Structural role of the secondary active domain of HIV-2 NCp8 in multi-functionality

Biochemical and Biophysical Research Communications

Volumn 358, Issue 3, 2007, Pages 673-678

  Matsui, Takashi ^a   Kodera, Yoshio ^a   Miyauchi, Emi ^a   Tanaka, Hidekazu ^a   Endoh, Hiroshi ^a   Komatsu, Hiroyoshi ^a   Tanaka, Takeshi ^b   Kohno, Toshiyuki ^b   Maeda, Tadakazu ^a  

^a KITASATO UNIVERSITY   (Japan)

^b MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

Author keywords

2D NMR; HIV; Nucleocapsid protein; RNA binding protein; Zinc finger

Indexed keywords

NUCLEOCAPSID PROTEIN; PROTEIN NCP8; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA; ZINC FINGER PROTEIN;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 2; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RNA BINDING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; CAPSID PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RNA; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC FINGERS;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 34249031153     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.04.141     Document Type: Article

References (23)

1. South T.L., Blake P.R., Hare D.R., and Summers M.F. C-terminal retroviral-type zinc finger domain from the HIV-1 nucleocapsid protein is structurally similar to the N-terminal zinc finger domain. Biochemistry 30 (1991) 6342-6349
2. De Rocquigny H., Gabus C., Vincent A., Fournie-Zaluski M.C., Roques B., and Darlix J.L. Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers. Proc. Natl. Acad. Sci. USA 89 (1992) 6472-6476
3. Lapadat-Tapolsky M., De Rocquigny H., Van Gent D., Roques B., Plasterk R., and Darlix J.L. Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle. Nucleic Acids Res. 21 (1993) 831-839
4. Dannull J., Surovoy A., Jung G., and Moelling K. Specific binding of HIV-1 nucleocapsid protein to PSI RNA in vitro requires N-terminal zinc finger and flanking basic amino acid residues. EMBO J. 13 (1994) 1525-1533
5. De Guzman R.N., Wu Z.R., Stalling C.C., Pappalardo L., Borer P.N., and Summers M.F. Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element. Science 279 (1998) 384-388
6. Amarasinghe G.K., De Guzman R.N., Turner R.B., Chancellor K.J., Wu Z.R., and Summers M.F. NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. implications for genome recognition. J. Mol. Biol. 301 (2000) 491-511
7. Levin J.G., Guo J., Rouzina I., and Musier-Forsyth K. Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: Critical role in reverse transcription and molecular mechanism. Prog. Nucleic Acid Res. Mol. Biol. 80 (2005) 217-286
8. Komatsu H., Tsukahara T., and Tozawa H. Viral RNA binding properties of human immunodeficiency virus type-2 (HIV-2) nucleocapsid protein-derived synthetic peptides. Biochem. Mol. Biol. Int. 38 (1996) 1143-1154
9. Damgaard C.K., Dyhr-Mikkelsen H., and Kjems J. Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions. Nucleic Acids Res. 26 (1998) 3667-3676
10. Wüthrich K. NMR of Proteins and Nucleic Acids (1986), Eiley, New York
11. Jeener J., Meier B.H., Bachmann P., and Ernst R.R. Investigation of exchange processes by two-dimensional NMR spectroscopy. J. Chem. Phys. 71 (1979) 4546-4553
12. Macura S., Huang Y., Suter D., and Ernst R.R. Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins. J. Magn. Reson. 43 (1981) 259-281
13. Pardi A., Billeter M., and Wüthrich K. Calibration of the angular dependence of the amide proton-C alpha proton coupling constants, 3JHN alpha, in a globular protein. use of 3JHN alpha for identification of helical secondary structure. J. Mol. Biol. 180 (1984) 741-751
14. Schwieters C.D., Kuszewski J.J., Tjandra N., and Clore G.M. The xplor-NIH NMR molecular structure determination package. J. Magn. Reson. 160 (2003) 65-73
15. Laskowski R.A., Rullmannn J.A., MacArthur M.W., Kaptein R., and Thornton J.M. AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J. Biomol. NMR 8 (1996) 477-486
16. Koradi R., Billeter M., and Wüthrich K. MOLMOL: a program for display and analysis of macromolecular structures. J. Mol. Graph. 14 (1996) 51-5-29-32
17. Matsui T., Kodera Y., Endoh H., Miyauchi E., Komatsu H., Sato K., Tanaka T., Kohno T., and Maeda T. RNA recognition mechanism of the minimal active domain of the human immunodeficiency virus type-2 nucleocapsid protein. J. Biochem. (Tokyo) 141 (2007) 269-277
18. Summers M.F., South T.L., Kim B., and Hare D.R. High-resolution structure of an HIV zinc fingerlike domain via a new NMR-based distance geometry approach. Biochemistry 29 (1990) 329-340
19. Kodera Y., Sato K., Tsukahara T., Komatsu H., Maeda T., and Kohno T. High-resolution solution NMR structure of the minimal active domain of the human immunodeficiency virus type-2 nucleocapsid protein. Biochemistry 37 (1998) 17704-17713
20. Morellet N., de Rocquigny H., Mély Y., Jullian N., Déméné H., Ottmann M., Gerard D., Darlix J.L., Fournie-Zaluski M.C., and Roques B.P. Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR. J. Mol. Biol. 235 (1994) 287-301
21. Morellet N., Déméné H., Teilleux V., Huynh-Dinh T., de Rocquigny H., Fournie-Zaluski M.C., and Roques B.P. Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC). J. Mol. Biol. 283 (1998) 419-434
22. Hasegawa A., Tsujimoto H., Maki N., Ishikawa K., Miura T., Fukasawa M., Miki K., and Hayami M. Genomic divergence of HIV-2 from ghana. AIDS Res. Hum. Retroviruses 5 (1989) 593-604
23. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31 (2003) 3406-3415