Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in β2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells

Cell Biochemistry and Function

Volumn 25, Issue 3, 2007, Pages 323-333

  Adachi, Reiko ^a   Suzuki, Kazuhiro ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

2 integrin; Oxidative burst; Phagocyte; Phagocytosis; siRNA; Src family tyrosine kinase

Indexed keywords

BETA2 INTEGRIN; HEMATOPOIETIC CELL KINASE; PROTEIN KINASE LYN; SMALL INTERFERING RNA; ZYMOSAN;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN U937; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MACROPHAGE; NUCLEOTIDE SEQUENCE; OPSONIZATION; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY BURST; SIGNAL TRANSDUCTION;

ANTIGENS, CD18; CELL DIFFERENTIATION; HUMANS; MACROPHAGES; MOLECULAR SEQUENCE DATA; OPSONIN PROTEINS; PHAGOCYTES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-HCK; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS; ZYMOSAN;

EID: 34249707888     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1393     Document Type: Article

References (58)

1. Hubbard SR, Till JH. Protein tyrosine kinase structure and function. Annu Rev Biochem 2000; 69: 373-398.
2. Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411: 355-365.
3. Parsons SJ, Parsons JT. Src family kinases, key regulators of signal transduction. Oncogene 2004; 23: 7906-7909.
4. Bromann PA, Korkaya H, Courtneidge SA. The interplay between Src family kinases and receptor tyrosine kinases. Oncogene 2004; 23: 7957-7968.
5. Cohen DM. SRC family kinases in cell volume regulation. Am J Physiol Cell Physiol 2005; 288: C483-C493.
6. Geahlen RL, Handley MD, Harrison ML. Molecular interdiction of Src-family kinase signaling in hematopoietic cells. Oncogene 2004; 23: 8024-8032.
7. Nagaishi K, Adachi R, Matsui S, Yamaguchi T, Kasahara T, Suzuki K. Herbimycin A inhibits both dephosphorylation and translocation of cofilin induced by opsonized zymosan in macrophagelike U937 cells. J Cell Physiol 1999; 180: 345-354.
8. Edwards SW. Cell signalling by integrins and immunoglobulin receptors in primed neutrophils. Trends Biochem Sci 1995; 20: 362-367.
9. Kefalas P, Brown TR, Katz DR, Brickell PM. Identification of a phorbol ester responsive region in the myeloid-specific promoter of the c-fgr proto-oncogene. Biochem Biophys Res Commun 1995; 209: 60-65.
10. 2-production by human neutrophils. The preparation and assay of NADPH oxidase-containing particles from human neutrophils. Methods Enzymol 1984; 105: 358-365.
11. Adachi R, Takeuchi K, Suzuki K. Antisense oligonucleotide to cofilin enhances respiratory burst and phagocytosis in opsonized zymosan-stimulated mouse macrophage J774.1 cells. J Biol Chem 2002; 277: 45566-45571.
12. Thien CB, Langdon WY. Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2001; 2: 294-307.
13. Tsygankov AY, Teckchandani AM, Feshchenko EA, Swaminathan G. Beyond the RING: CBL proteins as multivalent adapters. Oncogene 2001; 20: 6382-6402.
14. Suen PW, Hie D, Caveggion E, Berton G, Damsky CH, Lowell CA. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci 1999; 112: 4067-4078.
15. Jongstra-Bilen J, Harrison R, Grinstein S. Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis. J Biol Chem 2003; 278: 45720-45729.
16. Piccardoni P, Manarini S, Federico L, et al. SRC-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells. Biochem J 2004; 380: 57-65.
17. Ortiz-Stern A, Rosales C. Fc{gamma}RIIIB stimulation promotes {beta}1 integrin activation in human neutrophils. J Leukoc Biol 2005; 77: 787-799.
18. Pereira S, Lowell C. The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J Immunol 2003; 171: 1319-1327.
19. Majeed M, Caveggion E, Lowell CA, Berton G. Role of Src kinases and Syk in Fc gamma receptor-mediated phagocytosis and phagosome-lysosome fusion. J Leukoc Biol 2001; 70: 801-811.
20. Fitzer-Attas CJ, Lowry M, Crowley MT, et al. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med 2000; 191: 669-682.
21. Ding Q, Stewart J, Jr., Olman MA, Klobe MR, Gladson CL. The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged. J Biol Chem 2003; 278: 39882-39891.
22. Miki S, Tsukada S, Nakamura Y, et al. Functional and possible physical association of scavenger receptor with cytoplasmic tyrosine kinase Lyn in monocytic THP-1-derived macrophages. FEBS Lett 1996; 399: 241-244.
23. Strzelecka-Kiliszek A, Kwiatkowska K, Sobota A. Lyn and Syk kinases are sequentially engaged in phagocytosis mediated by Fc gamma R. J Immunol 2002; 169: 6787-6794.
24. N'Diaye EN, Darzacq X, Astarie-Dequeker C, Daffe M, Calafat J, Maridonneau-Parini I. Fusion of azurophil granules with phagosomes and activation of the tyrosine kinase Hck are specifically inhibited during phagocytosis of mycobacteria by human neutrophils. J Immunol 1998; 161: 4983-4991.
25. Mocsai A, Ligeti E, Lowell CA, Berton G. Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol 1999; 162: 1120-1126.
