Upregulation of nitric oxide, inhibition of oxidative stress, and antihypertensive effects of statins [7]

Hypertension

Volumn 49, Issue 6, 2007, Pages

  Zhou, Ming Sheng ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ATORVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPROSTANE; OXIDOREDUCTASE INHIBITOR; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANTIHYPERTENSIVE ACTIVITY; AORTA INJURY; CLINICAL TRIAL; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HEART LEFT VENTRICLE HYPERTROPHY; HEMODYNAMIC STRESS; HUMAN; HYPERTENSION; LETTER; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; SYSTOLIC BLOOD PRESSURE; UPREGULATION; VASODILATATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION; NITRIC OXIDE; OXIDATIVE STRESS; PYRROLES; RATS; RATS, INBRED DAHL; REACTIVE OXYGEN SPECIES; UP-REGULATION; VASOCONSTRICTION;

EID: 34249281313     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.090159     Document Type: Letter

References (5)

1. Strazzullo P, Kerry SM, Barbato A, Versiero M, D'Elia L, Cappuccio FP. Do statins reduce blood pressure? A meta-analysis of randomized, controlled trials. Hypertension. 2007;49:792-798.
2. Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, Sanchez-Pascuala R, Hernandez G, Diaz C, Lamas S. Effects of the 3-hydroxy-3-methylglutaryl- coenzymeA (CoA) reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest. 1998;101:2711-2719.
3. Zhou MS, Jaimes EA, Raij L. Atorvastatin prevents end-organ injury in salt-sensitive hypertension-role of eNOS and oxidant stress. Hypertension. 2004;44:186-190.
4. Zhou MS, Schulman IH, Pagano PJ, Jaimes EA, Raij L. Reduced NAD(P)H oxidase in low renin hypertension-link among angiotensin II, atherogenesis, and blood pressure. Hypertension. 2006;47:81-86.
5. Zhou MS, Adam AG, Jaimes EA, Raij L. In salt-sensitive hypertension, increased superoxide production is linked to functional upregulation of angiotensin II. Hypertension. 2003;42:945-951.