CD7-CD56-positive acute myeloid leukemias are characterized by constitutive phosphorylation of the NF-kB subunit p65 at Ser536 [3]

Leukemia

Volumn 21, Issue 6, 2007, Pages 1305-1306

  Morotti, A ^a   Parvis, G ^a   Cilloni, D ^a   Familiari, U ^b   Pautasso, M ^b   Bosa, M ^a   Messa, F ^a   Arruga, F ^a   Defilippi, I ^a   Catalano, R ^a   Rosso, V ^a   Carturan, S ^a   Bracco, E ^a   Guerrasio, A ^a   Saglio, G ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b SAN LUIGI GONZAGA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD56 ANTIGEN; CD7 ANTIGEN; I KAPPA B KINASE; SERINE; TRANSCRIPTION FACTOR RELA;

ACUTE GRANULOCYTIC LEUKEMIA; ALLOGENIC BONE MARROW TRANSPLANTATION; CANCER MORTALITY; CANCER RESISTANCE; CELL ISOLATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LETTER; LEUKEMIA CELL; LEUKEMOGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

EID: 34249683738     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404581     Document Type: Letter

References (8)

1. Suzuki R, Yamamoto K, Seto M, Kagami Y, Ogura M, Yatabe Y et al. CD7 and CD56 myeloid/natural killer cell precursor acute leukemia: A distinct hematolymphoid disease entity. Blood 1997; 90: 2417-2428.
2. Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001; 98: 2301-2307.
3. Mattioli I, Sebald A, Bucher C, Charles RP, Nakano H, Doi T et al. Transient and selective NF-kB p65 Serine 536 phosphorylation induced by T cell costimulation is mediated by IkB kinase and controls the kinetics of p65 nuclear import. J Immunol 2004; 172: 6336-6344.
4. Buss H, Dorrie A, Schmitz ML, Hoffmann E, Resch K, Kracht M. Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31 -mediated interleukin-8 transcription. J Biol Chem 2004; 279 55633-55643.
5. Sasakil CY, Barberi TJ, Ghosh P, Longo DL. Phosphorylation of RelA/p65 on Serine 536 defines an IkB-α independent NF-kB pathway. J Biol Chem 2005; 280: 34538-34547.
6. Morotti A, Cilloni D, Messa F, Arruga F, Defilippi I, Carturan S et al. Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells. Cancer 2006; 106: 1188-1196.
7. Baumgartner B, Weber M, Quirling M, Fischer C, Page S, Adam M et al. Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts. Leukemia 2002; 16: 2062-2071.
8. Song Y-J, Jen K-Y, Soni V, Kieff E, Cahir-McFarland E. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA Serine 536 phosphorylation and NF-{kappa}B activation. PNAS 2006; 103: 2689-2694.