Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar albino rats

International Journal of Lower Extremity Wounds

Volumn 5, Issue 3, 2006, Pages 137-143

  Shetty, B Somashekar ^a   Udupa, S L ^b   Udupa, A L ^b   Somayaji, S N ^a  

^a MELAKA MANIPAL MEDICAL COLLEGE   (India)

^b KASTURBA MEDICAL COLLEGE   (India)

Author keywords

Centella asiatica; Dead space wound; Dexamethasone; Excision wound; Incision wound; Wound healing

Indexed keywords

CENTELLA ASIATICA EXTRACT; DEXAMETHASONE; HYDROXYPROLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTELLA ASIATICA; CONTROLLED STUDY; FEMALE; GRANULATION TISSUE; HISTOLOGY; INCISION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; WOUND; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANIMALS; CENTELLA; DEXAMETHASONE; DISEASE MODELS, ANIMAL; FEMALE; GLUCOCORTICOIDS; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; TREATMENT OUTCOME; WOUND HEALING; WOUNDS AND INJURIES;

EID: 33747044908     PISSN: 15347346     EISSN: 15526941     Source Type: Journal    
DOI: 10.1177/1534734606291313     Document Type: Article

References (27)

1. Cotran RS, Kumar V, Robbins SL. Robbins pathological basis of disease. 5th ed. Philadelphia: W. B. Saunders; 1994.
2. MacKay D, Miller AL. Nutritional support for wound healing. Altern Med Rev 2003;8(4):359-77.
3. Brinkhaus B. Centella asiatica in traditional and modern phytomedicine - a pharmacological and clinical profile - part I: botany chemistry preparations. Perfusion 1998;11:466-74.
4. Brinkhaus B. Centella asiatica in traditional and modern phytomedicine - a pharmacological and clinical profile - part II: pharmacological and therapeutic profile, conclusions. Perfusion 1998;11:508-20.
5. Lubadie RP. An ehnopharmacognostic approach to the search for immunomodulators of plant origin. Planta Med 1989;55:339-48.
6. Chaudhary S, Poddar S, Sarkar S, Das PK. New multidrug regimen with indigenous drugs and dapsone in the treatment of lepromatous leprosy. Indian J Dermatol 1987;32(3):63-7.
7. Hong SS, Kim JH, Li H, Shim CK. Advanced formulation and pharmacological activity of hydrogel of the titrated extract of Centella asiatica. Arch Pharm Res 2005;28(4):502-8.
8. Poizot A, Dumez D. Modification of the kinetics of healing after iterative exeresis in the rat. Action of a triterpenoid and its derivatives on the duration of healing. C R Acad Sci Hebd Seances Acad Sci D 1978;286(10):789-92.
9. Widgerow AD, Chait LA, Stals R, Stals PJ. New innovations in scar management. Aesth Plast Surg 2000;24(3):227-34.
10. Coldren CD, Hashim P, Ali JM, Oh SK, Sinskey AJ, Rha C. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med 2003;69(8):725-32.
11. Shukla A, Rasik AM, Jain GK, Shankar R, Kulashrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacology 1999;65(1):1-11.
12. Tripathi KD. Corticosteroids in essentials of medical pharmacology. New Delhi, India: Jaypee; 1999.
13. Ehrlich PH, Hunt TK. Effect of cortisone and vitamin A on wound healing. Ann Surg 1968;167:324-8.
14. Diwan PV, Tilloo LD, Kulkarni DR. Influence of zinc sulphate on steroid suppressed wound healing. Indian J Pharmacol 1979;11:257-61.
15. Oishi Y, Fu ZW, Ohnuki Y, Kato H, Noguchi T. Molecular basis of alteration in skin collagen metabolism in response to in vivo dexamethasone treatment: effects on the synthesis of collagen type I and type III, collagenase and tissue inhibitors of metalloproteinases. Br J Dermatol 2002;47:859-63.
16. Gras MP, Verrecchia F, Uitto J, Mauviel A. Down regulation of human type VII collagen promoter activity by dexamethasone. Identification of glucocorticoid receptor binding region. Exp Dermatol 2001;10:28-32.
17. Bhaskar HN, Udupa SL, Udupa AL. Effect of nifedipine and amlodipine on dead space wound healing in rats. Indian J Exp Biol 2005;43:294-9.
18. Ehrlich HP, Hunt HK. Effect of anabolic steroid on tensile strength of a healing wound. Ann Surg 1969;170:203-8.
19. Lee KH. Studies on the mechanism of action of salicylates. 3. Effect of vitamin A on wound healing retardation action of aspirin. J Pharma Sci 1968;57(7):1238-40.
20. Morton JJ, Malone MH. Evaluation of vulnerary activity by open wound procedure in rats. Arch Int Pharmacodyn Ther 1972;196(1):117-26.
21. Neuman RE, Logan MA. The determination of collagen and elastin in tissues. J Biol Chem 1950;186:549-56.
22. Udupa SL, Udupa AL, Kulkarni DR. Influence of Tridax procumbens on lysyl oxidase activity and wound healing. Planta Med 1991;57(4):325-7.
23. Maquart FX, Chastang F, Simeon A, Birembaut P, Gillery P, Wegrowski Y. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol 1999;9(4):289-96.
24. Maquart FX, Bellon G, Gillery P, Wegrowski Y, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by triterpene extracted from Centella asiatica. Connect Tissue Res 1990;24(2):107-20.
25. Maiere CM, Chan PH. Role of superoxide dismutase in oxidative damage and neurodegenerative disorders. Neuroscientist 2002;8:323-34.
26. Senel O, Cetinkale O, Ozbay G, Ahcioglu F, Bulan R. Oxygen free radicals impair healing in ischemic rat skin. Ann Plast Surg 1997;39:516-23.
27. Shukla A, Rasik AM, Dhawan BN. Asiaticoside induced elevation of antioxidant levels in healing wounds. Phytother Res 1999;13(1);50-4.