Once daily nebulized beclomethasone is effective in maintaining pulmonary function and improving symptoms in asthmatic children

Monaldi Archives for Chest Disease - Pulmonary Series

Volumn 67, Issue 1, 2007, Pages 30-38

  La Grutta, S ^a   Nicolini, G ^b   Capristo, C ^c   Bellodi, S C ^d   Rossi, Giovanni A ^d  

^a ARNAS Hospital   (Italy)

^b CHIESI FARMACEUTICI S P A   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d G GASLINI INSTITUTE   (Italy)

Author keywords

Childhood asthma; Inhaled corticosteroids; Nebulizers; Once daily

Indexed keywords

BECLOMETASONE DIPROPIONATE; BRONCHODILATING AGENT; CREATININE; HYDROCORTISONE; PLACEBO; SALBUTAMOL; SHORT ACTING DRUG;

ADOLESCENT; ARTICLE; ASTHMA; CHILD; CHILDHOOD DISEASE; CHRONOPHARMACOLOGY; CIRCADIAN RHYTHM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CREATININE URINE LEVEL; DISEASE CONTROL; DOSAGE SCHEDULE COMPARISON; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HYDROCORTISONE URINE LEVEL; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MEDICAL NEBULIZER; MULTICENTER STUDY; PEAK EXPIRATORY FLOW; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; SYMPTOM; THRUSH; TREATMENT DURATION;

EID: 34249745103     PISSN: 11220643     EISSN: 2465101X     Source Type: Journal    
DOI: 10.4081/monaldi.2007.507     Document Type: Article

References (33)

