Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3412-3416

  Dang, Qun ^a   Liu, Yan ^a   Rydzewski, Robert M ^a   Brown, Brian S ^a   Robinson, Edward ^a   van Poelje, Paul D ^a   Colby, Timothy J ^a   Erion, Mark D ^a  

^a Metabasis Therapeutics Inc   (United States)

Author keywords

Bis (para methoxy)benzyl phosphonate ester; Phosphonate; Prodrug

Indexed keywords

BENZYL DERIVATIVE; ESTER DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PRODRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL MEMBRANE PERMEABILITY; DRUG SYNTHESIS; LIVER CELL; LIVER MICROSOME; NONHUMAN; QUANTUM YIELD; RAT; REACTION ANALYSIS;

ANIMALS; DRUG STABILITY; HEPATOCYTES; MODELS, CHEMICAL; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PRODRUGS; RATS; TIME FACTORS;

RATTUS;

EID: 34249666644     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.089     Document Type: Article

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