Ginkgolides protect primary cortical neurons from potassium cyanide-induced hypoxic injury

Experimental Brain Research

Volumn 179, Issue 4, 2007, Pages 665-671

  Zhu, Li ^a,b   Xu, You Jia ^b   Du, Fang ^a   Qian, Zhong Ming ^a,b  

^a NANTONG UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Cell viability; Cellular morphology; Ginkgolides; LDH (lactate dehydrogenase); Neuroprotection; Neurotoxicity; Potassium cyanide (KCN); Primary cortical neurons

Indexed keywords

GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C; GINKGOLIDE J; LACTATE DEHYDROGENASE; POTASSIUM CYANIDE;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN HYPOXIA; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ASSAY; ENZYME RELEASE; INCUBATION TIME; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; GINKGOLIDES; HYPOXIA, BRAIN; INDICATORS AND REAGENTS; L-LACTATE DEHYDROGENASE; MICE; MICE, INBRED ICR; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; POISONS; POTASSIUM CYANIDE; TETRAZOLIUM SALTS; TREATMENT OUTCOME;

EID: 34249031927     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-006-0823-x     Document Type: Article

References (35)

1. Ahlemeyer B, Krieglstein J (2003a) Neuroprotective effects of ginkgo biloba extract. Cell Mol Life Sci 60:1779-1792
2. Ahlemeyer B, Krieglstein J (2003b) Pharmacological studies supporting the therapeutic use of ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry 36(Suppl 1):S8-S14
3. Ardelt BK, Borowitz JL, Isom GE (1989) Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication. Toxicology 56:147-154
4. Arechabala B, Coiffard C, Rivalland P, Coiffard LJ, de Roeck Holtzhauer Y (1999) Comparison of cytotoxicity of various surfactants tested on normal human fibroblast cultures using the neutral red test, MTT assay and LDH release. J Appl Toxicol 19:163-165
5. Barth SA, Inselmann G, Engemann R, Heidemann HT (1991) Influences of ginkgo biloba on cyclosporin A induced lipid peroxidation in human liver microsomes in comparison to vitamin E, glutathione and N-acetylcysteine. Biochem Pharmacol 41:1521-1526
6. Bazan NG (1998) The neuromessenger platelet-activating factor in plasticity and neurodegeneration. Prog Brain Res 118:281-291
7. Berman SB, Hastings TG (1999) Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease. J Neurochem 73:1127-1137
8. Braquest P, Hoford D (1991) Ethnopharmacology and the development of natural PAF antagonists as therapeutic agents. J Ethnopharmacol 32:135-139
9. Calcerrada MC, Catalan RE, Martinez AM (1999) Glutamate release is involved in PAF-increased cyclic GMP levels in hippocampus. Biochem Mol Biol Int 47:529-535
10. Chen HS, Wu XM, Zhu L, Jin SY (2001) Protective effects of ginkgolid on hypoxic injury of cultured mouse cortical neurons. Acta Acad Med Nantes 21:226-228
11. Christen Y, Maixent JM (2002) What is ginkgo biloba extract EGb 761? An overview-from molecular biology to clinical medicine. Cell Mol Biol (Noisy-le-grand) 48(6):601-611
12. Dumont E, Petit E, Tarrade T, Nouvelot A (1992) UV-C irradiation-induced peroxidative degradation of microsomal fatty acids and proteins: protection by an extract of ginkgo biloba (EGb 761). Free Radic Biol Med 13:197-203
13. Goldberg MP, Weiss JH, Pharma P, Choi DW (1987) N-Methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture. J Pharmacol Exp Ther 243:784-791
14. Grunewald T, Beal MF (1999) Bioenergetics in Huntington's disease. Ann N Y Acad Sci 893:203-213
15. Haramaki N, Aggarwal S, Kawabata T, Droy-Lefaix MT, Packer L (1994) Effects of natural antioxidant ginkgo biloba extract (EGB 761) on myocardial ischemia-reperfusion injury. Free Radic Biol Med 16:789-794
16. Ho KP, Li L, Zhao L, Qian ZM (2003) Genistein protects primary cortical neurons from iron-induced lipid peroxidation. Mol Cell Biochem 247:219-222
17. Ji QH, Gu JL, Gu YJ, Zhu L (2004) Effect of ginkgol ides, acanthopannx senticosus saponins, ginsenosides on the injury of PC12 cells induced by cobalt chloride. Acta Acad Med Nantes 24:33-36
18. Johnson JD, Conroy WG, Burris KD, Isom GE (1987) Peroxidation of brain lipids following cyanide intoxication in mice. Toxicology 46:21-28
19. Kleijnen J, Knipschild P (1992) Ginkgo biloba. Lancet 340:1136-1139
20. Lichtblau D, Berger JM, Nakanishi K (2002) Efficient extraction of ginkgolides and bilobalide from ginkgo biloba leaves. J Nat Prod 65(10):1501-1504
21. Maclennan KM, Darlington CL, Smith PF (2002) The CNS effects of ginkgo biloba extracts and ginkgolide B. Prog Neurobiol 67:235-257
22. Marcocci L, Packer L, Droy-Lefaix MT, Sekaki A, Gardes-Albert M (1994) Antioxidant action of ginkgo biloba extract EGb 761. Methods Enzymol 234:462-475
23. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J lmmunol Methods 65:55-63
24. Oken BS, Storzbach DM, Kaye JA (1998) The efficacy of ginkgo biloba extract on cognitive function in Alzheimer disease. Arch Neurol 55:1409-1415
25. Onen A, Deveci E, Inaloz SS, Isik B, Kilinc M (1999) Histopathological assessment of the prophylactic effect of ginkgo-biloba extract on intestinal ischemia-reperfusion injury. Acta Gastroenterol Belg 62:386-389
26. 2+-loaded brain neurons. Brain Res 635:125-129
27. Patel MN, Yim GK, Isom GE (1992) Blockade of N-methyl-D-aspartate receptors prevents cyanide-induced neuronal injury in primary hippocampal cultures. Toxicol Appl Pharmacol 115:124-129
28. Rong Y, Geng Z, Lau BH (1996) Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells. Free Radic Biol Med 20:121-127
29. Rothman SM, Olney JW (1987) Excitotoxicity and the NMDA receptor. Trends Neurosci 10:299-302
30. 2+] in hypoxia and ischemia in rat brain in vivo. J Gen Physiol 95:837-866
31. Way JL (1985) Cyanide intoxication and its mechanism of antagonism. Annu Rev Pharmacol Toxicol 24:451-481
32. Zeevalk GD, Nicklas WJ (1990) Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina. J Pharmacol Exp Ther 253:1285-1292
33. Zeevalk GD, Nicktas WJ (1991) Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition. J Pharmacol Exp Ther 257:870-878
34. Zhu L, Wu J, Liao H, Gao J, Zhao X, Zhang Z (1997) Antagonistic effects of extract from leaves of ginkgo biloba on glutamate neurotoxicity. Acta Pharmacol Sin 18:344-347
35. Zhu L, Zhang Y, Chen H, Jin S (2004) Signal transduction pathway of the protective effects of ginkgolides on chemical hypoxia injury to cortical neurons. Acta Biochim Biophys Sin 36:163-166