The effect of delayed preconditioning on connexin 43 in ischemic myocardium

Biochemistry and Cell Biology

Volumn 85, Issue 2, 2007, Pages 175-181

  Lin, Jijin ^a,b   Li, Yuguang ^b   Lin, Shuguang ^a   Liang, Qing ^b   Tan, Xuerui ^b  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Connexin 43; Gap junction; Immunohistochemistry; Ischemic preconditioning

Indexed keywords

ANIMALS; CONFOCAL MICROSCOPY; MUSCLE;

CONNEXIN 43; GAP JUNCTION; IMMUNOHISTOCHEMISTRY; ISCHEMIC MYOCARDIUM; ISCHEMIC PRECONDITIONING;

BIOCHEMISTRY;

CONNEXIN 43;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; CONDITIONING; CONFERENCE PAPER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOG; FEMALE; HEART MUSCLE; HEART MUSCLE ISCHEMIA; IMMUNOHISTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPERFUSION; WESTERN BLOTTING;

ANIMALS; CONNEXIN 43; DOGS; FEMALE; INTERCELLULAR JUNCTIONS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; TIME FACTORS;

CANIS FAMILIARIS;

EID: 34249667710     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/O07-003     Document Type: Conference Paper

References (30)

1. Beyer, E.C. 1990. Molecular cloning and developmental expression of two chick embryo gap junction proteins. J. Biol. Chem. 265: 14439-14443.
2. Beyer, E.C., Davis, L.M., Saffitz, J.E., and Veenstra, R.D. 1995. Cardiac intercellular communication: consequences of connexin distribution and diversity. Braz. J. Med. Biol. Res. 28: 415-425.
3. Bolli, R. 1996. The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview. Basic Res. Cardiol. 91: 57-63.
4. Bowling, N., Huang, X., Sandusky, G.E., Fouts, R.L., Mintze, K., Esterman, M., et al. 2001. Protein kinase C-alpha and -epsilon modulate connexin-43 phosphorylation in human heart. J. Mol. Cell. Cardiol. 33: 789-798. doi:10.1006/jmcc.2000.1349.
5. Daleau, P., Boudriau, S., Michaud, M., Jolicoeur, C., and Kingma, J.G. Jr. 2001. Preconditioning in the absence or presence of sustained ischemia modulates myocardial Cx43 protein levels and gap junction distribution. Can. J. Physiol. Pharmacol. 79: 371-378.
6. Davis, L.M., Kenter, H.L., Beyer, E.C., and Saffitz, J.E. 1994. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties. J. Am. Coll. Cardiol. 24: 1124-1132.
7. Gourdie, R.G., Harfst, E., Severs, N.J., and Green, C.R. 1990. Cardiac gap junctions in rat ventricle: Localization using site-directed antibidies and laser scaning confocal microscopy. Cardioscience, 1: 75-82.
8. Gourdie, R.G., Green, C.R., and Severs, N.J. 1991. Gap junction distribution in adult mammalian myocardium revealed by an antipeptide antibody and laser scanning confosal microscopy. J. Cell Sci. 99: 41-55.
9. Gourdie, R.G., Green, C.R., Severs, N.J., and Thompson, R.P. 1992. Immunolabeling patterns of gap junction connexins in the developing and mature rat heart. Anat. Embryol. (Berl.), 185: 363-378.
10. Gros, D.B., and Jongsma, H.J. 1996. Connexins in mammalian heart. Bioessays, 18: 719-730. doi:10.1002/bies.950180907.
11. Huang, X.D., Sandushy, G.E., and Zipes, D.P. 1999. Heterogeneous loss of connexin43 protein in ischemic dog hearts. J. Cardiovasc. Electrophysiol. 10: 79-91.
12. Jongsma, H.J., and Gros, D. 1991. The cardiac connection. News Physiol. Sci. 6: 34-40.
13. Jongsma, H.J., and Wilders, R. 2000. Gap junction in cardiovascular disease. Circ. Res. 86: 1193-1197.
14. Kanter, H.L., Laing, J.G., Beyer, E.C., Green, K.G., and Saffitz, J.E. 1993. Multiple connexins colocalize in canine ventricular myocyte gap junctions. Circ. Res. 73: 344-350.
15. Kanter, H.L., Saffitz, J.E., and Beyer, E.C. 1992. Cardiac myocytes express multiple gap junction proteins. Circ. Res. 70: 438-444.
16. Kloner, R.A., Bolli, R., Marban, E., Reinlib, L., and Braunwald, E. 1998. Medical and cellular implications of stunning, hibernation and preconditioning: an NHLBL workshop. Circulation, 97: 1848-1867.
17. Kuzuya, T., Hoshida, S., Yamashita, N., Fuji, H., Oe, H., Hori, M., Kamada, T., and Tada, M. 1993. Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia. Circ. Res. 72: 1293-1299.
18. Laing, J.G., Tadros, P.N., Green, K., Saffitz, J.E., and Beyer, E.C. 1998. Proteolysis of connexin43 -containing gap junctions in normal and heat-stressed cardiac myocytes. Cardiovasc. Res. 38: 711-718. doi:10.1016/S0008-6363(98)00060-1.
19. Laing, J.G., Tadros, P.N., Westphale, E.M., and Beyer, E.C. 1997. Degradation of connexin43 gap junctions involves both the proteasome and the lysosome. Exp. Cell Res. 236: 482-492. doi:10.1006/excr.1997.3747.
20. Marber, M.S., Latchman, D.S., Walker, J.M., and Yellon, D.M. 1993. Cardiac stress protein elevation 24 hrs after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation, 88: 1264-1272.
21. Murry, C.E., Jennings, R.B., and Reimer, K.A. 1986. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 74: 1124-1136.
22. Peters, N.S. 1995. Myocardial gap junction organization in ischemia and infarction. Microsc. Res. Tech. 31: 375-386. doi:10.1002/jemt.1070310507.
23. Peters, N.S., Green, C.R., Poole-Wilson, P.A., and Severs, N.J. 1993. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation, 88: 864-875.
24. Reed, K.E., Westphale, E.M., Larson, D.M., Wang, H.Z., Veenstra, R.D., and Beyer, E.C. 1993. Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J. Clin. Invest. 91: 997-1004.
25. Schwanke, U., Konietzka, I., Duschin, A., Li, X., Schulz, R., and Heusch, G. 2002. No ischemic preconditioning in heterozygous connexin43-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 283: H1740-H1742.
26. Schwartz, A.L., and Ciechanover, A. 1999. The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu. Rev. Med. 50: 57-74. doi:10.1146/annurev.med.50.1.57.
27. Toyofuku, T., Yabuki, M., Otsu, K., Kuzuya, T., Hori, M., and Tada, M. 1998. Direct association of the gap junction protein connexin43 with ZO-1 in cardiac myocytes. J. Biol. Chem. 273: 12725-12731. doi:10.1074/jbc.273. 21.12725.
28. Tyagi, P., and Tayal, G. 2002. Ischemic preconditioning of myocardium. Acta Pharmacol. Sin. 23: 865-870.
29. Van Kempen, M.J., Fromaget, C., Gros, D., Moorman, A.F., and Lamers, W.H. 1991. Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart. Circ. Res. 68: 1638-1651.
30. Weinbrenner, C., Liu, G.S., Cohen, M.V., and Downey, J.M. 1997. Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinases correlates with the protection of preconditioning in rabbit heart. J. Mol. Cell. Cardiol. 29: 2383-2391. doi:10.1006/jmcc. 1997.0473.