The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and d, l-sotalol

Journal of Pharmacological and Toxicological Methods

Volumn 56, Issue 1, 2007, Pages 11-17

  Limberis, James T ^a   McDermott, Jeff S ^a   Salmen, Heinz J ^a   Su, Zhi ^a   Mikhail, Ann ^a   Green, Jonathon R ^a   Cox, Bryan F ^a   Gintant, Gary A ^a   Martin, Ruth L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Action potential; Canine Purkinje fiber; Cardiac repolarization; Methods; Plasma protein binding; Q T prolongation

Indexed keywords

CALCIUM; CHLORIDE; CISAPRIDE; GLUCOSE; PLASMA PROTEIN; POTASSIUM; RECOMBINANT HUMAN SERUM ALBUMIN; RISPERIDONE; SODIUM; SOTALOL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCULATION; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG PROTEIN BINDING; ELECTROPHYSIOLOGY; HEART REPOLARIZATION; IN VITRO STUDY; MICROELECTRODE; NONHUMAN; PROTEIN BINDING; PURKINJE FIBER; TEMPERATURE MEASUREMENT;

ACTION POTENTIALS; ANIMALS; BLOOD PROTEINS; CISAPRIDE; DOGS; HUMANS; ISOTONIC SOLUTIONS; MODELS, BIOLOGICAL; PROTEIN BINDING; PURKINJE FIBERS; RISPERIDONE; SERUM ALBUMIN; SOTALOL;

EID: 34249654032     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2007.01.001     Document Type: Article

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