Confirmation of tick bite by detection of antibody to Ixodes calreticulin salivary protein

Clinical and Vaccine Immunology

Volumn 13, Issue 11, 2006, Pages 1217-1222

  Alarcon Chaidez, Francisco ^a   Ryan, Raymond ^a   Wikel, Stephen ^a   Dardick, Kenneth ^a   Lawler, Caroline ^a   Foppa, Ivo M ^b   Tomas, Patricio ^a,e   Cushman, Alexis ^a,f   Hsieh, Ann ^a,g   Spielman, Andrew ^c   Bouchard, Keith R ^a   Dias, Filiciano ^a   Aslanzadeh, Jaber ^a   Krause, Peter J ^a,d  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d Division of Pediatric Infectious Diseases   (United States)

^e Invitrogen Corporation   (United States)

^f 3859 Middlebury College ^*  (United States)

^g MIDDLEBURY COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALRETICULIN; CALRETICULIN ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; ANTIBODY; RECOMBINANT PROTEIN; SALIVA PROTEIN;

ANAPLASMOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABESIOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNE RESPONSE; IXODES SCAPULARIS; LYME DISEASE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SALIVARY GLAND; TICK BITE; TICK BORNE DISEASE; ANIMAL; BAGG ALBINO MOUSE; BITES AND STINGS; BLOOD; C3H MOUSE; CYTOLOGY; GENETICS; IMMUNOLOGY; IXODES;

ANIMALS; ANTIBODIES; BITES AND STINGS; CALRETICULIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IXODES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MODELS, ANIMAL; RECOMBINANT PROTEINS; SALIVARY PROTEINS;

EID: 34248664048     PISSN: 15566811     EISSN: None     Source Type: Journal    
DOI: 10.1128/CVI.00201-06     Document Type: Article

References (36)

