Effects of impaired testosterone metabolism during prenatal ontogenesis on the level of anxiety and behavior of rats in a novel environment

Neuroscience and Behavioral Physiology

Volumn 37, Issue 5, 2007, Pages 435-441

  Ordyan, N E ^a   Pivina, S G ^a   Akulova, V K ^a  

^a PAVLOV INSTITUTE OF PHYSIOLOGY   (Russian Federation)

Author keywords

Anxiety; Behavior in a novel environment; Elevated cross maze test; Gender differences; Open field test; Prenatal administration of ATD; Rats

Indexed keywords

ANDROSTA 1,4,6 TRIENE 3,17 DIONE; TESTOSTERONE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; AROMATIZATION; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; EMOTIONALITY; ENVIRONMENTAL FACTOR; FEMALE; GENDER BIAS; GROOMING; IMMOBILIZATION; MALE; MAZE TEST; MOTOR PERFORMANCE; NONHUMAN; ONTOGENY; OPEN FIELD TEST; PRENATAL DEVELOPMENT; RAT; TESTOSTERONE METABOLISM; THIRD TRIMESTER PREGNANCY;

ANDROSTATRIENES; ANIMALS; ANXIETY; AROMATASE INHIBITORS; BRAIN; EMOTIONS; EXPLORATORY BEHAVIOR; FEMALE; MALE; ORGANOGENESIS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; SEX DIFFERENTIATION; SEX FACTORS; TESTOSTERONE;

EID: 34249041485     PISSN: 00970549     EISSN: 1573899X     Source Type: Journal    
DOI: 10.1007/s11055-007-0032-5     Document Type: Article

References (22)

1. E. P. Vinogradova, O. N. Polyakova, and A. S. Batuev, "Effects of prenatal 'pain' and 'emotional' stresses on the characteristics of learning in rats," Zh. Vyssh. Nerv. Deyat., 46, No. 6, 1097-1103 (1996).
2. N.́E. Ordyan and S. G. Pivina, "Characteristics of behavior and stress reactivity of the hypophyseal-adrenocortical system in prenatally stressed rats," Ros. Fiziol. Zh., 84, No. 1, 52-59 (2003).
3. V. G. Shalyapina, I. N. Zaichenko, A. S. Batuev, and N.É. Ordyan, "Changes in the neuroendocrine regulation of adaptive behavior after stress during late prenatal ontogenesis," Ros. Fiziol. Zh., 87, No. 9, 1193-1201 (2001).
4. G. T. Shishkina and N. N. Dygalo, "Genes, hormones, and risk factors for the formation of the masculine phenotype," Usp. Fiziol. Nauk., 30, No. 3, 49-61 (1999).
5. S. J. Alonso, J. Arevalo, D. Afonso, and M. Rodrigues, "Effects of maternal stress during pregnancy on forced swimming test behavior of the offspring," Physiol. Behav., 50, No. 3, 511-517 (1991).
6. S. K. Amateau, J. J. Alt, C. L. Stamps, and M. M. McCarthy, "Brain estradiol content in newborn rats: Sex differences, regional heterogeneity, and possible de novo synthesis by female telencephalon," Endocrinology, 145, No. 6, 2906-2917 (2004).
7. J. Balthazart and G. E. Ball, "New insights into the regulation and function of brain estrogen synthase (aromatase)," Trends Neurosci., 21, No. 6, 243-248 (1998).
8. E. Dominguez-Salazar, W. Portillo, M. J. Baum, J. Baker, and R. G. Paredes, "Effect of prenatal androgen receptor antagonist or aromatase inhibitor on sexual behavior, partner preference and neuronal Fos responses to estrous female odors in the rat accessory olfactory system," Physiol. Behav., 75, No. 3, 337-346 (2002).
9. D. C. Gerardin and O. C. Pereira, "Reproductive changes in male rats treated perinatally with an aromatase inhibitor," Pharmacol. Biochem. Behav., 71, No. 1-2, 301-305 (2002).
10. M. I. Gonzalez and M. L. Leret, "Role of monoamines in the male differentiation of the brain induced by androgen aromatization," Pharmacol. Biochem. Behav., 41, No. 4, 733-777 (1992).
11. E. J. Houtsmuller, T. Brand, F. de Jonge, R. Joosten, N. E. van de Poll, and A. K. Slob, "SDN-POA volume, sexual behavior, and partner preference of male rats affected by perinatal treatment with AID," Physiol. Behav., 56, No. 3, 535-541 (1994).
12. N. A. Jacobson, D. R. Ladle, and E. D. Lephart, "Aromatase cytochrome P450 and 5a-reductase in the amygdala and cortex of perinatal rats," Neuroreport, 8, No. 11, 2529-2533 (1997).
13. E. Kuppers, T. Ivanova, M. Karolczak, and C. Beyer, "Estrogen: A multifunctional messenger to nigrostriatal dopaminergic neurons," Neurocytology, 29, No. 5-6, 375-385 (2000).
14. M. L. Leret, F. Molina-Holgado, and M. I. Gonzalez, "The effect of perinatal exposure to estrogens on the sexually dimorphic response to novelty," Physiol. Behav., 55, No. 2, 371-373 (1994).
15. B. S. McEwen and S. E. Alves, "Estrogen actions in central nervous system," Endocrinol. Rev., 20, No. 3, 279-307 (1999).
16. A. Poletti, P. Negri-Cesi, M. Rabuffetti, A. Colciago, F. Celotti, and L. Martini, "Transient expression of the 5alpha-reductase type 2 isozyme in the rat brain in late fetal and early postnatal life," Endocrinology, 139, No. 4, 2171-2178 (1998).
17. A. G. Reznikov, N. D. Nosenko, and L. V. Tarasenko, "Prenatal stress and glucocorticoid effects on the developing gender-related brain," J. Steroid Biochem. Mol. Biol., 69, No. 1, 109-115 (1999).
18. C. E. Rosselli and J. A. Resko, "Aromatase activity in the rat brain: Hormonal regulation and sex differences," J. Steroid Biochem. Mol. Biol., 44, No. 406, 499-508 (1993).
19. S. Segovia, A. Guillamon, M. C. R. del Cerro, E. Ortega, C. Peter-Laso, M. Rodriguez-Zafra, and C. Beyer, "The development of brain sex differences: A multisignaling process," Behav. Brain Res., 105, No. 1, 69-80 (1999).
20. R. B. Simerly, "Wired for reproduction: Organization and development of sexually dimorphic circuits in the mammalian forebrain," Ann. Rev. Neurosci., 25, 507-536 (2002).
21. F. S. vom Saal, D. M. Qadagno, M. D. Even, L. W. Keisler, D. H. Keisler, and S. Khan, "Paradoxical effects of maternal stress on fetal steroids and postnatal reproductive traits in female mice from different intrauterine position," Biol. Reprod., 43, No. 5, 751-761 (1990).
22. B. Zimmemberg and M. J. Farley, "Sex differences in anxiety behavior in rats: Role of gonadal hormones," Physiol. Behav., 54, No. 6, 1119-1124 (1993).