Bleomycin induces caveolin-1 and -2 expression in epithelial lung cancer A549 cells

Anticancer Research

Volumn 27, Issue 3 A, 2007, Pages 1343-1351

  Linge, Annett ^a   Morishima, Nobuhiro ^b   Kasper, Michael ^a   Barth, Kathrin ^a,c  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b RIKEN   (Japan)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

A549; Apoptosis; Bleomycin; Caveolin

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BLEOMYCIN; CAVEOLIN 1; CAVEOLIN 2;

APOPTOSIS; CANCER CELL; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LUNG CANCER; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SUCROSE DENSITY GRADIENT CENTRIFUGATION; UPREGULATION; WESTERN BLOTTING;

ADENOCARCINOMA; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLEOMYCIN; CASPASE 8; CASPASE 9; CAVEOLIN 1; CAVEOLIN 2; CELL LINE, TUMOR; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MEMBRANE MICRODOMAINS;

EID: 34249281326     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. Razani B, Woodman SE and Lisanti MP: Caveolae: from cell biology to animal physiology. Pharmacol Rev 54: 431-467, 2002.
2. Williams TM and Lisanti MP: The Caveolin genes: from cell biology to medicine. Ann Med 36: 584-595, 2004.
3. Newman GR, Campbell L, von Ruhland C, Jasani B and Gumbleton M: Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar epithelial type I cell function. Cell Tissue Res 295: 111-120, 1999.
4. Kasper M, Reimann T, Hempel U, Wenzel KW, Bierhaus A, Schuh D, Dimmer V, Haroske G and Muller M: Loss of caveolin expression in type I pneumocytes as an indicator of subcellular alterations during lung fibrogenesis. Histochem Cell Biol 109: 41-48, 1998.
5. Fielding CJ and Fielding PE: Relationship between cholesterol trafficking and signaling in rafts and caveolae. Biochim Biophys Acta 1610: 219-228, 2003.
6. Quest AF, Leyton L and Parraga M: Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease. Biochem Cell Biol 82: 129-144, 2004.
7. Rothberg KG, Heuser JE, Donzell WC, Ying YS, Glenney JR and Anderson RG: Caveolin, a protein component of caveolae membrane coats. Cell 68: 673-682, 1992.
8. Norkin LC: Caveolae in the uptake and targeting of infectious agents and secreted toxins. Adv Drug Deliv Rev 49: 301-315, 2001.
9. Zundel W, Swiersz LM and Giaccia A: Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide. Mol Cell Biol 20: 1507-1514, 2000.
10. Liu J, Lee P, Galbiati F, Kitsis RN and Lisanti MP: Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation. Am J Physiol Cell Physiol 280: C823-835, 2001.
11. Zhuang L, Kim J, Adam RM, Solomon KR and Freeman MR: Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest 115: 959-968, 2005.
12. Sleijfer S: Bleomycin-induced pneumonitis. Chest 120: 617-624, 2001.
13. Schulze E, Witt M, Kasper M, Lowik CW and Funk RH: Immunohistochemical investigations on the differentiation marker protein E11 in rat calvaria, calvaria cell culture and the osteoblastic cell line ROS 17/2.8. Histochem Cell Biol 111: 61-69., 1999.
14. Nakanishi K, Maruyama M, Shibata T and Morishima N: Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development. J Biol Chem 276: 41237-41244, 2001.
15. Kasper M, Roehlecke C, Witt M, Fehrenbach H, Hofer A, Miyata T, Weigert C, Funk RH and Schleicher ED: Induction of apoptosis by glyoxal in human embryonic lung epithelial cell line L132. Am J Respir Cell Mol Biol 23: 485-491, 2000.
16. Song KS, Li S, Okamoto T, Quilliam LA, Sargiacomo M and Lisanti MP: Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem 271: 9690-9697, 1996.
17. Ramaekers FC, Haag D, Kant A, Moesker O, Jap PH and Vooijs GP: Coexpression of keratin- and vimentin-type intermediate filaments in human metastatic carcinoma cells. Proc Natl Acad Sci USA 80: 2618-2622, 1983.
18. Li X, Zhang H, Soledad-Conrad V, Zhuang J and Uhal BD: Bleomycin-induced apoptosis of alveolar epithelial cells requires angiotensin synthesis de novo. Am J Physiol Lung Cell Mol Physiol 284: L501-507, 2003.
19. Riedl SJ, Li W, Chao Y, Schwarzenbacher R and Shi Y: Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature 434: 926-933, 2005.
20. Barth K, Gentsch M, Blasche R, Pfuller A, Parshyna I, Koslowski R, Barth G and Kasper M: Distribution of caveolin-1 and connexin43 in normal and injured alveolar epithelial R3/1 cells. Histochem Cell Biol 123: 239-247, 2005.
21. Koslowski R, Fichtner F, Barth K, Roehlecke C, Seidel D and Kasper M: Apoptosis and release of CD44s in bleomycin-treated L132 cells. J Cell Biochem 95: 1146-1156, 2005.
22. Kagan VE, Borisenko GG, Serinkan BF, Tyurina YY, Tyurin VA, Jiang J, Liu SX, Shvedova AA, Fabisiak JP, Uthaisang W and Fadeel B: Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine. Am J Physiol Lung Cell Mol Physiol 285: L1-17, 2003.
23. Roussel E, Belanger MM and Couet J: G2/M blockade by paclitaxel induces caveolin-1 expression in A549 lung cancer cells: caveolin-1 as a marker of cytotoxicity. Anticancer Drugs 15: 961-967, 2004.
24. Gargalovic P and Dory L: Cellular apoptosis is associated with increased caveolin-1 expression in macrophages. J Lipid Res 44: 1622-1632, 2003.
25. Cho KA, Ryu SJ, Oh YS, Park JH, Lee JW, Kim HP, Kim KT, Jang IS and Park SC: Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem 279: 42270-42278, 2004.
26. Aoshiba K, Tsuji T and Nagai A: Bleomycin induces cellular senescence in alveolar epithelial cells. Eur Respir J 22: 436-443, 2003.
27. Cloos J, Temmink O, Ceelen M, Snel MH, Leemans CR and Braakhuis BJ: Involvement of cell cycle control in bleomycin-induced mutagen sensitivity. Environ Mol Mutagen 40: 79-84, 2002.
28. Torres VA, Tapia JC, Rodriguez DA, Parraga M, Lisboa P, Montoya M, Leyton L and Quest AF: Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin. J Cell Sci 119: 1812-1823, 2006.
29. Wheaton K, Sampsel K, Boisvert FM, Davy A, Robbins S and Riabowol K: Loss of functional caveolae during senescence of human fibroblasts. J Cell Physiol 187: 226-235, 2001.