Inadequate evidence to support phase III studies of albumin in severe malaria

PLoS Clinical Trials

Volumn 2, Issue 2, 2007, Pages

  Woodrow, Charles J ^a   Planche, Timothy ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; GELATIN SUCCINATE; PHENYTOIN;

BRAIN MALARIA; BRAIN PROTECTION; CLINICAL RESEARCH; CLINICAL TRIAL; COMATOSE PATIENT; DISEASE SEVERITY; FACTORIAL DESIGN; FLUID RESUSCITATION; HUMAN; LETTER; LUNG EDEMA; MORTALITY; NEUROPROTECTION; OUTCOMES RESEARCH; PATIENT SAFETY; RISK REDUCTION; STATISTICAL SIGNIFICANCE;

EID: 34249848611     PISSN: None     EISSN: 15555887     Source Type: Journal    
DOI: 10.1371/journal.pctr.0020004     Document Type: Letter

References (7)

1. Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, et al. (2006) Volume expansion with albumin compared to Gelofusine in children with severe malaria: Results of a controlled trial. PLoS Clin Trials 1: e21. doi:10.1371/journal.pctr.0010021
2. BBC News (2006 September 15) Hopes over new malaria treatment. Available: http://news.bbc.co.uk/2/hi/health/5346176.stm. Accessed 21 December 2006.
3. Schulz KF, Grimes DA (2002) Allocation concealment in randomised trials: Defending against deciphering. Lancet 359: 614-618.
4. Maitland K, Pamba A, English M, Peshu N, Marsh K, et al. (2005) Randomized trial of volume expansion with albumin or saline in children with severe malaria: Preliminary evidence of albumin benefit. Clin Infect Dis 40: 538-545.
5. Planche T (2005) Malaria and fluids - Balancing acts. Trends Parasitol 21: 562-567.
6. Ginsberg MD, Hill MD, Palesch YY, Ryckborst KJ, Tamariz D (2006) The ALIAS Pilot Trial: A dose-escalation and safety study of albumin therapy for acute ischemic stroke - I: Physiological responses and safety results. Stroke 37: 2100-2106.
7. Day N (2006) Fluid resuscitation in malaria: The need for new randomised clinical trials. PLoS Clin Trials 1: e24. doi:10.1371/ journal.pctr.0010024