A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity

Drug Metabolism and Disposition

Volumn 35, Issue 6, 2007, Pages 973-980

  Gonzalez Covarrubias, Vanessa ^a   Ghosh, Debashis ^b,c   Lakhman, Sukhwinder S ^a   Pendyala, Lakshmi ^c   Blanco, Javier G ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL REDUCTASE; CARBONYL REDUCTASE 1; COMPLEMENTARY DNA; DAUNORUBICIN; DAUNORUBICINOL; ISOLEUCINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RUTOSIDE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALORIMETRY; CATALYSIS; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG INHIBITION; ENZYME ACTIVITY; HUMAN; IC 50; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; X RAY CRYSTALLOGRAPHY;

ALCOHOL OXIDOREDUCTASES; CATALYSIS; CLONING, MOLECULAR; DAUNORUBICIN; DNA, COMPLEMENTARY; GENOTYPE; HUMANS; KINETICS; MODELS, MOLECULAR; NADP; POLYMORPHISM, SINGLE NUCLEOTIDE; RUTIN; SEQUENCE ANALYSIS, DNA;

EID: 34249009348     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.014779     Document Type: Article

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