Iron deposition and fat accumulation in dimethylnitrosamine-induced liver fibrosis in rat

World Journal of Gastroenterology

Volumn 13, Issue 14, 2007, Pages 2061-2065

  He, Jin Yang ^a   Ge, Wen Hua ^a   Chen, Yuan ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Dimethylnitrosamine; Fat; Iron; Liver fibrosis

Indexed keywords

ALANINE AMINOTRANSFERASE; COLLAGEN; DIMETHYLNITROSAMINE; EOSIN; HEMATOXYLIN; HYDROXYPROLINE; IRON; SODIUM CHLORIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; HISTOPATHOLOGY; IRON STORAGE; LIPID STORAGE; LIVER CELL; LIVER FIBROSIS; MALE; NONHUMAN; PROTEIN DETERMINATION; RAT; STAINING; TISSUE LEVEL;

EID: 34249017903     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i14.2061     Document Type: Article

References (33)

1. Purohit V, Russo D, Salin M. Role of iron in alcoholic liver disease: introduction and summary of the symposium. Alcohol 2003; 30: 93-97
2. Thorburn D, Curry G, Spooner R, Spence E, Oien K, Halls D, Fox R, McCruden EA, MacSween RN, Mills PR. The role of iron and haemochromatosis gene mutations in the progression of liver disease in chronic hepatitis C. Gut 2002; 50: 248-252
3. Tung BY, Emond MJ, Bronner MP, Raaka SD, Cotler SJ, Kowdley KV. Hepatitis C, iron status, and disease severity: relationship with HFE mutations. Gastroenterology 2003; 124: 318-326
4. Erhardt A, Maschner-Olberg A, Mellenthin C, Kappert G, Adams O, Donner A, Willers R, Niederau C, Haussinger D. HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. J Hepatol 2003; 38: 335-342
5. Powell EE, Jonsson JR, Clouston AD. Steatosis: Co-factor in Other Liver Diseases. Hepatology 2005; 42: 5-13
6. Lopez A, Carmona CA, Moussatche H. On the mechanism of protective action of cold acclimatization against carbon tetrachloride- and ethionine-induced fatty liver. Mem Inst Oswaldo Cruz 1993; 88: 313-316
7. Batey RG, Johnston R. Effects of alcohol, carbon tetrachloride, and choline deficiency on iron metabolism in the rat. Alcohol Clin Exp Res 1993; 17: 931-934
8. Khan MF, Wu X, Tipnis UR, Ansari GA, Boor PJ. Protein adducts of malondialdehyde and 4-hydroxynonenal in livers of iron loaded rats: quantitation and localization. Toxicology 2002; 173: 193-201
9. Svegliati-Baroni G, Saccomanno S, van Goor H, Jansen P, Benedetti A, Moshage H. Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver 2001; 21: 1-12
10. Wang GS, Eriksson LC, Xia L, Olsson J, Stal P. Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation. J Hepatol 1999; 30: 689-698
11. Day CP, James OF. Hepatic steatosis: innocent bystander or guilty party? Hepatology 1998; 27: 1463-1466
12. Leandro G, Mangia A, Hui J, Fabris P, Rubbia-Brandt L, Colloredo G, Adinolfi LE, Asselah T, Jonsson JR, Smedile A, Terrault N, Pazienza V, Giordani MT, Giostra E, Sonzogni A, Ruggiero G, Marcellin P, Powell EE, George J, Negro F. Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data. Gastroenterology 2006; 130: 1636-1642
13. Yen MH, Weng TC, Liu SY, Chai CY, Lin CC. The hepatoprotective effect of Bupleurum kaoi, an endemic plant to Taiwan, against dimethylnitrosamine-induced hepatic fibrosis in rats. Biol Pharm Bull 2005; 28: 442-448
14. Sakaida I, Hironaka K, Terai S, Okita K. Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells. Life Sci 2003; 72: 943-959
15. Hu QW, Liu GT. Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action. Life Sci 2006; 79: 606-612
16. George J. Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis. Clin Biochem 2006; 39: 984-991
17. Jenkins SA, Grandison A, Baxter JN, Day DW, Taylor I, Shields R. A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat. J Hepatol 1985; 1: 489-499
18. Franzen LE, Ekstedt M, Kechagias S, Bodin L. Semiquantitative evaluation overestimates the degree of steatosis in liver biopsies: a comparison to stereological point counting. Mod Pathol 2005; 18: 912-916
19. Jezequel AM, Mancini R, Rinaldesi ML, Ballardini G, Fallani M, Bianchi F, Orlandi F. Dimethylnitrosamine-induced cirrhosis. Evidence for an immunological mechanism. J Hepatol 1989; 8: 42-52
20. Jezequel AM, Mancini R, Rinaldesi ML, Macarri G, Venturini C, Orlandi F. A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat. J Hepato 1987; 5: 174-181
21. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103-1109
22. Reeves HL, Burt AD, Wood S, Day CP. Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis. J Hepatol 1996; 25: 677-683
23. Lieber CS. Alcohol and the liver: 1994 update. Gastroenterology 1994; 106: 1085-1105
24. Diehl AM, Goodman Z, Ishak KG. Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury. Gastroenterology 1988; 95: 1056-1062
25. Mueller S, Afdhal NH, Schuppan D. Iron, HCV, and liver cancer: hard metal setting the pace? Gastroenterology 2006; 130: 2229-2234
26. Ioannou GN, Kowdley KV. Iron, HFE mutations, and hepatocellular carcinoma: is hepatic iron a carcinogen? Clin Gastroenterol Hepatol 2003; 1: 246-248
27. Chrobot A, Chrobot AM, Szaflarska-Szczepanik A. Assessment of iron metabolism in children with chronic hepatitis B -- prognostic factor in interferon alpha therapy. Med Sci Monit 2002; 8: CR269-CR273
28. Sebastiani G, Vario A, Ferrari A, Pistis R, Noventa F, Alberti A. Hepatic iron, liver steatosis and viral genotypes in patients with chronic hepatitis C. J Viral Hepat 2006; 13: 199-205
29. Kohgo Y, Ohtake T, Ikuta K, Suzuki Y, Hosoki Y, Saito H, Kato J. Iron accumulation in alcoholic liver diseases. Alcohol Clin Exp Res 2005; 29: 189S-193S
30. Fierbinteanu-Braticevici C, Bengus A, Neamtu M, Usvat R. The risk factors of fibrosis in nonalcoholic steatohepatitis. Rom J Intern Med 2002; 40: 81-88
31. Bugianesi E, Manzini P, D'Antico S, Vanni E, Longo F, Leone N, Massarenti P, Piga A, Marchesini G, Rizzetto M. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology 2004; 39: 179-187
32. Arezzini B, Lunghi B, Lungarella G, Gardi C. Iron overload enhances the development of experimental liver cirrhosis in mice. Int J Biochem Cell Biol 2003; 35: 486-495
33. Corradini E, Ferrara F, Pietrangelo A. Iron and the liver. Pediatr Endocrinol Rev 2004; 2 Suppl 2: 245-248