxia hearts. J Biol Chem 253: 4305-4309.