Sterilized ophthalmic hydrogels with hydroxypropyl methylcellulose: Determination and mathematical treatment of flow properties

Pharmaceutical Development and Technology

Volumn 12, Issue 1, 2007, Pages 55-60

  Zatloukal, Zdenek ^a   Šklubalová, Zdenka ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Hydrogel; Hydroxypropyl methylcellulose; Steam sterilization; Viscosity

Indexed keywords

AGENTS ACTING ON THE EYE; ATROPINE; ELECTROLYTE; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; PILOCARPINE; SCOPOLAMINE BROMIDE; SODIUM CHLORIDE; DRUG DERIVATIVE; EYE DROPS;

ANALYTIC METHOD; ARTICLE; FLOW KINETICS; FLOW MEASUREMENT; HYDROGEL; INSTRUMENT STERILIZATION; PRIORITY JOURNAL; VISCOMETRY; VISCOSITY; ALGORITHM; CHEMISTRY; STATISTICAL MODEL;

ALGORITHMS; ELECTROLYTES; HYDROGELS; METHYLCELLULOSE; MODELS, STATISTICAL; OPHTHALMIC SOLUTIONS; RHEOLOGY; STERILIZATION; VISCOSITY;

EID: 34249686033     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450601166593     Document Type: Article

References (12)

1. Kaur, I.P.; Kanwar, M. Ocular preparations: The formulation approach. Drug Dev. Ind. Pharm. 2002, 28 (5), 473-493.
2. Zignani, M.; Tabatabay, C.; Gurny, R. Topical semi-solid drug delivery: kinetics and tolerance of ophthalmic hydrogels. Adv. Drug. Del. Rev. 1995, 16 (1), 51-60.
3. th Ed., Aubin: Ligugé, France, 2004.
4. Vandenbossche, G.M.R.; Remon, J.P. Influence of the sterilization process on alginate dispersions. J. Pharm. Pharmacol. 1993, 45 (5), 484-486.
5. Bindal, A.; Narsimhan, G.; Hem, S.C.; Kulshreshtha, A. Effect of steam sterilization on the rheology of polymer solutions. Pharm. Dev. Technol. 2003, 8 (3), 219-228.
6. Weyenberg, W.; Todorov, V.; Ludwig, A. Rheological evaluation of the influence of sterilisation on ocular gels using an experimental design. Die Pharmazie 2004, 59 (2), 121-125.
7. Duggirala, S.; DeLuca P.P. Rheological characterization of cellulosic and alginate polymers. PDA J. Pharm. Sci. Technol. 1996, 50 (5), 290-296.
8. Barnes, H.A. The yield stress - a review or "panta rei" - everything flows? J. Non-newtonian Fluid Mech. 1999, 81 (1-2), 133-178.
9. Marquardt, D.; Sucker, H. Oil-in-water-emulsion gels: Determination and mathematical treatment of flow properties. Eur. J. Pharm. Biopharm. 1998, 46 (1), 115-124.
10. Zatloukal, Z. Sterilized ophthalmic hydrogels with hydroxypropyl methylcellulose. Cesk. Slov. Farm. 1989, 38, 368-370.
11. Bailey, W.J.; Weir, I.S. Investigation of methods for direct rheological model parameter estimation. J. Petrol. Sci. Technol. 1998, 21 (1-2), 1-13.
12. Zatloukal, Z. Influencing pseudoplastic hydrogels by an addition of pilocarpine hydrochloride. Cesk. Slov. Farm. 2003, 52, 131-135.