In vivo regulation of β-MHC gene in rodent heart: Role of T3 and evidence for an upstream enhancer

American Journal of Physiology - Cell Physiology

Volumn 276, Issue 4 45-4, 1999, Pages

  Wright, Carola E ^a   Haddad, F ^a   Qin, A X ^a   Bodell, P W ^a   Baldwin, K M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dual luciferase; In vivo gene transfer; Thyroid response element; Transcription; myosin heavy chain

Indexed keywords

LIOTHYRONINE; LUCIFERASE; MYOSIN HEAVY CHAIN; THYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENHANCER REGION; FEMALE; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE FUSION; GENE TRANSFER; GENETIC TRANSFECTION; HEART; HORMONAL REGULATION; HORMONE RESPONSIVE ELEMENT; HYPERTHYROIDISM; HYPOTHYROIDISM; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; TRANSCRIPTION REGULATION;

ANIMALIA; RENILLA; RENILLA LUCIFERASE; RODENTIA; TRIXIS;

EID: 0032900327     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1999.276.4.c883     Document Type: Article

References (11)

1. Baldwin, K. M. Effects of chronic exercise on biochemical and functional properties of the heart. Med. Sci. Sports Exerc. 17: 522-528, 1985.
2. Blackwood, E. M., and J. T. Kadonaga. Going the distance: a current view of enhancer action. Science 281: 61-63, 1998.
3. Boheler, K. R., C. Chassagne, X. Martin, C. Wisnewsky, and K. Schwartz. Cardiac expressions of α- and β-myosin heavy chains and sarcomeric α-actins are regulated through transcriptional mechanisms. Results from nuclear run-on assays in isolated rat cardiac nuclei. J. Biol. Chem. 267: 12979-12985, 1992.
4. Brent, G. A., J. W. Harney, Y. Chen, R. L. Warne, D. D. Moore, and P. R. Larsen. Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. Mol. Endocrinol. 3: 1996-2004, 1989.
5. Buttrick, P. M., M. L. Kaplan, R. N. Kitsis, and L. A. Leinwand. Distinct behavior of cardiac myosin heavy chain gene constructs in vivo. Discordance with in vitro results. Circ. Res. 72: 1211-1217, 1993.
6. Buttrick, P. M., A. Kass, R. N. Kitsis, M. L. Kaplan, and L. A. Leinwand. Behavior of genes directly injected into the rat heart in vivo. Circ. Res. 70: 193-198, 1992.
7. Carr, F. E., J. Burnside, and W. W. Chin. Thyroid hormones regulate rat thyrotropin-β gene promoter activity expressed in GH3 cells. Mol. Endocrinol 3: 709-716, 1989.
8. Carr, F. E., and N. C. Wong. Characteristics of a negative thyroid hormone response element. J. Biol. Chem. 269: 4175-4179, 1994.
9. Chatterjee, V. K., J. K. Lee, A. Rentoumis, and J. L. Jameson. Negative regulation of the thyroid-stimulating hormone-α gene by thyroid hormone: receptor interaction adjacent to the TATA box. Proc. Natl. Acad. Sci. USA 86: 9114-9118, 1989.
10. Edwards, J. G., J. J. Bahl, S. Y. Cheng, and E. Morkin. Thyroid hormone influences β-myosin heavy chain expression. Biochem. Biophys. Res. Commun. 199: 1482-1488, 1994.
11. Edwards, J. G., J. J. Bahl, I. Flink, J. Milavetz, S. Goldman, and E. Morkin. A repressor region in the human β-myosin heavy chain gene that has a partial position dependency. Biochem. Biophys. Res. Commun. 189: 504-510, 1992.