Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists

Pharmaceutical Research

Volumn 24, Issue 6, 2007, Pages 1138-1144

  Gong, Yuping ^a   Zhao, Zhiyang ^b,c   McConn, Donavon J ^b   Beaudet, Beth ^b   Tallman, Melanie ^d   Speake, Jason D ^b   Ignar, Diane M ^b   Krise, Jeffrey P ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b GLAXOSMITHKLINE   (United States)

^c AMGEN INC   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cell fractionation; Lysosomes; pH partitioning; Pharmacokinetics

Indexed keywords

GSK 045A; GSK 047A; GSK 171B; HORMONE RECEPTOR STIMULATING AGENT; MELANOCORTIN 4 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL FRACTIONATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RETENTION; ENZYME ASSAY; LIVER; LIVER LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; LIVER; LYSOSOMES; MICE; PHARMACOKINETICS; RECEPTOR, MELANOCORTIN, TYPE 4;

EID: 34249074813     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9239-y     Document Type: Article

References (15)

1. K. Yokogawa, J. Ishizaki, S. Ohkuma, and K. Miyamoto. Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model. Methods Find. Exp. Clin. Pharmacol. 24:81-93 (2002).
2. M. Duvvuri, W. Feng, A. Mathis, and J. P. Krise. A cell fractionation approach for the quantitative analysis of subcellular drug disposition. Pharm. Res. 21:26-32 (2004).
3. M. Duvvuri and J. P. Krise. A novel assay reveals that weakly basic model compounds concentrate in lysosomes to an extent greater than pH-partitioning theory would predict. Mol. Pharm. 2:440-448 (2005).
4. Y. Gong, M. Duvvuri, and J. P. Krise. Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60. J. Biol. Chem. 278:50234-50239 (2003).
5. W. A. Daniel and J. Wojcikowski. Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs. Pharmacol. Toxicol. 80:62-68 (1997).
6. J. Ishizaki, K. Yokogawa, F. Ichimura, and S. Ohkuma. Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs. J. Pharmacol. Exp. Ther. 294:1088-1098 (2000).
7. R. Safaei, K. Katano, B. J. Larson, G. Samimi, A. K. Holzer, W. Naerdemann, M. Tomioka, M. Goodman, and S. B. Howell. Intracellular localization and trafficking of fluorescein-labeled cisplatin in human ovarian carcinoma cells. Clin. Cancer Res. 11:756-767 (2005).
8. R. M. Sandoval and B. A. Molitoris. Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum. Am. J. Physiol. Renal. Physiol. 286:F617-624 (2004).
9. C. de Duve, T. de Barsy, B. Poole, A. Trouet, P. Tulkens, and F. Van Hoof. Commentary. Lysosomotropic agents. Biochem. Pharmacol. 23:2495-2531 (1974).
10. K. Tanigaki, S. Sasaki, and S. Ohkuma. In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis. FEBS Lett. 537:79-84 (2003).
11. M. Schindler, S. Grabski, E. Hoff, and S. M. Simon. Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr). Biochemistry 35:2811-2817 (1996).
12. M. Duvvuri, S. Konkar, R. S. Funk, J. M. Krise, and J. P. Krise. A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells. Biochemistry 44:15743-15749 (2005).
13. M. Duvvuri, Y. Gong, D. Chatterji, and J. P. Krise. Weak base permeability characteristics influence the intracellular sequestration site in the multidrug-resistant human leukemic cell line HL-60. J. Biol. Chem. 279:32367-32372 (2004).
14. K. Shedden, X. T. Xie, P. Chandaroy, Y. T. Chang, and G. R. Rosania. Expulsion of small molecules in vesicles shed by cancer cells: association with gene expression and chemosensitivity profiles. Cancer Res. 63:4331-4337 (2003).
15. M. Duvvuri, S. V. Konkar, K. H. Hong, B. S. J. Blagg, and J. P. Krise. A new approach for enhancing differential selectivity of drugs to cancer cells. Chem. Biol. 1:309-315 (2006).