Localization and expression of MUC5B and MUC7 mucins in pediatric sinus mucosa

Annals of Otology, Rhinology and Laryngology

Volumn 116, Issue 5, 2007, Pages 389-397

  Peña, Maria T ^a   Aujla, Pawandeep K ^a   Zudaire, Enrique ^b   Watson, Alan M ^a   Przygodzki, Ronald ^a   Zalzal, George H ^a   Rose, Mary C ^a  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Chronic rhinosinusitis; Goblet cell; MUC5B; MUC7; Mucin; Submucosal gland

Indexed keywords

MUCIN 5B; MUCIN 7;

ARTICLE; CELL POPULATION; CELLULAR DISTRIBUTION; CHILD HEALTH CARE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GOBLET CELL; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MORPHOMETRICS; NOSE MUCOSA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RHINOSINUSITIS; SECRETORY CELL; SUBMUCOSA; TERTIARY HEALTH CARE;

EID: 34249036067     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348940711600513     Document Type: Article

References (40)

1. Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: establishing definitions for clinical research and patient care. Otolaryngol Head Neck Surg 2004;131(suppl).
2. Lusk RP, Stankiewicz JA. Pediatric rhinosinusitis. Otolaryngol Head Neck Surg 1997;117(suppl):S53-S57.
3. Parsons DS, Wald ER. Otitis media and sinusitis: similar diseases. Otolaryngol Clin North Am 1996;29:11-25.
4. Rose MC. Mucins: structure, function, and role in pulmonary diseases. Am J Physiol 1992;263:L413-L429.
5. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 2006;86:245-78.
6. Audie JP, Janin A, Porchet N, Copin MC, Gosselin B, Aubert JP. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem 1993;41:1479-85.
7. Groneberg DA, Eynott PR, Oates T, et al. Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med 2002;96:81-6.
8. Aust MR, Madsen CS, Jennings A, Kasperbauer JL, Gendler SJ. Mucin mRNA expression in normal and vasomotor inferior turbinates. Am J Rhinol 1997;11:293-302.
9. Groneberg DA, Peiser C, Dinh QT, et al. Distribution of respiratory mucin proteins in human nasal mucosa. Laryngoscope 2003;113:520-4.
10. Reid CJ, Gould S, Harris A. Developmental expression of mucin genes in the human respiratory tract. Am J Respir Cell Mol Biol 1997;17:592-8.
11. Buisine MP, Devisme L, Copin MC, et al. Developmental mucin gene expression in the human respiratory tract. Am J Respir Cell Mol Biol 1999;20:209-18.
12. Chen Y-C, Zhao YH, Di Y-P, Wu R. Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5′-flanking region. Am J Respir Cell Mol Biol 2001;25:542-53.
13. Jung HH, Lee JH, Kim YT, Lee SD, Park JH. Expression of mucin genes in chronic ethmoiditis. Am J Rhinol 2000;14:163-70.
14. Lee H-M, Kim DH, Kim JM, Lee SH, Hwang SJ. MUC8 mucin gene up-regulation in chronic rhinosinusitis. Ann Otol Rhinol Laryngol 2004;113:662-6.
15. Kim DH, Chu HS, Lee JY, Hwang SJ, Lee SH, Lee HM. Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 2004;130:747-52.
16. Peña MT, Aujla PK, Patel KM, Zalzal GH, Rose MC. Immunohistochemical analyses of MUC5AC mucin expression in sinus mucosa of children with sinusitis and controls. Ann Otol Rhinol Laryngol 2005;114:958-65.
17. Tos M, Mogensen C. Mucus production in chronic maxillary sinusitis. A quantitative histopathological study. Acta Otolaryngol (Stockh) 1984;97:151-9.
18. Sharma P, Dudus L, Nielsen PA, et al. MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways. Am J Respir Cell Mol Biol 1998;19:30-7.
19. Gandhi A, Brodsky L, Ballou M. Benefits of antibiotic prophylaxis in children with chronic sinusitis: assessment of outcome predictors. Allergy Proc 1993;14:37-43.
