Activity of the β-myosin heavy chain antisense promoter responds to diabetes and hypothyroidism

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 6, 2007, Pages

  Giger, Julia ^a   Qin, Anqi X ^a   Bodell, Paul W ^a   Baldwin, Kenneth M ^a   Haddad, Fadia ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hyperthyroidism; In vivo gene injection; mRNA; Peroxisome proliferator activated receptor; Retinoic acid receptor

Indexed keywords

COMPLEMENTARY RNA; LUCIFERASE; MYOSIN HEAVY CHAIN BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PLASMID VECTOR; PROPYLTHIOURACIL; RETINOIC ACID RECEPTOR; STREPTOZOCIN; THYROID HORMONE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTISENSE THERAPY; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; HYPERTHYROIDISM; HYPOTHYROIDISM; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; STREPTOZOCIN DIABETES; TANDEM REPEAT; TRANSCRIPTION REGULATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DNA, INTERGENIC; FEMALE; GENES, REPORTER; HEART VENTRICLES; HYPERTHYROIDISM; HYPOTHYROIDISM; LUCIFERASES; MUTATION; MYOSIN HEAVY CHAINS; PROMOTER REGIONS (GENETICS); PROPYLTHIOURACIL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS; RNA; RNA PRECURSORS; RNA, ANTISENSE; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRIIODOTHYRONINE; VENTRICULAR MYOSINS;

EID: 34249275013     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01224.2006     Document Type: Article

References (37)