26. Walker TR, Ruchaud-Sparagano MH, McMeekin SR, Dransfield I. A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release. Br J Pharmacol 2004; 141: 1131-1140.
27. Lowell CA, Fumagalli L, Berton G. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol 1996; 133: 895-910.
28. Yan SR, Huang M, Berton G. Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen. J Immunol 1997; 158: 1902-1910.
29. Matsuda M, Park JG, Wang DC, Hunter S, Chien P, Schreiber AD. Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides. Mol Biol Cell 1996; 7: 1095-1106.
30. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M. A critical role for Syk in signal transduction and phagocytosis mediated by Fc gamma receptors on macrophages. J Exp Med 1997; 186: 1027-1039.
31. Meng F, Lowell CA. A beta I integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. Embo J 1998; 17: 4391-4403.
32. Finkelstein LD, Shimizu Y. Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen-activated protein kinase signalling. Biochem J 2000: 345: 385-392.
33. Scholz G, Cartledge K, Dunn AR. Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase. J Biol Chem 2000; 275: 14615-14623.
34. Hannigan MO, Huang CK, Wu DQ. Roles of PI3K in neutrophil function. Curr Top Microbiol Immunol 2004; 282: 165-175.
35. Merlot S, Firtel RA. Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci 2003; 116: 3471-3478.
36. Scaife RM, Langdon WY. c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology. J Cell Sci 2000; 113: 215-226.
37. Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H. The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J Biol Chem 2001; 276: 4957-4963.
38. Uemura N, Griffin JD. The adapter protein Crk1 links Cbl to C3G after integrin ligation and enhances cell migration. J Biol Chem 1999; 274: 37525-37532.
39. Ribon V, Herrera R, Kay BK, Saltiel AR. A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. J Biol Chem 1998; 273: 4073-4080.
40. Take H, Watanabe S, Takeda K, Yu ZX, Iwata N, Kajigaya S. Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl. Biochem Biophys Res Commun 2000; 268: 321-328.
41. Suzuki K, Yamaguchi T, Oshizawa T, et al. Okadaic acid induces both augmentation and inhibition of opsonized zymosan-stimulated superoxide production by differentiated HL-60 cells. Possible involvement of dephosphorylation of a cytosolic 21K protein in respiratory burst. Biochim Biophys Acta 1995; 1266: 261-267.
42. Grogan A, Reeves E, Keep N, et al. Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. J Cell Sci 1997; 110: 3071-3081.
43. Tamura M, Kanno M, Endo Y. Deactivation of neutrophil NADPH oxidase by actin-depolymerizing agents in a cell-free system. Biochem J 2000; 349: 369-375.
44. Granfeldt D, Dahlgren C. An intact cytoskeleton is required for prolonged respiratory burst activity during neutrophil phagocytosis. Inflammation 2001; 25: 165-169.
45. Matsui S, Matsumoto S, Adachi R, et al. LIM kinase 1 modulates opsonized zymosan-triggered activation of macrophage-like U937 cells. Possible involvement of phosphorylation of cofilin and reorganization of actin cytoskeleton. J Biol Chem 2002; 277: 544-549.
46. Howlett CJ, Bisson SA, Resek ME, Tigley AW, Robbins SM. The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase. Biochem Biophys Res Commun 1999; 257: 129-138.
47. Dombrosky-Ferlan PM, Corey SJ. Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase. Oncogene 1997; 14: 2019-2024.
48. Melander F, Andersson T, Dib K. Engagement of beta2 integrins recruits 14-3-3proteins to c-Cbl in human neutrophils. Biochem Biophys Res Commun 2004; 317: 1000-1005.
49. Hunter S, Burton EA, Wu SC, Anderson SM. Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase. J Biol Chem 1999; 274: 2097-2106.
50. Feshchenko EA, Langdon WY, Tsygankov AY. Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J Biol Chem 1998; 273: 8323-8331.
51. Fernandez R, Suchard SJ. Syk activation is required for spreading and H2O2 release in adherent human neutrophils. J Immunol 1998; 160: 5154-5162.
52. 2+ signalling mechanisms of the beta 2 integrin on neutrophils: involvement of phospholipase C gamma 2 and Ins(1, 4, 5) P3. Biochem J 1996; 317: 403-409.
53. McGilvray ID, Lu Z, Wei AC, Rotstein OD. MAP-kinase dependent induction of monocytic procoagulant activity by beta2-integrins. J Surg Res 1998; 80: 272-279.
54. Zheng L, Sjolander A, Eckerdal J, Andersson T. Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav. Proc Natl Acad Sci USA 1996; 93: 8431-8436.
55. Dib K, Melander F, Andersson T. Role of p190RhoGAP in beta 2 integrin regulation of RhoA in human neutrophils. J Immunol 2001; 166: 6311-6322.
56. Fuortes M, Jin WW, Nathan C. Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor. J Cell Biol 1994; 127: 1477-1483.
57. Dib K. BETA 2 integrin signaling in leukocytes. Front Biosci 2000; 5: D438-D451.
58. Matsui S, Adachi R, Kusui K, et al. U73122 inhibits the dephosphorylation and translocation of cofilin in activated macrophage-like U937 cells. Cell Signal 2001; 13: 17-22.