A Phase I/II Trial of Topotecan and Radiation Therapy for Brain Metastases in Patients With Solid Tumors

International Journal of Radiation Oncology Biology Physics

Volumn 68, Issue 3, 2007, Pages 839-844

  Hedde, Jan Peter ^a   Neuhaus, Thomas ^b   Schüller, Heinrich ^c   Metzler, Ute ^a   Schmidt Wolf, Ingo G H ^c   Kleinschmidt, Rolf ^c   Losem, Christoph ^c   Lange, Oliver ^d   Grohe, Christian ^d   Stier, Sebastian ^d   Ko, Yon Dschun ^b  

^a KRANKENHAUS MERHEIM   (Germany)

^b Johanniter Krankenhaus   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d Medical Practice of Radiotherapy   (Germany)

Author keywords

Brain metastases; Radiation; Topotecan

Indexed keywords

BLOOD; BRAIN; CHEMOTHERAPY; RADIOTHERAPY; TUMORS;

BRAIN METASTASES; CHEMOTHERAPEUTICS; TOPOTECAN;

ONCOLOGY;

DEXAMETHASONE; TOPOTECAN;

ADULT; AGED; ANEMIA; ARTICLE; BRAIN METASTASIS; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONSTIPATION; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EFFICACY; DRUG INFUSION; DRUG MEGADOSE; DRUG RESPONSE; EDEMA; EVALUATION; FATIGUE; FEASIBILITY STUDY; FEMALE; FEVER; HUMAN; INFECTION; LEUKOPENIA; MALE; NAUSEA; NEUROPATHY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PERIPHERAL NEUROPATHY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE; RECOMMENDED DRUG DOSE; SOLID TUMOR; STOMATITIS; THROMBOCYTOPENIA; VOMITING; WHOLE BRAIN RADIOTHERAPY;

ADULT; AGED; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; BREAST NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEASIBILITY STUDIES; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; TOPOTECAN; TREATMENT OUTCOME;

EID: 34249685586     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.01.004     Document Type: Article

References (29)

