Urinary arsenic methylation and porphyrin profile of C57Bl/6J mice chronically exposed to sodium arsenate

Science of the Total Environment

Volumn 379, Issue 2-3, 2007, Pages 235-243

  Krishnamohan, Manonmanii ^a   Wu, Hui Jie ^b   Huang, Shu Huei ^a   Maddelena, Robyn ^a   Lam, Paul K S ^b   Moore, Michael R ^a   Ng, Jack C ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Arsenic; Biomarker; Chronic exposure; Methylation; Mice; Porphyrin

Indexed keywords

BIOMARKERS; BIOSYNTHESIS; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHYLATION; PORPHYRINS; RATS; WATER ANALYSIS;

HAEM BIOSYNTHESIS; SODIUM ARSENATE; URINARY COPROPORPHYRIN; URINE;

ARSENIC;

ARSENATE SODIUM; BIOLOGICAL MARKER; COPROPORPHYRIN; DRINKING WATER; PORPHYRIN;

ARSENIC; BIOMARKER; CANCER; DOSE-RESPONSE RELATIONSHIP; METHYLATION; POLLUTION EFFECT; POLLUTION EXPOSURE; RODENT; URINE;

ANIMAL EXPERIMENT; ARTICLE; ATOMIC EMISSION SPECTROMETRY; C57BL 6 MOUSE; CANCER; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LONG TERM EXPOSURE; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING; URINALYSIS; URINE LEVEL; WATER CONTAMINATION;

ANIMALS; ARSENATES; ARSENIC; BIOLOGICAL MARKERS; CARCINOGENS; FEMALE; METHYLATION; MICE; MICE, INBRED C57BL; NEOPLASMS; PORPHYRINS;

MUS;

EID: 34248643129     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2006.08.052     Document Type: Article

References (79)

