Amyotrophic lateral sclerosis with dementia showing clinical parkinsonism and severe degeneration of the substantia nigra: Report of an autopsy case

Neuropathology

Volumn 27, Issue 3, 2007, Pages 295-299

  Shintaku, Masayuki ^a   Oyanagi, Kiyomitsu ^b   Kaneda, Daita ^a  

^a OSAKA RED CROSS HOSPITAL   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Amyotrophic lateral sclerosis with dementia; Degeneration; Mineralization; Parkinsonism; Substantia nigra

Indexed keywords

ALPHA SYNUCLEIN; CABERGOLINE; LEVODOPA;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPSY; CASE REPORT; CELL INCLUSION; DEMENTIA; DISEASE SEVERITY; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; MINERALIZATION; MOTOR NEURON DISEASE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL; SPINAL CORD VENTRAL HORN; SUBSTANTIA NIGRA; TEMPORAL CORTEX;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; AUTOPSY; DEMENTIA; DIAGNOSIS, DIFFERENTIAL; DOPAMINE AGENTS; FATAL OUTCOME; HUMANS; LEVODOPA; MAGNETIC RESONANCE IMAGING; MALE; PARKINSON DISEASE; PARKINSONIAN DISORDERS; SUBSTANTIA NIGRA;

EID: 34249048839     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2007.00763.x     Document Type: Article

References (22)

1. Horoupian DS, Thal L, Katzman R et al. Dementia and motor neuron disease. Morphometric, biochemical, and Golgi studies. Ann Neurol 1984 16 : 305 13.
2. Kato S, Oda M, Tanabe H. Diminution of dopaminergic neurons in the substantia nigra of sporadic amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol 1993 19 : 300 4.
3. Tsuchiya K, Ikeda K, Mimura M et al. Constant involvement of the Betz cells and pyramidal tract in amyotrophic lateral sclerosis with dementia. A clinicopathological study of eight autopsy cases. Acta Neuropathol 2002 104 : 249 59.
4. Al-Sarraj S, Maekawa S, Kibble M, Everall I, Leigh N. Ubiquitin-only intraneuronal inclusion in the substantia nigra is a characteristic feature of motor neurone disease with dementia. Neuropathol Appl Neurobiol 2002 28 : 120 8.
5. Mackenzie IR, Feldman H. Extrapyramidal features in patients with motor neuron disease and dementia. A clinicopathological correlative study. Acta Neuropathol 2004 107 : 336 40.
6. Yoshida M. Amyotrophic lateral sclerosis with dementia. The clinicopathological spectrum. Neuropathology 2004 24 : 87 102.
7. Mitsuyama Y. Presenile dementia with motor neuron disease in Japan. Clinico-pathological review of 26 cases. J Neurol Neurosurg Psychiatry 1984 47 : 953 9.
8. Hudson AJ. Amyotrophic lateral sclerosis and its association with dementia, parkinsonism and other neurological disorders. A review. Brain 1981 104 : 217 47.
9. Yuasa R. Amyotrophic lateral sclerosis with dementia. Clin Neurol (Tokyo) 1970 10 : 569 77 (in Japanese with English abstract).
10. Nakano I, Iwatsubo T, Hashizume Y, Mizutani T, Mannen T. Amyotrophic lateral sclerosis with dementia. Lesions in the apical cortex and some deeper structures of the temporal lobes. Neuropathology 1992 12 : 69 77.
11. Mackenzie IRA, Feldman HH. Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum. J Neuropathol Exp Neurol 2005 64 : 730 9.
12. Okamoto K, Hirai S, Yamazaki T, Sun X, Nakazato Y. New ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with amyotrophic lateral sclerosis. Neurosci Lett 1991 129 : 233 6.
13. Jackson M, Lennox G, Lowe J. Motor neuron disease-inclusion dementia. Neurodegeneration 1996 5 : 339 50.
14. Sudo S, Fukutani Y, Matsubara R et al. Motor neuron disease with dementia combined with degeneration of striatonigral and pallidoluysian systems. Acta Neuropathol 2002 103 : 521 2.
15. Toyoshima Y, Tan CF, Kozakai T, Tanaka M, Takahashi H. Is motor neuron disease-inclusion dementia a forme fruste of amyotrophic lateral sclerosis with dementia? An autopsy case further supporting the disease concept. Neuropathology 2005 25 : 214 19.
16. Oyanagi K, Nakashima S, Ikuta F, Homma Y. An autopsy case of dementia and parkinsonism with severe degeneration exclusively in the substantia nigra. Acta Neuropathol 1986 70 : 190 2.
17. Rajput AH, Uitti RJ, Sudhakar S, Rozdilsky B. Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei. Ann Neurol 1989 25 : 602 6.
18. Ishihara K, Nonaka A, Fukui T, Kawamura M, Shiota J, Nakano I. Lewy body-free nigral degeneration. A case report. J Neurol Sci 2002 198 : 97 100.
19. Itoh H, Nakamura S, Akiguchi I, Yamao S, Kameyama M. Levodopa therapy for a patient with ALS-dementia complex. Clin Neurol (Tokyo) 1987 27 : 1145 9 (in Japanese with English abstract).
20. Inoue K, Hirano A. Early pathological changes of amyotrophic lateral sclerosis. Autopsy findings of a case of 10 months' duration. Clin Neurol (Tokyo) 1979 11 : 448 55 (in Japanese with English abstract).
21. Tsuchiya K, Takahashi M, Shiotsu H et al. Sporadic amyotrophic lateral sclerosis with circumscribed temporal atrophy. A report of an autopsy case without dementia and with ubiquitinated intraneuronal inclusions. Neuropathology 2002 22 : 308 16.
22. Ota S, Tsuchiya K, Akiyama H. "Forme fruste" of amyotrophic lateral sclerosis with dementia. A report of five autopsy cases without dementia and with ubiquitinated intraneuronal inclusions. Neuropathology 2005 25 : 326 35.