Novel acyclic enediynes inhibit Cyclin A and Cdc25C expression and induce apoptosis phenomenon to show potent antitumor proliferation

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 13, 2007, Pages 4528-4536

  Lo, Yu Hsiang ^a   Lin, I Ling ^a   Lin, Chi Fong ^b   Hsu, Cheng Chung ^a   Yang, Sheng Huei ^a   Lin, Shinne Ren ^a   Wu, Ming Jung ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

Author keywords

Apoptosis; Cdc25C; Cyclin A; Enediyne; G2 M phase arrest

Indexed keywords

6 (2 (2 ANILINYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 ANISYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 FLUOROPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 NAPHTHALENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 NITROPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 PYRAZINYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 PYRIDINYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 THIEANISYLYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 THIENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 TRIFLUOROMETHYLPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2 XYLENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2,3,4,5,6 PENTAFLUOROPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (2,4 DIFLUOROPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (3 ANISYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (3 HYDROXYPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (3 PYRIDINYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (3 TRIFLUOROMETHYLPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (4 ANILINYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (4 ANISYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (4 CYANOPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (4 HYDROXYPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; 6 (2 (4 TRIFLUOROMETHYLPHENYLETHYNYL))PHENYL 5 HEXYN 1 OL; ACYCLIC ENEDIYNE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN A; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN A; HUMANS; INDICATORS AND REAGENTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34248651233     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.04.024     Document Type: Article

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