Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum

Phytochemistry

Volumn 68, Issue 11, 2007, Pages 1587-1594

  Karioti, Anastasia ^a   Skopeliti, Margarita ^a   Tsitsilonis, Ourania ^a   Heilmann, Jörg ^b   Skaltsa, Helen ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Cytotoxicity; Labdane diterpenes; Lamiaceae; Lymphocyte activation; Marrubium cylleneum; Marrubium velutinum; Nor diterpenes

Indexed keywords

ANTINEOPLASTIC AGENT; DITERPENE; IMMUNOLOGIC FACTOR;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; HUMAN; ISOLATION AND PURIFICATION; LYMPHOCYTE; MARRUBIUM; NUCLEAR MAGNETIC RESONANCE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; DITERPENES; HUMANS; IMMUNOLOGIC FACTORS; LYMPHOCYTES; MARRUBIUM; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;

LAMIACEAE; MAGNOLIOPHYTA; MARRUBIUM;

EID: 34249031616     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2007.03.027     Document Type: Article

References (15)

1. Dimas K., Demetzos C., Vaos B., Marselos M., and Kokkinopoulos D. Cytotoxic and antiproliferative effects of heptaacetyltiliroside on human leukemic cell lines. Leuk. Res. 23 (1999) 1021-1033
2. Dimas K., Demetzos C., Angelopoulou D., Kolokouris A., and Mavromoustakos T. Biological activity of myricetin and its derivatives against human leukemic cell lines in vitro. Pharmacol. Res. 42 (2000) 475-478
3. Ellery J.M., and Nicholls P.J. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev. 13 (2002) 27-40
4. Grace M.H., Jin Y., Wilson G.R., and Coates R.M. Structure, biogenetic relationships, and cytotoxicity of pimarane-derived diterpenes from Petalostigma pubescens. Phytochemistry 67 (2006) 1708-1715
5. Henry G.E., Adams L.S., Rosales J.C., Jacobs H., Heber D., and Seeram N.P. Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro. Cancer Lett. 244 (2006) 190-194
6. Iliopoulou D., Mihopoulos N., Vagias C., Papazafiri P., and Roussis V. Novel cytotoxic brominated diterpenes from the red alga Laurencia obtusa. J. Org. Chem. 68 (2003) 7667-7674
7. Karioti A., Skaltsa H., Heilmann J., and Sticher O. Acylated flavonoid and phenylethanoid glycosides from Marrubium velutinum. Phytochemistry 64 (2003) 655-660
8. Karioti A., Heilmann J., and Skaltsa H. Labdane diterpenes from Marrubium velutinum and Marrubium cylleneum. Phytochemistry 66 (2005) 1060-1066
9. Karioti A., Heilmann J., and Skaltsa H. Secondary metabolites from Marrubium velutinum, growing wild in Greece. Zeitschr. Naturforsch. 60b (2005) 1-5
10. Mabberley D.J. The Plant Book. second ed. (1997), Cambridge University Press, Cambridge
11. Papazafiri P., Avlonitis N., Angelou P., Calogeropoulou T., Koufaki M., Scoulica E., and Fragiadaki I. Structure-activity relationships of antineoplastic ring-substituted ether phospholipid derivatives. Cancer Chemother. Pharmacol. 56 (2005) 261-270
12. Rasikari H.L., Leach D.N., Waterman P.G., Spooner-Hart R.N., Basta A.H., Banbury L.K., Winter K.M., and Forster P.I. Cytotoxic clerodane diterpenes from Glossocarya calcicola. Phytochemistry 66 (2005) 2844-2850
13. Rigano D., Grassia A., Bruno M., Rosselli M., Piozzi F., Formisano C., Apostolides-Arnold N., and Senatore F. Labdane diterpenoids from Marrubium globosum ssp. libanoticum. J. Nat. Prod. 69 (2006) 836-838
14. Skopeliti M., Voutsas I.F., Klimentzou P., Tsiatas M.L., Beck A., Bamias A., Moraki M., Livaniou E., Neagu M., Voelter W., and Tsitsilonis O.E. The immunologically active site of prothymosin α is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients. Cancer Immunol. Immunother. 55 (2006) 1247-1257
15. Tsavaris N.B., Katsoulas H.L., Kosmas C., Papalambros E., Gouveris P., Papantoniou N., Rokana S., Kosmas N., Skopeliti M., and Tsitsilonis O.E. The effect of edrecolomab (Mo17-1A) or fluorouracil-based chemotherapy on specific immune parameters in patients with colorectal cancer. A comparative study. Oncology 67 (2004) 403-410