Efficacy of once-daily versus twice-daily administration of budesonide by turbuhaler® in children with stable asthma

Pediatric Pulmonology

Volumn 28, Issue 5, 1999, Pages 337-343

  Möller, Christian ^a   Strömberg, Leif ^b   Oldaeus, Göran ^c   Arweström, Ewa ^d   Kjellman, Max ^e  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b VRINNEVI HOSPITAL   (Sweden)

^c RYHOV COUNTY HOSPITAL   (Sweden)

^d ASTRAZENECA R AND D   (Sweden)

^e LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Asthma; Budesonide; Corticosteroids; Randomized controlled clinical trial; Turbuhaler

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; TERBUTALINE;

ADOLESCENT; ARTICLE; ASTHMA; CHILD; CHILDHOOD DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADMINISTRATION, TOPICAL; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHODILATOR AGENTS; BUDESONIDE; CHILD; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; NEBULIZERS AND VAPORIZERS; PEAK EXPIRATORY FLOW RATE;

EID: 0345202301     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0496(199911)28:5<337::AID-PPUL5>3.0.CO;2-G     Document Type: Article

References (22)

1. Carlsen K-H. Epidemiology of childhood asthma. Eur Respir J. 1994;4:4-9.
2. National Institutes of Health, National Heart, Lung and Blood Institute. Global Initiative for Asthma. Publication No. 95-3659. Bethesda, Maryland: 1995.
3. International Consensus Report on Diagnosis and Treatment of Asthma. Eur Respir J. 1992;5:601-641.
4. Ellul-Micallef R, Hansson E, Johansson SÅ. Budesonide. A new corticosteroid in bronchial asthma. Eur J Respir Dis. 1980;61: 167-173.
5. Agertoft L, Pedersen S. Effects of long term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med. 1994;88:373-381.
6. Expert Report II: Guidelines for the Diagnosis and Management of Asthma. National Asthma Education and Prevention Program; National Institutes of Health, February 1997.
7. Toogood JH, Baskerville JC, Jennings B, Lefcoe NM, Johansson SA. Influence of dosing frequency and schedule on the response of chronic asthmatics to the aerosol steroid, budesonide. J Allergy Clin Immunol. 1982;70:288-298.
8. Jones AH, Langdon CG, Lee PS, Lingham SA, Nankant JP, Follows RMA, Tollemar U, Richardson PD. Pulmicort® Turbohaler® once daily as initial prophylactic therapy for asthma. Respir Med. 1994;88:293-299.
9. Herjavecz I, Serrano A, Blomqvist P, Országos Korányi TBC. Budesonide Turbuhaler® once or twice daily in non-steroid using patients with asthma. Eur Respir J. 1997;10(Suppl 25):174s.
10. Stiksa G, Glennow C. A clinical comparison between budesonide given once and twice daily and beccotide four times daily. Ann Allergy. 1985;55:49-51.
11. McCarthy TP. The use of a once daily inhaled glucocorticosteroid (budesonide) in the management of childhood asthma. Br J Clin Res. 1993;4:55-61.
12. McGivern DV, Ward M, Macfarlane JT, Roderick Smith WH. Failure of once daily inhaled corticosteroid treatment to control chronic asthma. Thorax. 1984;39:933-934.
13. Mawhinney H, Spector SL, Kinsman RA, Siegel SC, Rachelefsky GS, Katz RM, Rohr AS. Compliance in clinical trials of two nonbronchodilator, antiasthma medications. Ann Allergy. 1991; 66:294-299.
14. Horn CR, Clark TJH. Cochrane GM. Compliance with inhaled therapy and morbidity from asthma. Respir Med. 1990;84:67-70.
15. Mann M, Eliasson O, Patel K, ZuWallack RL. A comparison of the effects of bid and qid dosing on compliance with inhaled flunisolide. Chest. 1992;101:496-499.
16. Venables TL, Addlestone MB, Smithers AJ, Blagden MD, Weston D, Gooding T, Carr EP, Follows RMA. A comparison of the efficacy and patient acceptability of once daily budesonide via Turbohaler and twice daily fluticasone propionate via disc-inhaler at an equal daily dose of 400 μg in adult asthmatics. Br J Clin Res. 1996;7:15-32.
17. Campbell LM, Gunn SD, Sweeney D, Smithers AJ, Zurek AAA, Golightly L, Turbitt ML. Once daily budesonide: effective control of moderately severe asthma with 800 μg once daily inhaled via Turbohaler when compared with 400 μg twice daily. Eur J Clin Res. 1995;7:1-14.
18. Weiner P, Weiner M, Azgad Y. Long term clinical comparison of single versus twice daily administration of inhaled budesonide in moderate asthma. Thorax. 1995;50:1270-1273.
19. Barry PW, O'Callaghan C. The effect of delay, multiple actuations and spacer static charge on the in-vitro delivery of BUD from the Nebuhaler. Br J Clin Pharmacol. 1995;40:76-78.
20. Malo J-L, Cartier A, Merland N, Ghezzo H, Buerk A, Morris J, Jennings B. Four-times-a-day dosing frequency is better than a twice-a-day regimen in subjects requiring a high-dose inhaled steroid, budesonide, to control moderate to severe asthma. Am Rev Respir Dis. 1989;140:624-628.
21. Campbell LM, Watson DG, Venables TL, Taylor MD, Richardson PDI. Once daily budesonide Turbohaler compared with placebo as initial prophylactic therapy for asthma. Br J Clin Res. 1991;2: 111-122.
22. Andersson N, Dahl L. Effect of inhaled budesonide on the HPA axis with different dosing regimens. Abstract presented at the 5th International Conference of Chronopharmacology, Amelia Island, Florida, USA, July 12-16, 1992.