Effects of adenoviral-mediated hepatocyte growth factor on liver regeneration after massive hepatectomy in rats

Acta Medica Okayama

Volumn 61, Issue 2, 2007, Pages 81-88

  Yuasa, Ichiro ^a   Tsukuda, Kazunori ^a   Hirai, Ryuji ^a   Ota, Tetsuya ^a   Murakami, Masakazu ^a   Naito, Minoru ^a   Doihara, Hiroyoshi ^a   Date, Hiroshi ^a   Shimizu, Nobuyoshi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Adenoviral vector; Gene therapy; Hepatectomy; HGF

Indexed keywords

ADENOVIRIDAE; RATTUS;

SCATTER FACTOR;

ADENOVIRUS; ANIMAL; APOPTOSIS; ARTICLE; BLOOD; CELL PROLIFERATION; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; LIVER; LIVER CELL; LIVER REGENERATION; LIVER RESECTION; METABOLISM; MORTALITY; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; TIME; UPREGULATION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL PROLIFERATION; GENETIC VECTORS; HEPATECTOMY; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; LIVER; LIVER REGENERATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 34248594562     PISSN: 0386300X     EISSN: 0386300X     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Chuang VP and Wallace S: Hepatic artery embolization in the treatment of hepatic neoplasms. Radiology (1981) 140: 51-58.
2. Fusai G and Davidson BR: Management of colorectal liver metastases. Colorectal Dis (2003) 5: 2-23.
3. Llovet JM, Burroughs A and Bruix J: Hepatocellular carcinoma. Lancet (2003) 362: 1907-1917.
4. Kountouras J, Boura P and Lygidakis NJ: Liver regeneration after hepatectomy. Hepatogastroenterology (2001) 48: 556-562.
5. Laurent S, Otsuka M, De Saeger C, Maiter D, Lambotte L and Horsmans Y: Expression of presumed specific early and late factors associated with liver regeneration in different rat surgical models. Lab Invest (2001) 81: 1299-1307.
6. Pediaditakis P, Lepez-Talavera JC, Petersen B, Monga SPS and Michalopoulos GK: The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat. Hepatology (2001) 34: 688-693.
7. Ishii T, Sato M, Sudo K, Suzuki M, Nakai H, Hishida T, Niwa T, Umezu K and Yuasa S: Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats. J Biochem (1995) 117: 1105-1112.
8. Yoshiwaka A, Kaido T, Seto S, Yamaoka S, Sato M, Ishii T and Imamura M: Hepatocyte growth factor promotes liver regeneration with prompt improvement of hyperbilirubinemia in hepatectomized cholestatic rats. J Surg Res (1998) 78: 54-59.
9. Eguchi S, Kamlot A, Ljubimova J, Hewitt WR, Lebow LT, Demetriou AA and Rozga J: Fulminant hepatic failure in rats: Survival and effect on blood chemistry and liver regeneration. Hepatology (1996) 24: 1452-1459.
10. Phaneuf D, Chen SJ and Wilson JM: Intravenous injection of an adenovirus encoding hepatocyte growth factor results in liver growth and has a protective effect against apoptosis. Mol Med (2000) 6: 96-103.
11. Nomi T, Shiota G, Isono M, Sato K and Kawasaki H: Adenovirus-mediated hepatocyte growth factor gene transfer prevents lethal liver failure in rats. Biochem Biophys Res Commun (2000) 278: 338-343.
12. Shiota G, Kunisada T, Oyama K, Udagawa A, Nomi T, Tanaka K, Tsutsumi A, Isono M, Nakamura T, Hamada H, Sakatani T, Sell S, Sato K, Ito H and Kawasaki H: In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/parital hepatectomy model in rats. FEBS Lett (2000) 470, 325-330.
13. Fujita J, Marino MW, Wada H, Jungbluth AA, Mackrell PJ, Rivadeneira DE, Stapleton PP and Daly JM: Effect of TNF gene depletion on liver regeneration after partial hepatectomy in mice. Surgery (2001) 126: 48-54.
14. Hwang TH, Yoon BC, Jeong JS, Seo SY and Lee HJ: A single administration of adenovial-mediated HGF cDNA permits survival of mice from acute hepatic failure. Life Sci (2003) 72: 851-861.