1. Global Strategy for Asthma Management and Prevention. NIH Publication No 02-3659 Issued January, 1995 (updated 2005).
2. National Asthma Education Prevention Program (NAEPP). Expert panel report: Guidelines for the diagnosis and management of asthma-update on selected topics. J Allergy Clin Immunol 2002; 110: 141-219.
3. Bender B, Milgrom H, Rand C, Ackerson L. Psychological factors associated with medication nonadherence in asthmatic children. J Asthma 1998; 35: 347-53.
4. Guest JF, Davie AM, Ruiz FJ, Greener MJ. Switching asthma patients to a once-daily inhaled steroid improves compliance and reduces healthcare costs. Prim Care Respir J 2005; 14: 88-98.
5. Mann M, Eliasson O, Patel K, Zu Wallack RL. A comparison of the effects of bid and qid dosing on compliance with inhaled flunisolide. Chest 1992; 101: 496-9.
6. Hyland ME. Rationale for Once-Daily Therapy in Asthma Compliance Issues. Drugs 1999; 58 (Suppl. 4): 1-6.
7. Simons FE. Benefits and risks of inhaled glucocorticoids in children with persistent asthma. J Allergy Clin Immunol 1998; 102: S77-84.
8. Dubus J-C, Anhoj J. A review of once-daily delivery of anti-asthmatic drugs in children. Pediatr Allergy Immunol 2003; 14: 4-9.
9. Jonasson G, Carlsen KH, Blomqvist P. Clinical efficacy of low-dose inhaled budesonide once or twice daily in children with mild asthma not previously treated with steroids. Eur Respir J 1998; 12: 1099-104.
10. Shapiro GG, Mendelson LM, Pearlman DS. Once-daily budesonide inhalation powder (Pulmicort Turbuhaler) maintains pulmonary function and symptoms of asthmatic children previously receiving inhaled corticosteroids. Ann Allergy Asthma Immunol 2001; 86: 633-40.
11. Moller C, Stromberg L, Oldaeus G, Arwestrom E, Kjellman M. Efficacy of once daily administration of budesonide by Turbuhaler in children with stable asthma. Pediatr Pulmonol 1999; 28: 337-43.
12. Mellon M, Leflein J, Walton-Bowen K, Cruz-Rivera M, Fitzpatrick S, Smith JA. Comparable efficacy of administration with face mask, or mouthpiece of nebulized budesonide inhalation suspension for infants and young children with persistent asthma. Am J Respir Crit Care Med 2000; 162: 593-8.
13. Miller-Larsson A, Mattsson H, Hjertberg E, et al. Reversible fatty acid conjugation of budesonide. Novel mechanism for prolonged retention of topically applied steroid in airway tissue. Drug Metab Depos 1998; 26: 623-30.
14. Sabatini F, Silvestri M, Scarso L, Brazzola G, Rossi GA. The antiinflammatory activity of budesonide on activated human airway epithelial cells is lasting after removal of the drug from cultures. J Asthma 2002; 39: 11-20.
15. Gagnon M, Cote J, Milot J, Turcott H, Boulet LP. Comparative safety and efficacy of single or twice daily administration of inhaled becomethasone in moderate asthma. Chest 1994; 105: 1732-7.
16. McGivern DV, Ward M, Macfarlane JT, Roderick Smith WH. Failure of once daily inhaled corticosteroid treatment to control chronic asthma. Thorax 1984; 39: 933-4.
17. Munch EP, Laursen LC, Dirksen A, Weeke ER, Weeke B. Dose frequency in the treatment of asthmatics with inhaled topical steroids. Comparison between a twice daily and a once daily dosing regimen. Eur J Respir Dis 1985; 67: 254-60.
18. Edsbäcker S. Pharmacological factors that influence the choice of inhaled corticosteroids. Drugs 1999; 58 Suppl 4: 7-16.
19. O'Connell EJ. Optimizing inhaled corticosteroid therapy in children with chronic asthma. Pediatr Pulmonol 2005; 39: 74-83.
20. Brownlee KG. A rationale for the use of nebulized steroids in children. Eur Respir Rev 1997; 7: 177-9.
21. Dolovich MB, Ahrens RC, Hess DR, et al. Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology. Chest 2005; 127: 335-71.
22. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136: 225-244.
23. Terzano C, Cremonesi G, Panza I. Particle size and gravimetric characteristics of Clenny Aerosol, a new jet nebulizer with breath enhanced bulb. Eur Respir J 2001: 18; 99s.
24. Banov CH, Howland WC III, Lumry WR. Once-daily budesonide via Turbuhaler improves symptoms in adults with persistent asthma. Ann Allergy Asthmn Immunol 2001; 86: 627-632.
25. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995; 152: 1107-36.
26. Szefler SJ. Current concepts in asthma treatment in children. Curr Opin Pediatr 2004; 16: 299-304.
27. Adams N, Bestall J, Jones P. Inhaled beclomethasone at different doses for long-term asthma. Cochrane Database Syst Rev 2001; (1): CD002879.
28. Foe K, Brown KF, Seale JP Comparative kinetics of metabolism of beclomethasone propionate esters in human lung homogenates and plasma. J Pharm Sci 2000; 89: 1143-1150.
29. Wurthwein G, Rohdewald P. Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharm Drug Dispos 1990; 11: 381-94.
30. Agertoft L, Laulund LW, Harrison LI and Pedersen S. Influence of particle size on lung deposition and pharmacokinetics of beclomethasone dipropionate in children. Pediatr Pulmonol 2003; 35: 192-199.
31. Campbell LM. Once-daily inhaled corticosteroids in mild to moderate asthma: Improving acceptance of treatment. Drugs 1999; 58 (Suppl. 4): 25-33.
32. Diane J. Pincus, Stanley J. Szefler, Lynn M. Ackerson, Richard J. Martin. Chronotherapy of asthma with inhaled steroids: The effect of dosage timing on drug efficacy. J Allergy Clin Immunol 1995; 95: 1172-8.
33. Diane J. Pincus, Teresa R. Humeston, Richard J. Martin. Further studies on the chronotherapy of asthma with inhaled steroids: The effect of dosage timing on drug efficacy. J Allergy Clin Immunol 1997; 100: 771-4.