1. Brandt JM, Djouadi F, Kelly DP. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor-α. J Biol Chem 273: 23786-23792, 1998.
2. Brantl S. Antisense-RNA regulation and RNA interference. Biochim Biophys Acta 1575: 15-25, 2002.
3. Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology 146: 5341-5349, 2005.
4. D'Alessio AC, Szyf M. Epigenetic tete-a-tete: the bilateral relationship between chromatin modifications and DNA methylation. Biochem Cell Biol 84: 463-476, 2006.
5. Danzi S, Klein I. Posttransciptional regulation of myosin heavy chain expression in the heart by triiodothyronine. Am J Physiol Heart Circ Physiol 288: H455-H460, 2005.
6. Danzi S, Ojamaa K, Klein I. Triiodothyronine-mediated myosin heavy chain gene transcription in the heart. Am J Physiol Heart Circ Physiol 284: H2255-H2262, 2003.
7. Direnzo J, Soderstrom M, Kurokawa R, Ogliastro MH, Ricote M, Ingrey S, Horlein A, Rosenfeld MG, Glass CK. Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors. Mol Cell Biol 17: 2166-2176, 1997.
8. Edwards JG, Bahl JJ, Flink IL, Cheng SY, Morkin E. Thyroid hormone influences beta myosin heavy chain (βMHC) expression. Biochem Biophys Res Commun 199: 1482-1488, 1994.
9. Everett AW, Clark WA, Chizzonite RA, Zak R. Change in synthesis rates of α- and β-myosin heavy chains in rabbit heart after treatment with thyroid hormone. J Biol Chem 258: 2421-2425, 1983.
10. Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW, Kelly DP. A critial role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci USA 100: 1226-1231, 2003.
11. Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk GD, Kelly DP. The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus. J Clin Invest 109: 121-130, 2002.
12. Giger J, Haddad F, Qin A, Baldwin KM. Functional overload increases beta-MHC promoter activity in rodent fast muscle via the proximal MCAT (βe3) site. Am J Physiol Cell Physiol 282: C518-C527, 2002.
13. Giger J, Haddad F, Qin A, Baldwin KM. Effect of cyclosporin A treatment on the in vivo regulation of type I MHC gene expression. J Appl Physiol 97: 475-483, 2004.
14. Giger J, Haddad F, Qin AX, Zeng M, Baldwin KM. The effect of unloading on type I MHC gene regulation in rat soleus muscle. J Appl Physiol 98: 1185-1194, 2005.
15. Green NK, Franklyn JA, Ahlquist JAO, Gammage MD, Sheppard MC. Differential regulation by thyroid-hormones of myosin heavy-chain alpha-messenger RNA and beta-messenger RNA in the rat ventricular myocardium. J Endocrinol 122: 193-200, 1989.
16. Haddad F, Bodell P, McCue SA, Baldwin KM. Effects of diabetes on rodent cardiac thyroid hormone receptor and isomyosin expression. Am J Physiol Endocrinol Metab 272: E856-E863, 1997.
17. Haddad F, Bodell P, Qin A, Giger J, Baldwin KM. Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching. J Biol Chem 278: 37132-37138, 2003.
18. Haddad F, Qin AX, Bodell PW, Zhang LY, Guo H, Giger JM, Baldwin KM. Regulation of antisense RNA expression during cardiac MHC gene switching in response to pressure overload. Am J Physiol Heart Circ Physiol 290: H2351-H2361, 2006.
19. Hasenfuss G, Mulieri LA, Blanchard EM, Holubarsch C, Leavitt BJ, Ittleman F, Alpert NR. Energetics of isometric force development in control and volume-overload human myocardium. Comparison with animal species. Circ Res 68: 836-846, 1991.
20. Huang WY, Liew CC. A conserved GATA motif in a tissue-specific DNase I hypersensitive site of the cardiac alpha-myosin heavy chain gene. Biochem J 325: 47-51, 1997.
21. Lavorgna G, Dahary D, Lehner B, Sorek R, Sanderson CM, Casari G. In search of antisense. Trends Biochem Sci 29: 88-94, 2004.
22. Lee S, Privalsky ML. Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties. Mol Endocrinol 19: 863-878, 2005.
23. Mahdavi V, Chambers AP, Nadal-Ginard B. Cardiac α- and β-myosin heavy chain genes are organized in tandem. Proc Natl Acad Sci USA 81: 2626-2630, 1984.
24. Morkin E. Control of cardiac myosin heavy chain gene expression. Microsc Res Tech 50: 522-531, 2000.
25. Nadal-Ginard B, Mahdavi V. Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches. J Clin Invest 84: 1693-1700, 1989.
26. Ojamaa K, Klein I. Thyroid hormone regulation of alpha-myosin heavy chain promoter activity assessed by in vivo DNA transfer in rat heart. Biochem Biophys Res Commun 179: 1269-1275, 1991.
27. Ojamaa K, Klemperer JD, MacGilbray SS, Klein I, Samarel AM. Thyroid hormone and hemodynamic regulation of β-myosin heavy chain promoter in the heart. Endocrinology 137: 802-808, 1996.
28. Ramanathan T, Shirota K, Morita S, Nishimura T, Huang Y, Zheng X, Hunyor S. Left ventricular oxygen utilization efficiency is impaired in chronic streptozotocin-diabetic sheep. Cardiovasc Res 55: 749-756, 2002.
29. Razeghi P, Young ME, Cockrill TC, Frazier OH, Taegtmeyer H. Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure. Circulation 106: 407-411, 2002.
30. Rindt H, Subramaniam A, Robbins J. An in vivo analsis of transcriptional elements in the mouse α-myosin heavy chain gene promoter. Transgenic Res 4: 397-405, 1995.
31. Rundell VLM, Geenen DL, Buttrick PM, de Tombe PP. Depressed cardiac tension cost in experimental diabetes is due to altered myosin heavy chain isoform expression. Am J Physiol Heart Circ Physiol 287: H408-H413, 2004.
32. Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K. Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation 107: 3040-3046, 2003.
33. Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev 76: 371-423, 1996.
34. Swoap SJ, Haddad F, Bodell P, Baldwin KM. Control of β-myosin heavy chain expression in systemic hypertension and caloric restriction in the rat heart. Am J Physiol Cell Physiol 269: C1025-C1033, 1995.
35. Tufarelli C. The silence RNA keeps: cis mechanisms of RNA mediated epigenetic silencing in mammals. Philos Trans R Soc Lond B Biol Sci 361: 67-79, 2006.
36. Wright CE, Bodell PW, Haddad F, Qin A, Baldwin KM. In vivo regulation of the β-myosin heavy chain gene in hypertensive rodent heart. Am J Physiol Cell Physiol 280: C1262-C1276, 2001.
37. Wright CE, Haddad F, Bodell PW, Baldwin KM. In vivo regulation of the β-myosin heavy chain gene in rodent heart: role of thyroid hormone and evidence for an upstream enhancer. Am J Physiol Cell Physiol 276: C883-C891, 1999.