High serum levels of B-lymphocyte stimulator are associated with clinical-pathological features and outcome in classical Hodgkin lymphoma

British Journal of Haematology

Volumn 137, Issue 6, 2007, Pages 553-559

  Tecchio, C ^a   Nadali, G ^a   Scapini, P ^a   Bonetto, C ^a   Visco, C ^b   Tamassia, N ^a   Vassilakopoulos, T P ^c   Pangalis, G A ^c   Calzetti, F ^a   Nardelli, B ^d   Roschke, V ^d   Gottardi, M ^e   Zampieri, F ^a   Gherlinzoni, F ^e   Facchetti, F ^f   Pizzolo, G ^a   Cassatella, M A ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b SAN BORTOLO HOSPITAL   (Italy)

^c UNIVERSITY OF ATHENS   (Greece)

^d GLAXOSMITHKLINE   (United States)

^e Regional Hospital C Foncello   (Italy)

^f SPEDALI CIVILI   (Italy)

Author keywords

B lymphocyte stimulator; Hodgkin lymphoma

Indexed keywords

B LYMPHOCYTE STIMULATOR PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; B LYMPHOCYTE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DONOR; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GROUPS BY AGE; HODGKIN DISEASE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; SERUM; SOLUBILITY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; UPREGULATION;

ADOLESCENT; ADULT; AGED; B-CELL ACTIVATING FACTOR; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HODGKIN DISEASE; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 34249279816     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2007.06615.x     Document Type: Article

References (28)

