The NOD allele of the Idd5 locus on chromosome 1 mediates a non-cell-autonomous defect in negative selection of T cells

Journal of Autoimmunity

Volumn 28, Issue 4, 2007, Pages 216-223

  Motta, Vinicius ^a   Lejon, Kristina ^a   Holmberg, Dan ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Autoimmunity; Diabetes; Superantigen; T cells

Indexed keywords

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHIMERA; CHROMOSOME 1; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE CONTROL; GENE LOCUS; GENETIC SUSCEPTIBILITY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ALLELES; ANIMALS; ANTIGENS, VIRAL; BONE MARROW; CHROMOSOMES; DIABETES MELLITUS, TYPE 1; MICE; MICE, INBRED NOD; QUANTITATIVE TRAIT LOCI; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPECIES SPECIFICITY; SUPERANTIGENS; T-LYMPHOCYTES; THYMUS GLAND; TRANSPLANTATION CHIMERA;

EID: 34248598664     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2007.03.001     Document Type: Article

References (36)

1. Makino S., Kunimoto K., Muraoka Y., Mizushima Y., Katagiri K., and Tochino Y. Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 29 (1980) 1-13
2. Wicker L.S., Todd J.A., and Peterson L.B. Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol 13 (1995) 179-200
3. Hattori M., Buse J.B., Jackson R.A., Glimcher L., Dorf M.E., Minami M., et al. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 231 (1986) 733-735
4. Prochazka M., Leiter E.H., Serreze D.V., and Coleman D.L. Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science 237 (1987) 286-289
5. Wicker L.S., Miller B.J., Coker L.Z., McNally S.E., Scott S., Mullen Y., et al. Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J Exp Med 165 (1987) 1639-1654
6. Carrasco-Marin E., Shimizu J., Kanagawa O., and Unanue E.R. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol 156 (1996) 450-458
7. Acha-Orbea H., and McDevitt H.O. The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc Natl Acad Sci U S A 84 (1987) 2435-2439
8. Tisch R., and McDevitt H. Insulin-dependent diabetes mellitus. Cell 85 (1996) 291-297
9. Todd J.A., Bell J.I., and McDevitt H.O. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329 (1987) 599-604
10. Ridgway W.M., and Fathman C.G. MHC structure and autoimmune T cell repertoire development. Curr Opin Immunol 11 (1999) 638-642
11. Shortman K., Egerton M., Spangrude G.J., and Scollay R. The generation and fate of thymocytes. Semin Immunol 2 (1990) 3-12
12. Surh C.D., and Sprent J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372 (1994) 100-103
13. Strasser A. Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms. Curr Opin Immunol 7 (1995) 228-234
14. Leijon K., Hammarstrom B., and Holmberg D. Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells. Int Immunol 6 (1994) 339-345
15. Kishimoto H., and Sprent J. A defect in central tolerance in NOD mice. Nat Immunol 2 (2001) 1025-1031
16. Garchon H.J., Luan J.J., Eloy L., Bedossa P., and Bach J.F. Genetic analysis of immune dysfunction in non-obese diabetic (NOD) mice: mapping of a susceptibility locus close to the Bcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction. Eur J Immunol 24 (1994) 380-384
17. Lamhamedi-Cherradi S.E., Luan J.J., Eloy L., Fluteau G., Bach J.F., and Garchon H.J. Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x. Diabetologia 41 (1998) 178-184
18. Bergman M.L., Duarte N., Campino S., Lundholm M., Motta V., Lejon K., et al. Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains. Diabetes 52 (2003) 1677-1682
19. Lesage S., Hartley S.B., Akkaraju S., Wilson J., Townsend M., and Goodnow C.C. Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J Exp Med 196 (2002) 1175-1188
20. Colucci F., Bergman M.L., Penha-Goncalves C., Cilio C.M., and Holmberg D. Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region. Proc Natl Acad Sci U S A 94 (1997) 8670-8674
21. Cilio C.M., Daws M.R., Malashicheva A., Sentman C.L., and Holmberg D. Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes. J Exp Med 188 (1998) 1239-1246
22. Buhlmann J.E., Elkin S.K., and Sharpe A.H. A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection. J Immunol 170 (2003) 5421-5428
23. Villunger A., Marsden V.S., and Strasser A. Efficient T cell receptor-mediated apoptosis in nonobese diabetic mouse thymocytes. Nat Immunol 4 (2003) 717-718 (author reply)
24. Soderstrom I., Bergman M.L., Colucci F., Lejon K., Bergqvist I., and Holmberg D. Establishment and characterization of RAG-2 deficient non-obese diabetic mice. Scand J Immunol 43 (1996) 525-530
25. Bill J., Kanagawa O., Woodland D.L., and Palmer E. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells. J Exp Med 169 (1989) 1405-1419
26. Hill N.J., Lyons P.A., Armitage N., Todd J.A., Wicker L.S., and Peterson L.B. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes 49 (2000) 1744-1747
27. Wicker L.S., Chamberlain G., Hunter K., Rainbow D., Howlett S., Tiffen P., et al. Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J Immunol 173 (2004) 164-173
28. Sheard M.A., Sharrow S.O., and Takahama Y. Synchronous deletion of Mtv-superantigen-reactive thymocytes in the CD3(medium/high) CD4(+)CD8(+) subset. Scand J Immunol 52 (2000) 550-554
29. Sprent J., and Kishimoto H. The thymus and negative selection. Immunol Rev 185 (2002) 126-135
30. Liston A., Lesage S., Gray D.H., O'Reilly L.A., Strasser A., Fahrer A.M., et al. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity 21 (2004) 817-830
31. Rojas M., Olivier M., Gros P., Barrera L.F., and Garcia L.F. TNF-alpha and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages. J Immunol 162 (1999) 6122-6131
32. Wojciechowski W., DeSanctis J., Skamene E., and Radzioch D. Attenuation of MHC class II expression in macrophages infected with Mycobacterium bovis bacillus Calmette-Guerin involves class II transactivator and depends on the Nramp1 gene. J Immunol 163 (1999) 2688-2696
33. Vidal S., Gros P., and Skamene E. Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus. J Leukoc Biol 58 (1995) 382-390
34. Kissler S., Stern P., Takahashi K., Hunter K., Peterson L.B., and Wicker L.S. In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat Genet 38 (2006) 479-483
35. Zucchelli S., Holler P., Yamagata T., Roy M., Benoist C., and Mathis D. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 22 (2005) 385-396
36. Williams J.A., Sharrow S.O., Adams A.J., and Hodes R.J. CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes. J Immunol 168 (2002) 2759-2765