Cellular pharmacology, antineoplastic activity and low in vivo toxicity of a carboxylato-bridged platinum(II) complex bis(acetato)diammine-bis-μ-acetato diplatinum (II) dihydrate

Medicinal Chemistry

Volumn 3, Issue 2, 2007, Pages 157-165

  Momekov, Georgi ^a   Konstantinov, Spiro ^a   Topashka Ancheva, Margarita ^b   Bakalova, Adriana ^a   Arpadjan, Sonja ^c   Karaivanova, Margarita ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b INSTITUTE OF BIODIVERSITY AND ECOSYSTEM RESEARCH   (Bulgaria)

^c UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Dinuclear platinum complexes; Genotoxicity; K 562; L 1210 leukemia; Lewis lung carcinoma; Nephrotoxicity

Indexed keywords

BIS(ACETATO)DIAMMINE BIS MU ACETATO DIPLATINUM DIHYDRATE; CISPLATIN; MITOMYCIN C; PLATINUM COMPLEX; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIS(ACETATO)DIAMMINE BIS MICRO ACETATO DIPLATINUM (II) DIHYDRATE; BIS(ACETATO)DIAMMINE-BIS-MICRO-ACETATO DIPLATINUM (II) DIHYDRATE; DNA; DNA FRAGMENT; MUTAGENIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW TOXICITY; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FEMALE; IN VIVO STUDY; LEUKEMIA; LEUKEMIA CELL; LEWIS CARCINOMA; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; BLOOD CELL COUNT; BONE MARROW CELL; C57BL MOUSE; CELL STRAIN K 562; CHEMICALLY INDUCED DISORDER; CHROMOSOME ABERRATION; DBA MOUSE; DRUG EFFECT; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; KIDNEY DISEASE; LEUKEMIA L 1210; PATHOLOGY; PHYSIOLOGY; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOOD CELL COUNT; BONE MARROW CELLS; CARCINOMA, LEWIS LUNG; CHROMOSOME ABERRATIONS; DNA FRAGMENTATION; DNA, NEOPLASM; HUMANS; K562 CELLS; KIDNEY DISEASES; LEUKEMIA L1210; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED ICR; MUTAGENS; ORGANOPLATINUM COMPOUNDS;

EID: 34248640565     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340607780059486     Document Type: Article

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