1. Aposhian H.V. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu Rev Pharmacol Toxicol 37 (1997) 397-419
2. Aposhian H.V., Gurzau E.S., Le X.C., Gurzau A., Healy S.M., Lu X., et al. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. Chem Res Toxicol 13 (2000) 693-697
3. Aposhian H.V., Zheng B.S., Aposhian M.M., Le X.C., Cebrian M.E., Cullen W., et al. Dmps-arsenic challenge test ii. Modulation of arsenic species, including monomethylarsonous acid (MMAIII), excreted in human urine. Toxicol Appl Pharmacol 165 (2000) 74-83
4. ATSDR. Toxicological profile of arsenic. US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. 2000.
5. Buchet J.P., Roels H., Lauwerys R., Bruaux P., Thoreau-Claeys F., Lafontaine A., et al. Repeated surveillance of exposure to cadmium, manganese, and arsenic in school-age children living in rural, urban, and nonferrous smelter areas in Belgium. Environ Res 22 (1980) 95-108
6. Buchet J.P., Lauwerys R., and Roels H. Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man. Int Arch Occup Environ Health 48 (1981) 71-79
7. Concha G., Nermell B., and Vahter M. Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. Environ Health Perspect 106 (1998) 355-359
8. Csanaky L., and Gregus Z. Species variations in the biliary and urinary excretion of arsenate, arsenite and their metabolites. Comp Biochem Physiol C- Toxicol Pharmacol 131 (2002) 355-365
9. Cullen W.R., and Reimer K.J. Arsenic speciation in the environment. Chem Rev 89 (1989) 713-764
10. Cullen W.R., McBride B.C., and Reglinski J. The reduction of trimethylarsine oxide to trimethylarsine by thiols: A mechanistic model for the biological reduction of arsenicals. J Inorg Biochem 21 (1984) 45-60
11. Del Razo M.L., Garcia-Vargas G.G., Vargas H., Albores A., Gonsebatt M.E., Montero R., et al. Altered profile of urinary arsenic metabolites in adults with chronic arsenicism - a pilot study. Arch Toxicol 71 (1997) 211-217
12. Del Razo L.M., Stybo M., Cullen W.R., and Thomas D.J. Determination of trivalent methylated arsenicals in biological matrices. Toxicol Appl Pharmacol 174 (2001) 282-293
13. Foa V., and Colombi A. The speciation of the chemical forms of arsenic in the biological monitoring of exposure to ingested arsenic. Sci Total Environ 34 (1984) 241-259
14. Garcia-Vargas G.G., and A.H.Z. Urinary porphyrin and haem biosynthetic enzyme activities measured by HPLC in arsenic toxicity. Biomed Chromatogr 10 (1996) 278-284
15. Garcia-Vargas G.G., Del Razo L.M., Cebrian M.E., Albores A., Ostro-Wegman P., Montero R., et al. Altered urinary porphyrin excretion in a human population chronically exposed to arsenic in Mexico. Hum Exp Toxicol 13 (1994) 839-847
16. Garcia-Vargas G.G., Cebria M.E., Albore A., Lim C.K., and De Matteis F. Time-dependent porphyric response in mice subchronically exposed to arsenic. Hum Exp Toxicol 14 (1995) 475-483
17. Gebel T. Arsenic methylation is a process of detoxification through accelerated excretion. Int J Hyg Environ Health 205 (2002) 505-508
18. Healy S.M., Zakharyan R.A., and Aposhian H.V. Enzymatic methylation of arsenic compounds: Iv. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig. Mutat Res 386 (1997) 229-239
19. Hopenhayn Rich C., Biggs M.L., Kalman D.A., Moore L.E., and Smith A.H. Arsenic methylation patterns before and after changing from high to lower. Environ Health Perspect 104 (1996) 1200-1207
20. Hopenhayn-Rich C., Biggs M.L., Fuchs A., Bergoglio R., Tello E.E., Nicolli H., et al. Bladder cancer mortality associated with arsenic in drinking water in Argentina. Epidemiology 7 (1996) 117-124
21. Hopenhayn-Rich C., Biggs M.L.C., Smith A.H., Kalman D.A., and Moore L.E. Methylation study of a population environmentally exposed to arsenic in drinking water. Environ Health Perspect 104 (1996) 620-628
22. Hsu K.H., Froines J.R., and Chen C.J. Studies of arsenic ingestion from drinking water in northeastern Taiwan: chemical speciation and urinary metabolites. In: Abernathy C.O., Calderon R.L., and Chappell W.R. (Eds). Arsenic: Exposure and health effects (1997), Chapman & Hall, London 190-209
23. IARC. Arsenic and Arsenic Compounds (group 1). IARC monographs on the evaluation of the carcinogenic risks to humans (1987) Supplement 7
24. IARC. Some drinking-water disinfectants and contaminants, including arsenic. Monograph vol. 84 (2004), IARC, Lyon, France 512 pp.
25. IPCS. Environmental health criteria 224. Arsenic and arsenic compounds (2001), WHO, Geneva 1-521 pp.
26. Karagas M.R., Tosteson T.D., Blum J., Klaue B., Weiss J.E., and Stannard V. Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations. Am J Epidemiol 152 (2000) 84-90
27. Koch I., Feldmann J., Wang L., Andrews P., Reimer K.J., and Cullen W.R. Arsenic in the meager creek hot springs environment, British Columbia, Canada. Sci Total Environ 236 (1999) 101-117