1. Briones, J., Timmerman, J.M., Hilbert, D.M. Levy, R. (2002) BLyS and BLyS receptor expression in non-Hodgkin's lymphomas. Experimental Hematology, 30, 135 141.
2. Byrd, J.C. (2004) BAFF and related proteins: a new therapeutic target for B-cell malignancies. Blood, 103, 372 373.
3. Chang, S.K., Arendt, B.K., Darce, J.R., Wu, X. Jelinek, D.F. (2006) A role for BLyS in the activation of innate immune cells. Blood, 108, 2687 2694.
4. Chiu, A., Xu, W., He, B., Dillon, S.R., Gross, J.A., Sievers, E., Qiao, X., Santini, P., Hyjek, E., Lee, J.W., Cesarman, E., Chadburn, A., Knowles, D.M. Cerutti, A. (2007) Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood, 109, 729 739.
5. Dillon, S.R., Gross, J.A., Ansell, S.M. Novak, A.J. (2006) An APRIL to remember: novel TNF ligands as therapeutic targets. Nature Reviews, 5, 235 246.
6. Elsawa, S.F., Novak, A.J., Grote, D.M., Ziesmer, S.C., Witzig, T.E., Kyle, R.A., Dillon, S.R., Harder, B., Gross, J.A. Ansell, S.M. (2006) B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom's macroglobulinemia. Blood, 107, 2882 2888.
7. Hasenclaver, D. Diehl, V. (1998) A prognostic score for advanced Hodgkin's disease. International Prognostic Factors Project on Advanced Hodgkin's Disease. New England Journal of Medicine, 339, 1506 1514.
8. He, B., Raab-Traub, N., Casali, P. Cerruti, A. (2003) EBV-encoded latent membrane Protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching. Journal of Immunology, 171, 5215 5224.
9. He, B., Chadburn, A., Jou, E., Schattner, E.J., Knowles, D.M. Cerruti, A. (2004) Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL. Journal of Immunology, 172, 3268 3279.
10. Kaplan, E.L. Meier, P. (1958) Non-parametric estimation from incomplete observations. Journal of the American Statistical Association, 53, 257 481.
11. Kern, C., Cornuel, J., Billard, C., Tang, R., Rouillard, D., Stenou, V., Defrance, T., Ajchenbaum-Cymbalista, F., Simonin, P., Feldblum, S. Kolb, J. (2004) Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. Blood, 103, 679 688.
12. Kuppers, R., Schwering, I., Brauninger, A., Rajewsky, K. Hansmann, M.L. (2002) Biology of Hodgkin's lymphoma. Annals of Oncology, 13 (Suppl. 1 11 18.
13. Lister, T.A., Crowther, D., Sutcliffe, S.B., Glatstein, E., Canellos, G.P., Young, R.C., Rosenberg, S.A., Coltman, C.A. Tubiana, M. (1989) Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswold meeting. Journal of Clinical Oncology, 7, 1630 1636.
14. Maggio, E., Van den Berg, A., Diepstra, A., Kluiver, J., Visser, L. Poppema, S. (2002) Chemokines, cytokines and their receptors in Hodgkin's lymphoma cell lines and tissues. Annals of Oncology, 13, 52 56.
15. Mantel, N. (1966) Evaluation of survival data and the two new rank order statistics arising in its consideration. Cancer Chemotherapy Reports, 50, 163 170.
16. Moore, P.A., Belvedere, O., Orr, A., Pieri, K., LaFleur, D.W., Feng, P., Soppet, D., Charters, M., Gentz, R., Parmelee, D., Li, Y., Galperina, O., Giri, J., Roschke, V., Nardelli, B., Carrell, J., Sosnovtseva, S., Greenfield, W., Ruben, S.M., Olsen, H.S., Fikes, J. Hilbert, D.M. (1999) BlyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science, 285, 260 263.
17. Moreaux, J., Legouffe, E., Jourdan, E., Quittet, P., Reme, T., Lugagne, C., Moine, P., Rossi, J., Klein, B. Tarte, K. (2004) BAFF and APRIL protect myeloma cells from apoptosis induced by IL-6 deprivation and dexamethasone. Blood, 103, 3148 3157.
18. Nardelli, B., Belvedere, O., Roschke, V., Moore, P.A., Olsen, H.S., Migone, T.S., Sosnovtseva, S., Carrell, J.A., Feng, P., Giri, J.G. Hilbert, D.M. (2001) Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood, 97, 198 204.
19. Novak, A.J., Bram, R.J., Kay, N.E. Jelinak, D.F. (2002) Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukaemia cells: a mechanism for survival. Blood, 100, 2973 2979.
20. Novak, A.J., Darce, J.R., Arendt, B.K., Harder, B., Henderson, K., Kindsvogel, W., Gross, J.A., Greipp, P.R. Jelinek, D.F. (2004a) Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood, 103, 689 694.
21. Novak, A., Grote, D.M., Stenson, M., Ziesmer, S.C., Witzig, T.E., Habermann, T.M, Harder, B., Ristow, K.M., Bram, R.J., Jelinek, D.F., Gross, J.A Ansell, S.M. (2004b) Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome. Blood, 104, 2247 2253.
22. Roschke, V., Sosnovtseva, S., Ward, C.D., Hong, J.S., Smith, R., Albert, V., Stohl, W., Baker, K.P., Ullrich, S., Nardelli, B., Hilbert, D.M. Migone, T.S. (2002) BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. Journal of Immunology, 169, 4314 4321.
23. Rossi, J., Borghini-Fuhrer, I., Moreaux, J., Requirand, G., Bouseida, S., Picard, M., Ythier, A., Sievers, E. Klein, B. (2005) A phase I/II study of TACI-Ig to neutralize APRIL and BLyS in patients with refractory or relapsed multiple myeloma or active previously treated Waldenstrom's macroglobulinemia. Blood, 106, Abstract 2566.
24. Scapini, P., Nardelli, B., Nadali, G., Calzetti, F., Pizzolo, G., Montecucco, C. Cassatella, M.A. (2003) G-CSF-stimulated neutrophils are a prominent source of functionally BLyS. Journal of Experimental Medicine, 197, 297 302.
25. Scapini, P., Carletto, A., Nardelli, B., Calzetti, F., Roschke, V., Merigo, F., Tamassia, N., Pieropan, S., Biasi, D., Sbarbati, A., Sozzani, S., Bambara, L. Cassatella, M.A. (2005) Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases. Blood, 105, 830 837.
26. Schwering, I., Brauninger, A., Klein, U., Jungnickel, B., Tinguely, M., Diehl, V., Hansmann, M.L., Dalla-Favera, R., Rajewsky, K. Kuppers, R. (2003) Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood, 101, 1505 1512.
27. Skinnider, B.F. Mak, T.W. (2002) The role of cytokines in classical Hodgkin lymphoma. Blood, 99, 4283 4297.
28. Visco, C., Vassilakopoulos, T.P., Kliche, K.O., Nadali, G., Viviani, S., Bonfante, V., Medeiros, L.J., Notti, P., Rassidakis, G.Z., Peethambaram, P., Wilder, R., Witzig, T., Gianni, M., Bonadonna, G., Pizzolo, G., Pangalis, G.A., Cabanillas, F. Sarris, A.H. (2004) Elevated serum levels of IL-10 are associated with inferior progression-free survival in patients with Hodgkin's disease treated with radiotherapy. Leukemia & Lymphoma, 45, 2085 2092.