Effect of lactide/glycolide ratio on the in vitro release of ganciclovir and its lipophilic prodrug (GCV-monobutyrate) from PLGA microspheres

International Journal of Pharmaceutics

Volumn 338, Issue 1-2, 2007, Pages 133-141

  Janoria, Kumar G ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Controlled release; Cytomegalovirus retinitis; Drug prodrug; Ganciclovir; GCV monobutyrate; PLGA microspheres

Indexed keywords

BUTYRIC ACID; GANCICLOVIR; MICROSPHERE; POLYGLACTIN;

ARTICLE; DRUG RELEASE; EVAPORATION; GLASS TRANSITION TEMPERATURE; HYDROPHILICITY; IN VITRO STUDY; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; RETINITIS; SCANNING ELECTRON MICROSCOPY;

DELAYED-ACTION PREPARATIONS; GANCICLOVIR; LACTIC ACID; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; PRODRUGS; SOLUBILITY;

EID: 34248630510     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.01.038     Document Type: Article

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