28. Le X.C., Lu X., Ma M., Cullen W., Aposhian H.V., and Zheng B.S. Speciation of key arsenic metabolic intermediates in human urine. Anal Chem 72 (2000) 5172-5177
29. Le X.C., Ma M., Cullen W.R., Aposhian H.V., Lu X., and Zheng B. Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. Environ Health Perspect 108 (2000) 1015-1018
30. Li J.H., and Rossman T.G. Mechanism of comutagenesis of sodium arsenite with n-methyl-n-nitrosourea. Biol Trace Elem Res 21 (1989) 373-380
31. Mandal B.K., Ogra Y., and Suzuki K.T. Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in west Bengal, India. Chem Res Toxicol 14 (2001) 371-378
32. Mandal B.K., Ogra Y., and Suzuki K.T. Speciation of arsenic in human nail and hair from arsenic-affected area by HPLC-inductively coupled argon plasma mass spectrometry. Toxicol Appl Pharmacol 189 (2003) 73-83
33. Marafante E., Vahter M., Norin H., Envall J., Sandstrom M., Christakopoulos A., et al. Biotransformation of dimethylarsenic acid in mouse, hamster and man. J Appl Toxicol 7 (1987) 111-117
34. Marks G. Exposure to toxic agents: the heme biosynthetic pathway and hemoproteins as indicator. CRC Crit Rev Toxicol 15 (1985) 151-179
35. Martinez G., Cebrian M., Chamorro G., and Jauge P. Urinary uroporphyrin as an indicator of arsenic exposure in rats. Proc West Pharmacol Soc 26 (1983) 171-174
36. Mass M.J., Tennant A., Roop B.C., Cullen W.R., Styblo M., Thomas D.J., et al. Methylated trivalent arsenic species are genotoxic. Chem Res Toxicol 14 (2001) 355-361
37. Moore M., McColl K., Rimington C., and Goldberg A. Disorders of porphyrin metabolism (1987), Plenum Medical Book Company, New York 1-374
38. Moore M.M., Harrington-Brock K., and Doerr C.L. Relative genotoxic potency of arsenic and its methylated metabolites. Mutat Res 386 (1997) 279-290
39. Morikawa T., Wanibuchi H., Morimura K., Motome O., and Shoji F. Promotion of skin carcinogenesis by dimethylarsenic acid in keratin (k6)/ODC transgenic mice. Jpn J Cancer Res 91 (2000) 579-581
40. Ng J.C., and Qi L. Mutations in C57bl/6j and metallothionin knock-out mice ingested sodium arsenate in drinking water for over two years. In: Chappel W.R., Abernath C.O., and Calderron R.L. (Eds). Arsenic: Exposure and health effects vol. IV (2001), Elsevier Science, Amsterdam 231-242
41. Ng J.C., Seawright A.A., Qi L., Garnet C.M., and Moore M.R. Tumours in mice induced by exposure to sodium arsenate in drinking water. In: Chappell W.R., Abernathy C.O., and Caldron R. (Eds). Arsenic: Exposure and health effects vol. III (1999), Elsevier Science, London 217-223
42. Ng J.C., Seawright A.A., and Moore M.R. The role of metallothionein in arsenic carcinogenesis. Toxicology 164 (2001) 59-60
43. Ng J.C., Qi L., and Moore M.R. HPLC measurement of hardenoporphyrin in the harderian glands of rodents as a biomarker for sub-lethal or chronic arsenic exposure. Toxicol Lett 133 (2002) 93-101
44. Ng J.C., Qi L.X., and Moore M.R. Porphyrin profiles in blood and urine as a biomarker for exposure to various arsenic species. Cell Mol Biol 48 (2002) 111-123
45. Ng J.C., Wang J.P., Zheng B.S., Zhai C., Maddalena R., Liu F., et al. Urinary porphyrins as biomarkers for arsenic exposure among susceptible populations in Guizhou Province, China. Toxicol Appl Pharmacol 206 (2005) 176-184
46. NRC. National research council: Arsenic in drinking water (1999), National Academy Press, Washington 1-310
47. Petrick J.S., Ayala-Fierro F., Cullen W.R., Carter D.E., and Aposhian H.V. Monomethylarsonous acid (MMAIII) is more toxic than arsenite in Chang human hepatocytes. Toxicol Appl Pharmacol 163 (2000) 203-207
48. Petrick J.S., Jagadish B., Mash E.A., and Aposhian H.V. Monomethylarsonous acid (MMAIII) and arsenite: LD50 in hamsters and in vitro inhibition of puyruvate dehydrogenenase. Chem Res Toxicol 14 (2001) 651-656
49. Rahman M., Tondel M., Chowdhury I.A., and Axelson O. Relations between exposure to arsenic, skin lesions and glucosuria. Occup Environ Med 56 (1999) 277-281
50. Shraim A., Cui X., Li S., Ng J.C., Wang H.P., Jin Y.L., et al. Arsenic speciation in the urine and hair of individuals exposed to airborne arsenic through coal-burning in Guizhou, PR China. Toxicol Lett 137 (2003) 35-48
51. Styblo M., Delnomdedieu M., and Thomas D.J. Biological mechanisms and toxicological consequences of the methylation of arsenic. In: Goyer R.A., and Cherian M.G. (Eds). Toxicology of metals - biochemical aspects (1995), Springer-Verlag, Berlin 407-433
52. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., et al. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch Toxicol 74 (2000) 289-299
53. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., et al. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch Toxicol 74 (2000) 289-299
54. Tam G.K., Charbonneau S.M., Bryce F., Pomroy C., and Sandi E. Metabolism of inorganic arsenic (74as) in humans following oral ingestion. Toxicol Appl Pharmacol 50 (1979) 319-322
55. Tseng C.H., Chong C.K., Chen C.J., and Tai T.Y. Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan. Atherosclerosis 120 (1996) 125-133
56. Tseng C.-H., Tseng C.-P., Chiou H.-Y., Hsueh Y.-M., Chong C.-K., and Chen C.-J. Epidemiologic evidence of diabetogenic effect of arsenic. Toxicol Lett 133 (2002) 69-76
57. Tseng C.-H., Chong C.-K., Tseng C.-P., Hsueh Y.-M., Chiou H.-Y., Tseng C.-C., et al. Long-term arsenic exposure and ischemic heart disease in arseniasis-hyperendemic villages in Taiwan. Toxicol Lett 137 (2003) 15-21
58. Vahter M. Species differences in the metabolism of arsenic compounds. Appl Organomet Chem 8 (1994) 175-182
59. Vahter M. Methylation of inorganic arsenic in different mammalian species and population groups. Sci Progr 82 (1999) 69-88
60. Vahter M., and Marafante E. Intracellular distribution and metabolic fate of arsenite and arsenate in mice and rabbits. Chem Biol Interact 47 (1983) 29-44
61. Vahter M., and Marafante E. Reduction and binding of arsenate in marmoset monkeys. Arch Toxicol 57 (1985) 119-124
62. Vahter M., Marafante E., Lindgren A., and Dencker L. Tissue distribution and subcellular binding of arsenic in marmoset monkeys after injection of 74as-arsenite. Arch Toxicol 51 (1982) 65-77
63. Vahter M., Concha G., Nermell B., Nilsson R., Dulout F., and Natarajan A.T. A unique metabolism of inorganic arsenic in native Andean women. Pharmacol Environ Toxicol Pharmacol Section 293 (1995) 455-462
64. Vahter M., Couch R., Nermell B., and Nilsson R. Lack of methylation of inorganic arsenic in the chimpanzee. Toxicol Appl Pharmacol 133 (1995) 262-268
65. Waalkes M.P., Liu J., Ward J.M., and Diwan B.A. Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice. Toxicol Appl Pharmacol 198 (2004) 377-384
66. Wang J.P., Qi L., Zheng B., Liu F., Moore M.R., and Ng J.C. Porphyrins as early biomarkers for arsenic exposure in animals and humans. Cell Mol Biol 48 (2002) 835-843
67. Wanibuchi H., Yamamoto S., Chen H., Yoshida K., Endo G., Hori T., et al. Promoting effects of dimethylarsinic acid on n-butyl-n-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats. Carcinogenesis 17 (1996) 2435-2439
68. Warner M.L., Moore L.E., Smith M.T., Kalman D.A., Fanning E., and Smith A.H. Increased micronuclei in exfoliated bladder cells of individuals who chronically ingest arsenic-contaminated water in Nevada. Cancer Epidemiol Biomarkers Prev 3 (1994) 583-590
69. Wei L., Wanibuchi H., Elsayed I., Yamamoto S., Yoshida, Endo G., et al. Promotion of ncl-black-reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound. Cancer Lett 134 (1998) 29-36
70. Wei M., Wanibuchi H., Yamamoto S., Li W., and Fukushima S. Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats. Carcinogenesis 20 9 (1999) 1873-1876
71. Wei M., Wanibuchi H., Morimura K., Iwai S., and Yoshida. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic. Carcinogenesis 23 (2002) 1387-1397
72. Woods J.S., and Fowler B.A. Effects of chronic arsenic exposure on hematopoietic function in adult mammalian liver. Environ Health Perspect 19 (1977) 209-213
73. Woods J.S., and Fowler B.A. Altered regulation of mammalian hepatic heme biosynthesis and urinary porphyrin excretion during prolonged exposure to sodium arsenate. Toxicol Appl Pharmacol 43 (1978) 361-371
74. Wu M.-M., Kuo T.-L., Hwang Y.-H., and Chen C.-J. Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. Am J Epidemiol 130 (1989) 1123-1132
75. Wu H., Manonmanii K., Lam P.K.S., Huang S.-H., Wang J.P., and Ng J.C. Urinary arsenic speciation and porphyrins in c57b1/6j mice chronically exposed to low doses of sodium arsenate. Toxicol Lett 154 (2004) 149-157
76. Yamanaka K., Hayashi H., Kato K., Hasegaw A., and Okada S. Involvement of preferential formation of apurinic/apyrimidinic sites in dimethylarsenic-induced DNA strand breaks and DNA-protein crosslinks in cultured alveolar epithelial cells. Biochem Biophys Res Commun 207 (1995) 244-249
77. Yamanaka K., Ohtsubo K., Hasegawa A., Hayashi H., Ohgi H., Kanisawa M., et al. Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice. Carcinogenesis 17 (1996) 767-770
78. Yamauchi H., Yamato N., and Yamamura Y. Metabolism and excretion of orally and intraperitoneally administered methylarsonic acid in the hamster. Bull Environ Contam Toxicol 40 (1988) 280-286
79. Zakharyan R.A., Wildfang E., and Aposhian H.V. Enzymatic methylation of arsenic compounds: III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic. Toxicol Appl Pharmacol 140 (1996) 77-84