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(a) Horton, D. A.; Bourne, G. T.; Smythe, M. L. Chem. Rev. 2003, 103, 893.
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Horton, D.A.1
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3
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34249313401
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Bahr, M, Ed, Wiley-VCH: Weinheim, Germany
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Jiang, L.; Buchwald, S. L. In Neuroprotection. Mechanisms and Therapies; Bahr, M., Ed.; Wiley-VCH: Weinheim, Germany, 2004.
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Neuroprotection. Mechanisms and Therapies
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Jiang, L.1
Buchwald, S.L.2
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4
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(a) Back, T. G.; Wulff, J. E. Angew. Chem., Int. Ed. 2004, 43, 1268.
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Back, T.G.1
Wulff, J.E.2
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5
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0035938374
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(b) Link, J. T.; Sorensen, B.; Liu, G.; Pei, Z.; Reilly, E. B.; Leitza, S.; Okasinski, G. Bioorg. Med. Chem. Lett. 2001, 11, 973.
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Link, J.T.1
Sorensen, B.2
Liu, G.3
Pei, Z.4
Reilly, E.B.5
Leitza, S.6
Okasinski, G.7
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6
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32644435758
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For other examples of selective animation of polyhalo substrates, see: a
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For other examples of selective animation of polyhalo substrates, see: (a) Peng, Z.; Journet, M.; Humphrey, G. Org. Lett. 2006, 8, 395.
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Org. Lett
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Peng, Z.1
Journet, M.2
Humphrey, G.3
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7
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6344277027
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(b) Kuethe, J. T.; Wong, A.; Davies, I. W. J. Org. Chem. 2004, 69, 7752.
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J. Org. Chem
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Kuethe, J.T.1
Wong, A.2
Davies, I.W.3
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8
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0036454157
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(c) Maes, B.; Loones, K.; Jonckers, T. H.; Lemiere, G.; Dommisse, R. A.; Haemers, A. Synlett 2002, 12, 1995.
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Maes, B.1
Loones, K.2
Jonckers, T.H.3
Lemiere, G.4
Dommisse, R.A.5
Haemers, A.6
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9
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0347411081
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Ji, J.; Li, T.; Bunnelle, W. H. Org. Lett. 2003, 5, 4611.
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Ji, J.1
Li, T.2
Bunnelle, W.H.3
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11
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34249276421
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For an example of carbanion addition to le at elevated temperatures, see WO2005005398.
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For an example of carbanion addition to le at elevated temperatures, see WO2005005398.
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12
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33845585240
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(a) Schaub, T.; Backes, M.; Radius, U. J. Am. Chem. Soc. 2006, 128, 15964.
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Schaub, T.1
Backes, M.2
Radius, U.3
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14
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0035799878
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For an analogous result with 2-chloro-5-iodopyridine and a biscarbene ligand, see
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For an analogous result with 2-chloro-5-iodopyridine and a biscarbene ligand, see: Cheng, J.; Trudell, M. L. Org. Lett. 2001, 3, 1371.
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Org. Lett
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Cheng, J.1
Trudell, M.L.2
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15
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0034740448
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a values are in the following rank order: piperidine (11.24) > [1,4]-oxazepine > phenyl piperazine > morpholine > bis(2-methoxyethyl)amine (8.67).
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a values are in the following rank order: piperidine (11.24) > [1,4]-oxazepine > phenyl piperazine > morpholine > bis(2-methoxyethyl)amine (8.67).
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16
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12144276704
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For an example of nucleophilic substitution of 3-fluoropyridine with imidazole, see
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For an example of nucleophilic substitution of 3-fluoropyridine with imidazole, see: Denton, T.; Zhang, X.; Cashman, J. J. Med. Chem. 2005, 48, 224.
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J. Med. Chem
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Denton, T.1
Zhang, X.2
Cashman, J.3
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