1. Beaudouin, E., G. Kanny, B. Guerin, L. Guerin, F. Plenat, and D. A. Moneret-Vautrin. 1997. Unusual manifestations of hypersensitivity after tick bite: report of two cases. Ann. Allergy Asthma Immunol. 79:43-46.
2. Bell, J. F., S. J. Stewart, and S. K. Wikel. 1979. Resistance to tick-borne Francisella tularensis by tick-sensitized rabbits: allergic klendusity. Am. J. Trop. Med. Hyg. 28:876-880.
3. Bergman, D. K., M. J. Palmer, M. J. Caimano, J. D. Radolf, and S. K. Wikel. 2000. Isolation and molecular cloning of a secreted immunosuppressant protein from Dermacentor andersoni salivary gland. J. Parasitol. 86:516-525.
4. Bouchard, K. R., and S. K. Wikel. 2005. Care, maintenance, and experimental infestation of ticks in the laboratory setting, p. 705-711. In W.C. Marquart (ed.), Biology of disease vectors, 2nd ed. Elsevier Academic Press, San Diego, Calif.
5. Brossard, M., and S. K. Wikel. 2004. Tick immunobiology. Parasitology 129:S161-S176.
6. Burke, G., S. K. Wikel, A. Spielman, S. R. Telford, K. McKay, P. J. Krause, et al. 2005. Hypersensitivity to ticks and Lyme disease risk. Emerg. Infect. Dis. 11:36-41.
7. Fivaz, B. H. 1989. Immune suppression induced by the brown ear tick Rhipicephalus appendiculatus. J. Parasitol. 75:946-952.
8. Krause, P. J., K. McKay, J. Gadbaw, D. Christianson, L. Closter, T. Lepore, S. A. Telford, V. Sikand, R. Ryan, D. Persing, J. D. Radolf, A. Spielman, et al. 2003. Increasing health burden of human babesiosis in endemic sites. Am. J. Trop. Med. Hyg. 68:431-436.
9. Krinsky, W. L. 1983. Dermatoses associated with the bites of mites and ticks (Arthropoda: Acari). Int. J. Dermatol. 22:75-91.
10. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
11. Magnarelli, L. A., J. M. Meegan, J. F. Anderson, and W. A. Chappell. 1984. Comparison of an indirect fluorescent-antibody test with an enzyme-linked immunosorbent assay for serological studies of Lyme disease. J. Clin. Microbiol. 20:181-184.
12. Marshall, J. 1967. Ticks and human skin. Dermatologica 135:60-65.
13. Mejri, N., B. Rutti, and M. Brossard. 2002. Immunosuppressive effects of Ixodes ricinus tick saliva or salivary gland extracts on innate and acquired immune response of BALB/c mice. Parasitol. Res. 88:192-197.
14. Nazario, S., S. Das, A. M. de Silva, K. Deponte, N. Marcantonio, J. F. Anderson, D. Fish, E. Fikrig, and F. Kantor. 1998. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity. Am. J. Trop. Med. Hyg. 58:780-785.
15. Ribeiro, J. M. C. 1995. Blood-feeding arthropods: live syringes or invertebrate pharmacologists? Infect. Agents Dis. 4:143-152.
16. Ribeiro, J. M. C., and T. N. Mather. 1998. Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase. Exp. Parasitol. 89:213-221.
17. Ribeiro, J. M. C., and I. M. B. Francischetti. 2003. Role of arthropod saliva in blood feeding. Sialome and post-sialome perspectives. Annu. Rev. Entomol. 48:73-88.
18. Ribeiro, J. M. C., F., Alarcon-Chaidez, I. M. B. Francischetti, B. Mans, T. N. Mather, J. G. Valenzuela, and S. K. Wikel. 2006. An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks. Insect Biochem. Mol. Biol. 36:111-129.
19. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
20. Sanders, M. L., G. E. Glass, R. B. Nadelman, G. Wormser, A. L. Scott, S. Raha, B. C. Ritchie, D. C. Jaworski, and B. S. Schwartz. 1999. Antibody levels to recombinant tick calreticulin increase after exposure to Ixodes scapularis (Say) and are correlated with tick engorgement indices. Am. J. Epidemiol. 149:777-784.
21. Sanders, M. L., D. C. Jaworski, J. L. Sanchez, R. F. DeFraites, G. E. Glass, A. L. Scott, S. Raha, B. C. Ritchie, G. R. Needham, and B. S. Schwartz. 1998. Antibody to a cDNA-derived calreticulin protein from Amblyomma americanum as a biomarker of tick exposure in humans. Am. J. Trop. Med. Hyg. 59:279-285.
22. Schoeler, G. B., and S. K. Wikel. 2001. Modulation of host immunity by haematophagous arthropods. Ann. Trop. Med. Parasitol. 95:755-771.
23. Schwartz, B. S., D. P. Ford, J. E. Childs, N. Rothman, and R. J. Thomas. 1991. Anti-tick saliva antibody: a biologic marker of tick exposure that is a risk factor for Lyme disease seropositivity. Am. J. Epidemiol. 134:86-95.
24. Schwartz, B. S., M. D. Goldstein, and J. E. Childs. 1993. Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers. Am. J. Public Health 83:1746-1748.
25. Schwartz, B. S., R. B. Nadelman, D. Fish, J. E. Childs, G. Forseter, and G. Wormser. 1993. Entomologic and demographic correlates of anti-tick saliva antibody in a prospective study of tick bite subjects in Westchester County, New York. Am. J. Trop. Med. Hyg. 48:50-57.
26. Schwartz, B. S., J. M. C. Ribeiro, and M. D. Goldstein. 1990. Anti-tick antibodies: an epidemiologic tool in Lyme disease research. Am. J. Epidemiol. 132:58-66.
27. Smith, P. K., R. I. Krohn, G. T. Hermanson, A. K. Mallia, F. H. Gartner, M. D. Provenzano, E. K. Fujimoto, N. M. Goeke, B. J Olson, and D. C. Klenk. 1985. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:76-85.
28. Theilmann, D. A., and S. Stewart. 1992. Molecular analysis of the transactivating IE-2 gene of Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus. Virology 187:84-96.
29. Valenzuela, J. G. 2004. Exploring tick saliva: from biochemistry to 'sialomes' and functional genomics. Parasitology 129:S83-S94.
30. Wikel, S. K. 1982. Immune responses to arthropods and their products. Annu. Rev. Entomol. 27:21-48.
31. Wikel, S. K. 1985. Effects of tick infestation on the plaque-forming cell response to a thymic dependent antigen. Ann. Trop. Med. Parasitol. 79:195-198.
32. Wikel, S. K. 1996. Host immunity to ticks. Annu. Rev. Entomol. 41:1-22.
33. Wikel, S. K., and D. K. Bergman. 1997. Tick-host immunology: significant advances and challenging opportunities. Parasitol. Today 13:383-389.
34. Wikel, S. K., R. N. Ramachandra, D. K. Bergman, T. R. Burkot, and J. Piesman. 1997. Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks. Infect. Immun. 65:335-338.
35. Williams, C. L., B. Strobino, A. Lee, A. S. Curran, J. L. Benach, S. Inamdar, and R. Cristofaro. 1990. Lyme disease in childhood: clinical and epidemiologic features of ninety cases. Pediatr. Infect. Dis. J. 9:10-14.
36. Xu, G., Q. Q. Fang, Y. Sun, J. E. Keirans, and L. A. Durden. 2005. Hard tick calreticulin (CRT) gene coding regions have only one intron with conserved positions and variable sizes. J. Parasitol. 91:1326-1331.