20. Lund VJ, Mackay IS. Staging in rhinosinusitus. Rhinology 1993;31:183-4.
21. Lund VJ, Kennedy DW. Quantification for staging sinusitis. The Staging and Therapy Group. Ann Otol Rhinol Laryngol Suppl 1995;104(suppl 167):17-21.
22. Hilleman MR, Carlson AJ Jr, McLean AA, Vella PP, Weibel RE, Woodhour AF. Streptococcus pneumoniae polysaccharide vaccine: age and dose responses, safety, persistence of antibody, revaccination, and simultaneous administration of pneumococcal and influenza vaccines. Rev Infect Dis 1981;3(suppl):S31-S42.
23. Landesman SH, Schiffman G. Assessment of the antibody response to pneumococcal vaccine in high-risk populations. Rev Infect Dis 1981;3(suppl):S184-S197.
24. Keates AC, Nunes DP, Afdhal NH, Troxler RF, Offner GD. Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem J 1997;324:295-303.
25. Liu B, Rayment S, Oppenheim FG, Troxler RF. Isolation of human salivary mucin MG2 by a novel method and characterization of its interactions with oral bacteria. Arch Biochem Biophys 1999;364:286-93.
26. Rousseau K, Wickstrom C, Whitehouse DB, Carlstedt I, Swallow DM. New monoclonal antibodies to non-glycosylated domains of the secreted mucins MUC5B and MUC7. Hydrid Hybridomics 2003;22:293-9.
27. Tos M, Mogensen C, Novotny Z. Quantitative histology of the normal ethmoidal sinus. ORL J Otorhinolaryngol Relat Spec 1978;40:172-80.
28. Goldstein NA, Jacobs JB, Lebovitz RA, Waisman J, Doniguian AE. Comparative histology of the ethmoid and maxillary sinuses in chronic sinusitis. Oper Techn Otolaryngol Head Neck Surg 1995;6:180-3.
29. Piludu M, Rayment SA, Liu B, et al. Electron microscopic immunogold localization of salivary mucins MG1 and MG2 in human submandibular and sublingual glands. J Histochem Cytochem 2003;51:69-79.
30. Bosch JA, de Geus EJ, Ligtenberg TJ, et al. Salivary MUC5B-mediated adherence (ex vivo) of Helicobacter pylori during acute stress. Psychosom Med 2000;62:40-9.
31. Prakobphol A, Levine MJ, Tabak LA, Reddy MS. Purification of a low-molecular-weight, mucin-type glycoprotein from human submandibular- sublingual saliva. Carbohydr Res 1982;108:111-22.
32. Voynow JA, Fischer BM, Roberts BC, Proia AD. Basal-like cells constitute the proliferating cell population in cystic fibrosis airways. Am J Respir Crit Care Med 2005;172:1013-8.
33. Situ H, Wei G, Smith CJ, Mashhoon S, Bobek LA. Human salivary MUC7 mucin peptides: effect of size, charge and cysteine residues on antifungal activity. Biochem J 2003;375:175-82.
34. Kirkham S, Sheehan JK, Knight D, Richardson PS, Thornton DJ. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J 2002;361:537-46.
35. Ali MS, Hutton DA, Wilson JA, Pearson JP. Major secretory mucin expression in chronic sinusitis. Otolaryngol Head Neck Surg 2005;133:423-8.
36. Shankar V, Pichan P, Eddy RL Jr, et al. Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus. Am J Respir Cell Mol Biol 1997;16:232-41.
37. Chen Y, Zhao YH, Kalaslavadi TB, et al. Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. Am J Respir Cell Mol Biol 2004;30:155-65.
38. Wake M, Takeno S, Hawke M. The early development of sino-nasal mucosa. Laryngoscope 1994;104:850-5.
39. Filali M, Liu X, Cheng N, Abbott D, Leontiev V, Engelhardt JF. Mechanisms of submucosal gland morphogenesis in the airway. Novartis Found Symp 2002;248:38-50, 277-82.
40. Rawlins EL, Hogan BL. Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. Dev Dyn 2005;233:1378-85.