1. Riva M., Landonio G., Arena O., et al. Pathophysiology, clinical manifestations and supportive care of metastatic brain cancer. Forum (Genova) 11 (2001) 4-26
2. Jawahar A., Matthew R.E., Minagar A., et al. Gamma knife surgery in the managment of brain metatsases from lung carcinoma: A retrosprective analysis of survival. Local tumor control, and freedom from new brain metastases. J Neurosurg 100 (2004) 842-847
3. Patchell R.A., Tibbs P.A., Wlash J.W., et al. A randomized trial of surgery in the treatment of single metastases of the brain. N Engl J Med 322 (1990) 494-500
4. Andrews D.W., Scott C.B., Sperduto P.W., et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial. Lancet 363 (2004) 1665-1672
5. Lagerwaard F.J., Levendag P.C., Nowak P.J., et al. Identification of prognostic factors in patients with brain metastases: A review of 1292 patients. Int J Radiat Oncol Biol Phys 43 (1999) 795-803
6. Postmus P.E. Brain metastases from small cell lung cancer: Chemotherapy, radiotherapy, or both. Semin Radiat Oncol 5 (1995) 69-73
7. Lassman A.B., and DeAngelis L.M. Brain metastases. Neurol Clin 21 (2003) 1-23
8. Peereboom D.M. Chemotherapy in brain metastases. Neurosurgery 57 5 Suppl (2005) S54-S65
9. Kaba S.E., Kyritsis A.P., Hess K., et al. TPDC-FuHu chemotherapy for the treatment of recurrent metastastic brain tumors. J Clin Oncol 15 (1997) 1063-1070
10. Franciosi V., Cocconi G., Michiara M., et al. Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, Nonsmall cell lung carcinoma, or malignant melanoma: A prospective study. Cancer 85 (1999) 1599-1605
11. Cortes J., Rodriguez J., Aramendia J.M., et al. Front-line paclitaxel/ciplatin-based chemotherapy in brain metastases from non-small-cell lung cancer. Oncology 64 (2003) 28-35
12. Bernardo G., Cuzzoni Q., Strada M.R., et al. First-line chemotherapy with vinorelbine, gemicitabine, and carboplatin in the treatment of brain metastases from non-small-cell lung cancer: A phase II study. Cancer Invest 20 (2002) 293-302
13. von Pawel J., Schiller J.H., Shepherd F.A., et al. Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. J Clin Oncol 17 (1999) 658-667
14. Sung C., Blaney S.M., Cole D.E., et al. A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid. Cancer Res 54 (1994) 5118-5122
15. Baker S.D., Heideman R.L., Crom W.R., et al. Cerebrospinal fluid pharmacokinteics and penetration of continous infusion topotecan in children with central nervous system tumors. Cancer Chemother Pharamcol 37 (1996) 195-202
16. Oberhoff C., Kieback D.G., Wurstlein R., et al. Topotecan chemotherapy in patients with breast cancer and brain metastases: Results of a pilot study. Onkologie 24 (2001) 256-260
17. Schutte W., Manegold C., von Pawel J.V., et al. Topotecan-a new treatment option in the therapy of brain metastases of lung cancer. Front Radiat Ther Oncol 33 (1999) 354-363
18. Ardizzoni A., Hansen H., Dombernowsky P., et al., The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Drug Development Office, and the Lung Cancer Cooperative Group. Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: A Phase II study in patients with refractory and sensitive disease. J Clin Oncol 15 (1997) 2090-2096
19. Korfel A., Oehm C., von Pawel J., et al. Response to topotecan of symptomatic brain metastases of smll-cell lung cancer also after whole-brain irradiation. A multicentre Phase II study. Eur J Cancer 38 (2002) 1724-1729
20. Wong E.T., and Berkenbilt A. The role of topotecan in the treatment of brain metastases. Oncologist 9 (2004) 68-79
21. Ushio Y., Arita N., Hayakawa T., et al. Chemotherapy of brain metastases from lung carcinoma: A controlled randomized study. Neurosurgery 28 (1991) 201-205
22. Antonadou D., Paraskevaidis M., Sarris G., et al. Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases. J Clin Oncol 20 (2002) 3644-3650
23. Glantz M.J., Chamberlain M.C., Chang S.M., et al. The role of paclitaxel in the treatment of promary and metastatic brain tumors. Semin Radiat Oncol 9 2 Suppl 1 (1999) 27-33
24. Kim J.H., Kim S.H., Kolozsvary A., et al. Potentiation of radiation response in human carcinoma cells in vitro and murine fibrosarcoma in vivo by topotecan, an inhibitor of DNA topoisomerase I. Int J Radiat Oncol Biol Phys 22 (1992) 515-518
25. Lamond J.P., Mehta M.P., and Boothman D.A. The potential of topoisomerase I inhibitors in the treatment of CNS malignancies: Report of a synergistic effect between topotecan and radiation. J Neurooncol 30 (1996) 1-6
26. Zamboni W.C., Luftner D.I., Egorin M.J., et al. The effects of increasing topotecan infusion from 30 minutes to 4 hours on the duration of exposure in cerebrospinal fluid. Ann Oncol 12 (2001) 119-122
27. Mattern M.R., Hofmann G.A., McCabe F.L., et al. Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864). Cancer Res 51 (1991) 5813-5816
28. Gruschow K., Klautke G., and Fietkau R. Phase I/II clinical trial of concurrent radiochemotherapy in combination with topotecan for the treatment of brain metastases. Eur J Cancer 38 (2002) 367-374
29. Kocher M., Eich H.T., Semrau R., et al. Phase I/II trial of simultaneous whole-brain irradiation and dose-escalating topotecan for brain metastases. Strahlenther Onkol 181 (2005) 20-25