15. Takeuchi E, Nimura Y, Nagino M, Kurumiya Y, Maeda A, Kamiya J, Kondo S, Kanai M, Miyachi M, Uesaka K and Yoshida S: Human hepatocyte growth factor in bile: An indicator of posthepatectomy liver function in patients with biliary tract carcinoma. Hepatology (1997) 26: 1092-1099.
16. Hayata A, Takeuchi E, Nagino M, Yoshida S and Nimura Y: Hepatocyte growth factor concentration in rat bile is affected by hepatic resection volume and external biliary drainage. J Surg Res (1999) 85: 71-76.
17. Tomiya T, Ogata I, Yamaoka M, Yanase M, Inoue Y and Fujiwara K: The mitogenic activity of hepatocyte growth factor on rat hepatocytes in dependent upon endogenous transforming growth factor-alpha. Am J Pathol (2000) 157: 1693-1701.
18. Chijiiwa K, Saiki S and Tanaka M: Serum interleukin-6 and hepatocyte growth factor levels in patients after hepatectomy. Hepatogastroenterology (2002) 49: 467-471.
19. Galun E, Zeira E, Pappo O, Peters M and Rose-John S: Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury. FASEB J (2000) 14: 1979-1987.
20. Nunes FA, Furth EE, Wilson JM and Raper SE: Gene transfer into the liver of nonhuman primates with E1-deleted recombinant adenoviral vectors: safety of readministration. Hum Gene Ther (1999) 10: 2515-2526.
21. Schnell MA, Zhang Y, Tazelaar J, Gao GP, Yu QC, Qian R, Chen SJ, Varnavski AN, LeClair C, Raper SE and Wilson JM: Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther (2001) 3: 708-722.
22. Adachi K, Fujino M, Kitazawa Y, Funeshima N and Li SK: Genetic heterogeneity and efficiency of two different methods of adenovirus-mediated gene transfer in a rat liver transplantation model. Surg Today (2006) 36: 367-375.
23. Xue F, Takahara T, Yata Y, Kuwabara Y, Shinno E, Nonome K, Minemura M, Takahara S, Li X, Yamato E and Watanabe A: Hepatocyte growth factor gene therapy accelerates regeneration in cirrhotic mouse liver after hepatectomy. Gut (2003) 52: 694-700.
24. Kosai K, Matsumoto K, Funakoshi H and Nakamura T: Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology (1999) 30: 151-159.
25. Ozeki M, Ishii T, Hirano Y and Tabata Y: Controlled release of hepatocyte growth factor from gelatin hydrogels based on hydrogel degradation. J Drug Target (2001) 9: 461-471.
26. Palmer DJ and Ng P: Helper-dependent adenoviral vectors for gene therapy. Hum Gene Ther (2005) 16: 1-16.
27. Mian A, Guenther M, Finegold M, Ng P, Rodgers J and Lee B: Toxicity and adaptive immune response to intracellular transgenes delivered by helper-dependent vs. first generation adenoviral vectors. Mol Genet Metab (2005) 84: 278-288.
28. Han J, Tsukada Y, Hara E, Kitamura N and Tanaka T: Hepatocyte growth factor induces redistribution of p21 (CIP1) and p27 (KIP1) through ERK-dependent p16 (INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem (2005) 280: 31548-31556.
29. Yuge K, Takahashi T, Nagano S, Terazaki Y, Murofushi Y, Ushikoshi H, Kawai T, Khai NC, Nakamura T, Fujiwara H and Kosai K: Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma. Int J Oncol (2005) 27: 77-85.
30. Parr C and Jiang WG: Hepatocyte growth factor activators, inhibitors and antagonists and their implication in cancer intervention. Histol Histopathol (2001) 16: 251-268.
31. Guirouilh J, Castroviejo M, Balabaud C, Desmouliere A and Rosenbaum J: Hepatocarcinoma cells stimulate hepatocyte growth factor secretion in human liver myofibroblasts. Int J Oncol (2000) 17: 777-781.
32. Efimova EA, Glanemann M, Liu L, Schumacher G, Settmacher U, Jonas S, Langrehr JM, Neuhaus P and Nussler AK: Effects of human hepatocyte growth factor on the proliferation of human hepatocytes and hepatocellular carcinoma cell lines. Eur Surg Res (2004) 36: 300-307.