Phase III trial of albumin in malaria still lacks scientific justification

PLoS Clinical Trials

Volumn 2, Issue 2, 2007, Pages

  Woodrow, Charles J ^b   Planche, Timothy ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; GELATIN SUCCINATE; INFUSION FLUID;

ACCURACY; AFRICA; CLINICAL TRIAL; DISEASE SEVERITY; DRUG EFFICACY; DRUG FATALITY; DRUG HYPERSENSITIVITY; DRUG SAFETY; ERROR; HUMAN; INTERMETHOD COMPARISON; LETTER; LUNG EDEMA; MALARIA; MEDICAL LITERATURE; MEDICAL RESEARCH; NEUROPROTECTION; NEUROTOXICITY; THORAX RADIOGRAPHY;

EID: 34249745145     PISSN: None     EISSN: 15555887     Source Type: Journal    
DOI: 10.1371/journal.pctr.0020001     Document Type: Letter

References (5)

1. Woodrow CJ, Planche T (2007) Inadequate evidence to support phase III studies of albumin in severe malaria. PLoS Clin Trials 2: e04. doi:10.13711/journal.pctr.0020004
2. Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, et al. (2006) Volume expansion with albumin compared to Gelofusine in children with severe malaria: Results of a controlled trial. PLoS Clin Trials 1: e21. doi:10.1371/journal.pctr.0010021
3. (2006) Correction: Volume expansion with albumin compared to Gelofusine in children with severe malaria: Results of a controlled trial. PLoS Clin Trials 1: e37. doi:10.1371/journal.pctr.0010037
4. Maitland K, Akech S, Gwer S, Idro R, Fegan G, et al. (2007) Phase III trials required to resolve clinical equipoise over optimal fluid management in children with severe malaria. PLoS Clin Trials 2: e02. doi:l0.1371/journal.pctr.0020002
5. Ginsberg MD, Hill MD, Palesch YY, Ryckborst KJ, Tamariz D (2006) The ALIAS Pilot Trial: A dose-escalation and safety study of albumin therapy for acute ischemic stroke - I: Physiological responses and safety results. Stroke 37: 2100-2106.