Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: Cellular localization is not dependent on the expression of caveolin proteins

European Journal of Cell Biology

Volumn 86, Issue 6, 2007, Pages 345-352

  Fernow, Inga ^a   Icking, Ann ^a   Tikkanen, Ritva ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Caveolae; Caveolin; Flotillin; Microdomain; Rafts; Reggie

Indexed keywords

CAVEOLIN; CAVEOLIN 1; CAVEOLIN 2; FLOTILLIN 1; FLOTILLIN 2;

ANIMAL CELL; ARTICLE; BIOASSAY; CAVEOLA; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT;

EID: 34249701297     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcb.2007.03.004     Document Type: Article

References (24)

1. Baumann C.A., Ribon V., Kanzaki M., Thurmond D.C., Mora S., Shigematsu S., Bickel P.E., Pessin J.E., and Saltiel A.R. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407 (2000) 202-207
2. Bickel P.E., Scherer P.E., Schnitzer J.E., Oh P., Lisanti M.P., and Lodish H.F. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J. Biol. Chem. 272 (1997) 13793-13802
3. Fra A.M., Williamson E., Simons K., and Parton R.G. De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin. Proc. Natl. Acad. Sci. USA 92 (1995) 8655-8659
4. Glebov O.O., Bright N.A., and Nichols B.J. Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Nat. Cell Biol. 8 (2006) 46-54
5. Ikezu T., Ueda H., Trapp B.D., Nishiyama K., Sha J.F., Volonte D., Galbiati F., Byrd A.L., Bassell G., Serizawa H., Lane W.S., Lisanti M.P., and Okamoto T. Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types. Brain Res. 804 (1998) 177-192
6. Ju H., Zou R., Venema V.J., and Venema R.C. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. J. Biol. Chem. 272 (1997) 18522-18525
7. Lang D.M., Lommel S., Jung M., Ankerhold R., Petrausch B., Laessing U., Wiechers M.F., Plattner H., and Stuermer C.A. Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons. J. Neurobiol. 37 (1998) 502-523
8. Lipardi C., Mora R., Colomer V., Paladino S., Nitsch L., Rodriguez-Boulan E., and Zurzolo C. Caveolin transfection results in caveolae formation but not apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins in epithelial cells. J. Cell Biol. 140 (1998) 617-626
9. Mora R., Bonilha V.L., Marmorstein A., Scherer P.E., Brown D., Lisanti M.P., and Rodriguez-Boulan E. Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1. J. Biol. Chem. 274 (1999) 25708-25717
10. Morrow I.C., Rea S., Martin S., Prior I.A., Prohaska R., Hancock J.F., James D.E., and Parton R.G. Flotillin-1/reggie-2 traffics to surface raft domains via a novel Golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation. J. Biol. Chem. 277 (2002) 48834-48841
11. Neumann-Giesen C., Falkenbach B., Beicht P., Claasen S., Luers G., Stuermer C.A., Herzog V., and Tikkanen R. Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Biochem. J. 378 (2004) 509-518
12. Neumann-Giesen C., Fernow I., Amaddii M., and Tikkanen R. Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J. Cell Sci. 120 (2007) 395-406
13. Rajendran L., Masilamani M., Solomon S., Tikkanen R., Stuermer C.A., Plattner H., and Illges H. Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells. Proc. Natl. Acad. Sci. USA 100 (2003) 8241-8246
14. Reuter A., Binkle U., Stuermer C.A., and Plattner H. PrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cells. Cell. Mol. Life Sci. 61 (2004) 2092-2099
15. Schilling K., Opitz N., Wiesenthal A., Oess S., Tikkanen R., Muller-Esterl W., and Icking A. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol. Biol. Cell 17 (2006) 3870-3880
16. Schroeder W.T., Stewart-Galetka S., Mandavilli S., Parry D.A., Goldsmith L., and Duvic M. Cloning and characterization of a novel epidermal cell surface antigen (ESA). J. Biol. Chem. 269 (1994) 19983-19991
17. Schulte T., Paschke K.A., Laessing U., Lottspeich F., and Stuermer C.A. Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration. Development 124 (1997) 577-587
18. Simons K., and Ikonen E. Functional rafts in cell membranes. Nature 387 (1997) 569-572
19. Simons K., and Toomre D. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1 (2000) 31-39
20. Stuermer C.A., Lang D.M., Kirsch F., Wiechers M., Deininger S.O., and Plattner H. Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. Mol. Biol. Cell 12 (2001) 3031-3045
21. Stuermer C.A., Langhorst M.F., Wiechers M.F., Legler D.F., Von Hanwehr S.H., Guse A.H., and Plattner H. PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction. FASEB J. 18 (2004) 1731-1733
22. Volonte D., Galbiati F., Li S., Nishiyama K., Okamoto T., and Lisanti M.P. Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. J. Biol. Chem. 274 (1999) 12702-12709
23. Zhou M., Parr R.D., Petrescu A.D., Payne H.R., Atshaves B.P., Kier A.B., Ball J.M., and Schroeder F. Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo. Biochemistry 43 (2004) 7288-7306
24. Zurzolo C., van't Hof W., van Meer G., and Rodriguez-Boulan E. VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells. EMBO J. 13 (1994) 42-53